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Aliases for CMTM4 Gene

Aliases for CMTM4 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 4 2 3 5
  • Chemokine-Like Factor Superfamily Member 4 3 4
  • Chemokine-Like Factor Super Family 4 2 3
  • CKLFSF4 3 4
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 4 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 4 2
  • Chemokine-Like Factor Superfamily 4 2

External Ids for CMTM4 Gene

Previous HGNC Symbols for CMTM4 Gene

  • CKLFSF4

Previous GeneCards Identifiers for CMTM4 Gene

  • GC16M065207
  • GC16M066648
  • GC16M052524
  • GC16M066616

Summaries for CMTM4 Gene

Entrez Gene Summary for CMTM4 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM4 Gene

CMTM4 (CKLF Like MARVEL Transmembrane Domain Containing 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM6.

UniProtKB/Swiss-Prot for CMTM4 Gene

  • Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.

Additional gene information for CMTM4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM4 Gene

Genomics for CMTM4 Gene

GeneHancer (GH) Regulatory Elements for CMTM4 Gene

Promoters and enhancers for CMTM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J066695 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 656 +0.3 306 2.5 SIN3A ZNF2 ZNF48 POLR2B GLIS2 ZNF213 ZNF143 KLF7 SP3 MXD4 CMTM4 GC16P066696 ACD CTCF BEAN1 CMTM3 NAE1 CA7 ENSG00000259804 GC16M066696
GH16J066659 Enhancer 1.2 Ensembl ENCODE 17 +35.3 35317 2.8 PKNOX1 SMAD1 ARNT ARID4B YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF766 CMTM4 BEAN1 DYNC1LI2 ENSG00000246777 CA7 CES2 TK2 GC16M066667 GC16P066646
GH16J066406 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +288.6 288637 4.1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 ARID2 LINC00920 CDH5 CMTM2 CMTM4 DYNC1LI2 ENSG00000246777 CA7 RRAD CMTM3 GC16M066396
GH16J066739 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.8 -44.7 -44722 3.9 RAD21 ZEB1 ZNF335 ZNF366 ZNF143 ATF7 ZNF654 ZNF362 RXRA CEBPB CMTM4 BEAN1 CA7 CES2 TERB1 ENSG00000260558 ENSG00000246777 DYNC1LI2
GH16J066650 Enhancer 1.1 Ensembl ENCODE 12.5 +45.6 45596 1.1 ARNT ARID4B FEZF1 ARID2 ZNF143 ATF7 RUNX3 KAT8 SSRP1 RFX3 BEAN1 CMTM4 DYNC1LI2 ENSG00000246777 TK2 CMTM3 GC16P066646 GC16M066667
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CMTM4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CMTM4 gene promoter:

Genomic Locations for CMTM4 Gene

Genomic Locations for CMTM4 Gene
chr16:66,598,214-66,696,707
(GRCh38/hg38)
Size:
98,494 bases
Orientation:
Minus strand
chr16:66,648,653-66,730,610
(GRCh37/hg19)

Genomic View for CMTM4 Gene

Genes around CMTM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM4 Gene

Proteins for CMTM4 Gene

  • Protein details for CMTM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZR5-CKLF4_HUMAN
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 4
    Protein Accession:
    Q8IZR5
    Secondary Accessions:
    • Q52M40
    • Q8IZR4
    • Q8IZV1

    Protein attributes for CMTM4 Gene

    Size:
    234 amino acids
    Molecular mass:
    25828 Da
    Quaternary structure:
    • Interacts with PD-L1/CD274 and CMTM6.

    Alternative splice isoforms for CMTM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMTM4 Gene

Post-translational modifications for CMTM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM4 Gene

No data available for DME Specific Peptides for CMTM4 Gene

Domains & Families for CMTM4 Gene

Gene Families for CMTM4 Gene

Protein Domains for CMTM4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CMTM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZR5

UniProtKB/Swiss-Prot:

CKLF4_HUMAN :
  • Belongs to the chemokine-like factor family.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM4: view

Function for CMTM4 Gene

Molecular function for CMTM4 Gene

UniProtKB/Swiss-Prot Function:
Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.

Phenotypes From GWAS Catalog for CMTM4 Gene

Gene Ontology (GO) - Molecular Function for CMTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 28813410
genes like me logo Genes that share ontologies with CMTM4: view
genes like me logo Genes that share phenotypes with CMTM4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CMTM4

miRNA for CMTM4 Gene

miRTarBase miRNAs that target CMTM4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM4 Gene

Localization for CMTM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTM4 gene
Compartment Confidence
plasma membrane 4
extracellular 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CMTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with CMTM4: view

Pathways & Interactions for CMTM4 Gene

SuperPathways for CMTM4 Gene

No Data Available

Interacting Proteins for CMTM4 Gene

Gene Ontology (GO) - Biological Process for CMTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with CMTM4: view

No data available for Pathways by source and SIGNOR curated interactions for CMTM4 Gene

Drugs & Compounds for CMTM4 Gene

No Compound Related Data Available

Transcripts for CMTM4 Gene

mRNA/cDNA for CMTM4 Gene

Unigene Clusters for CMTM4 Gene

CKLF-like MARVEL transmembrane domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for CMTM4 Gene

GeneLoc Exon Structure for
CMTM4
ECgene alternative splicing isoforms for
CMTM4

Expression for CMTM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CMTM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CMTM4 Gene

This gene is overexpressed in Spleen (22.5), Lung (17.4), and Retina (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CMTM4 Gene



Protein tissue co-expression partners for CMTM4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CMTM4 Gene:

CMTM4

SOURCE GeneReport for Unigene cluster for CMTM4 Gene:

Hs.643961

mRNA Expression by UniProt/SwissProt for CMTM4 Gene:

Q8IZR5-CKLF4_HUMAN
Tissue specificity: Highly expressed in testis and prostate.

Evidence on tissue expression from TISSUES for CMTM4 Gene

  • Kidney(4.3)
  • Liver(4.1)
  • Spleen(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with CMTM4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CMTM4 Gene

Orthologs for CMTM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMTM4 34 33
  • 99.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CMTM4 34 33
  • 94.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cmtm4 16 34 33
  • 92.31 (n)
rat
(Rattus norvegicus)
Mammalia Cmtm4 33
  • 91.83 (n)
oppossum
(Monodelphis domestica)
Mammalia CMTM4 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMTM4 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMTM4 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CMTM4 34 33
  • 80.68 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMTM4 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498042 33
  • 69.65 (n)
zebrafish
(Danio rerio)
Actinopterygii cmtm4 34 33
  • 67.97 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2454 34
  • 26 (a)
OneToMany
Species where no ortholog for CMTM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM4 Gene

ENSEMBL:
Gene Tree for CMTM4 (if available)
TreeFam:
Gene Tree for CMTM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CMTM4: view image

Paralogs for CMTM4 Gene

Paralogs for CMTM4 Gene

(2) SIMAP similar genes for CMTM4 Gene using alignment to 2 proteins:

  • CKLF4_HUMAN
  • J3QRP2_HUMAN
genes like me logo Genes that share paralogs with CMTM4: view

Variants for CMTM4 Gene

Sequence variations from dbSNP and Humsavar for CMTM4 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000003366 -- 66,681,778(-) T/A intron_variant
rs1000008426 -- 66,662,670(-) C/T intron_variant
rs1000038398 -- 66,669,814(-) G/A intron_variant
rs1000053829 -- 66,672,228(-) TCTCT/TCT intron_variant
rs1000063464 -- 66,660,832(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM4 Gene

Variant ID Type Subtype PubMed ID
nsv1071337 CNV deletion 25765185

Variation tolerance for CMTM4 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CMTM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMTM4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM4 Gene

Disorders for CMTM4 Gene

Additional Disease Information for CMTM4

No disorders were found for CMTM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM4 Gene

Publications for CMTM4 Gene

  1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W … Ma D (Genomics 2003) 2 3 4 58
  2. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. (PMID: 28813410) Mezzadra R … Schumacher TNM (Nature 2017) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CMTM4 Gene

Sources for CMTM4 Gene

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