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Aliases for CMTM5 Gene

Aliases for CMTM5 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 5 2 3 5
  • Chemokine-Like Factor Superfamily Member 5 3 4
  • Chemokine-Like Factor Super Family 5 2 3
  • CKLFSF5 3 4
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 5 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 5 2
  • Chemokine-Like Factor Superfamily 5 2

External Ids for CMTM5 Gene

Previous HGNC Symbols for CMTM5 Gene


Previous GeneCards Identifiers for CMTM5 Gene

  • GC14P022916
  • GC14P023846
  • GC14P003962
  • GC14P023468
  • GC14P023549
  • GC14P023650
  • GC14P023683
  • GC14P023869
  • GC14P023929
  • GC14P024040
  • GC14P024155

Summaries for CMTM5 Gene

Entrez Gene Summary for CMTM5 Gene

  • This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CMTM5 Gene

CMTM5 (CKLF Like MARVEL Transmembrane Domain Containing 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM3.

Additional gene information for CMTM5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM5 Gene

Genomics for CMTM5 Gene

GeneHancer (GH) Regulatory Elements for CMTM5 Gene

Promoters and enhancers for CMTM5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J023376 Promoter/Enhancer 0.8 EPDnew ENCODE 650.7 0.0 -23 0.5 POLR2A CMTM5 IL25
GH14J023377 Enhancer 0.3 ENCODE 650.7 +0.7 712 0.2 NFE2L2 CMTM5 MYH6 SLC22A17 MIR208B PPP1R3E HOMEZ BCL2L2 MIR208A
GH14J023284 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 -91.1 -91057 3.4 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 HOMEZ PIR53909 ACIN1 PRMT5 IPO4 RNF31 NGDN THTPA TSSK4 RABGGTA
GH14J023056 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -319.2 -319211 3 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 SLC30A9 ZNF213 ZNF143 SP3 CDH24 LOC105370705 ACIN1 NGDN RBM23 PRMT5 C14orf93 MMP14 LOC102724814 HAUS4
GH14J023159 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.5 -214.3 -214349 5.2 HDGF PKNOX1 CLOCK ATF1 ARNT SIN3A TCF12 ZNF121 GATA2 ZNF143 CMTM5 ACIN1 RNF31 PSMB5 DHRS4L1 DHRS4L2 RNU6-1138P SLC7A8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CMTM5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CMTM5 gene promoter:
  • p53
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for CMTM5 Gene

Genomic Locations for CMTM5 Gene
2,965 bases
Plus strand
2,965 bases
Plus strand

Genomic View for CMTM5 Gene

Genes around CMTM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM5 Gene

Proteins for CMTM5 Gene

  • Protein details for CMTM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • E9PH91
    • Q5PY48

    Protein attributes for CMTM5 Gene

    223 amino acids
    Molecular mass:
    24653 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM5 Gene

neXtProt entry for CMTM5 Gene

Post-translational modifications for CMTM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CMTM5 Gene

Domains & Families for CMTM5 Gene

Gene Families for CMTM5 Gene

Protein Domains for CMTM5 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the chemokine-like factor family.
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM5: view

Function for CMTM5 Gene

Gene Ontology (GO) - Molecular Function for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CMTM5: view
genes like me logo Genes that share phenotypes with CMTM5: view

Animal Models for CMTM5 Gene

MGI Knock Outs for CMTM5:
  • Cmtm5 Cmtm5<tm1a(KOMP)Wtsi>

Animal Model Products

miRNA for CMTM5 Gene

miRTarBase miRNAs that target CMTM5

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CMTM5 Gene

Localization for CMTM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTM5 gene
Compartment Confidence
plasma membrane 3
extracellular 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with CMTM5: view

Pathways & Interactions for CMTM5 Gene

SuperPathways for CMTM5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0045662 negative regulation of myoblast differentiation IEA --
genes like me logo Genes that share ontologies with CMTM5: view

No data available for Pathways by source and SIGNOR curated interactions for CMTM5 Gene

Drugs & Compounds for CMTM5 Gene

No Compound Related Data Available

Transcripts for CMTM5 Gene

Unigene Clusters for CMTM5 Gene

CKLF-like MARVEL transmembrane domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: - - - -
SP3: -
SP4: - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for CMTM5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMTM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CMTM5 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x12.9) and Brain - Substantia nigra (x6.3).

Protein differential expression in normal tissues from HIPED for CMTM5 Gene

This gene is overexpressed in Platelet (40.1), Peripheral blood mononuclear cells (12.9), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CMTM5 Gene

Protein tissue co-expression partners for CMTM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of CMTM5 Gene:


SOURCE GeneReport for Unigene cluster for CMTM5 Gene:


mRNA Expression by UniProt/SwissProt for CMTM5 Gene:

Tissue specificity: Highly expressed in the brain.

Evidence on tissue expression from TISSUES for CMTM5 Gene

  • Nervous system(4.5)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with CMTM5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CMTM5 Gene

Orthologs for CMTM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CMTM5 34 33
  • 99.36 (n)
(Canis familiaris)
Mammalia CMTM5 34 33
  • 90.6 (n)
(Bos Taurus)
Mammalia CMTM5 34 33
  • 90.38 (n)
(Mus musculus)
Mammalia Cmtm5 16 34 33
  • 86.97 (n)
(Rattus norvegicus)
Mammalia Cmtm5 33
  • 86.75 (n)
(Monodelphis domestica)
Mammalia CMTM5 34
  • 46 (a)
(Gallus gallus)
Aves -- 34
  • 29 (a)
(Anolis carolinensis)
Reptilia CMTM5 34
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cmtm5 33
  • 58.52 (n)
(Danio rerio)
Actinopterygii zgc:136605 34
  • 22 (a)
Species where no ortholog for CMTM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM5 Gene

Gene Tree for CMTM5 (if available)
Gene Tree for CMTM5 (if available)
Evolutionary constrained regions (ECRs) for CMTM5: view image

Paralogs for CMTM5 Gene

Paralogs for CMTM5 Gene

(1) SIMAP similar genes for CMTM5 Gene using alignment to 3 proteins:

  • Q8N1V5_HUMAN
genes like me logo Genes that share paralogs with CMTM5: view

Variants for CMTM5 Gene

Sequence variations from dbSNP and Humsavar for CMTM5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000814044 -- 23,379,451(+) C/T intron_variant
rs1001043779 -- 23,377,505(+) C/T intron_variant
rs1001356831 -- 23,377,818(+) A/T intron_variant
rs1001547261 -- 23,374,989(+) G/T upstream_transcript_variant
rs1001601004 -- 23,380,236(+) C/T downstream_transcript_variant

Variation tolerance for CMTM5 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CMTM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CMTM5 Gene

Disorders for CMTM5 Gene

Additional Disease Information for CMTM5

No disorders were found for CMTM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM5 Gene

Publications for CMTM5 Gene

  1. [Abnormally lower expression of cmtm5 gene in bone marrow cells from patients with multiple myeloma]. (PMID: 20416169) Niu JH … Ruan GR (Zhongguo shi yan xue ye xue za zhi 2010) 3 22 58
  2. CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines. (PMID: 17908965) Shao L … Tao Q (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W … Ma D (Genomics 2003) 3 4 58
  5. Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function. (PMID: 28457985) Zhang JW … Liu ML (Gene 2017) 3 58

Products for CMTM5 Gene

Sources for CMTM5 Gene

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