This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008] See more...

Aliases for CMTM2 Gene

Aliases for CMTM2 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 2 2 3 5
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 2 3 4
  • Chemokine-Like Factor Superfamily Member 2 3 4
  • Chemokine-Like Factor Superfamily 2 2 3
  • CKLFSF2 3 4
  • CKLF-Like MARVEL Transmembrane Domain Containing 2 2
  • Chemokine-Like Factor Super Family 2 2
  • MGC39436 2
  • FLJ25732 2
  • CMTM2 5

External Ids for CMTM2 Gene

Previous HGNC Symbols for CMTM2 Gene

  • CKLFSF2

Previous GeneCards Identifiers for CMTM2 Gene

  • GC16P065172
  • GC16P066616
  • GC16P052489

Summaries for CMTM2 Gene

Entrez Gene Summary for CMTM2 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM2 Gene

CMTM2 (CKLF Like MARVEL Transmembrane Domain Containing 2) is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM1.

Gene Wiki entry for CMTM2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CMTM2 Gene

Genomics for CMTM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CMTM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J066578 Promoter/Enhancer 0.8 EPDnew Ensembl ENCODE 250.7 -0.1 -147 0.6 CMTM2 ENSG00000260650 TK2 piR-33614-103 CMTM1 CKLF-CMTM1
GH16J066580 Enhancer 0.7 ENCODE 250.7 +1.8 1849 2.2 ZNF600 ZNF10 CEBPB DEK EP300 RAD21 SMC3 CTCF INSM2 EGR1 CMTM2 ENSG00000260650 BEAN1 CMTM3 TK2 CKLF CKLF-CMTM1 HSALNG0112107
GH16J066547 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 -28.1 -28070 7.2 ZNF207 MYC ZNF600 IKZF1 ZNF580 ZNF592 ZMYM3 ATF2 KLF9 POLR2A TK2 CKLF CKLF-CMTM1 ENSG00000275745 lnc-CMTM4-1 piR-33426 piR-57466 NAE1 ZDHHC1 BEAN1
GH16J066406 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -171.4 -171361 4.1 ZNF654 ZNF600 JUND KLF9 CHD4 ZBTB10 YY1 MXD4 CEBPB CTCF LINC00920 HSALNG0112089 CDH5 CMTM2 CMTM4 DYNC1LI2 LOC106699570 CA7 RRAD CMTM3
GH16J066515 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -62.3 -62275 4.1 BCLAF1 SP1 NCOR1 MYC ZNF600 SSRP1 JUND ZNF592 ZMYM3 KLF9 BEAN1-AS1 ENSG00000260851 HSALNG0112101 ENSG00000260465 ZDHHC1 NAE1 BEAN1 TK2 CKLF CKLF-CMTM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CMTM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CMTM2

Top Transcription factor binding sites by QIAGEN in the CMTM2 gene promoter:
  • E47
  • Hand1
  • HOXA3
  • Lhx3a
  • LHX3b
  • Oct-B1
  • oct-B2
  • POU2F1
  • POU2F1a
  • POU3F1

Genomic Locations for CMTM2 Gene

Latest Assembly
chr16:66,579,448-66,588,275
(GRCh38/hg38)
Size:
8,828 bases
Orientation:
Plus strand

Previous Assembly
chr16:66,613,366-66,622,178
(GRCh37/hg19 by Entrez Gene)
Size:
8,813 bases
Orientation:
Plus strand

chr16:66,613,351-66,622,178
(GRCh37/hg19 by Ensembl)
Size:
8,828 bases
Orientation:
Plus strand

Genomic View for CMTM2 Gene

Genes around CMTM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM2 Gene

Proteins for CMTM2 Gene

  • Protein details for CMTM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAZ6-CKLF2_HUMAN
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 2
    Protein Accession:
    Q8TAZ6
    Secondary Accessions:
    • Q5I2A4
    • Q8N7E5

    Protein attributes for CMTM2 Gene

    Size:
    248 amino acids
    Molecular mass:
    27496 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMTM2 Gene

Post-translational modifications for CMTM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM2 Gene

No data available for DME Specific Peptides for CMTM2 Gene

Domains & Families for CMTM2 Gene

Gene Families for CMTM2 Gene

Protein Domains for CMTM2 Gene

InterPro:
Blocks:
  • Marvel

Suggested Antigen Peptide Sequences for CMTM2 Gene

GenScript: Design optimal peptide antigens:
  • Chemokine-like factor superfamily member 2 (CKLF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TAZ6

UniProtKB/Swiss-Prot:

CKLF2_HUMAN :
  • Belongs to the chemokine-like factor family.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM2: view

Function for CMTM2 Gene

Phenotypes From GWAS Catalog for CMTM2 Gene

Gene Ontology (GO) - Molecular Function for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with CMTM2: view
genes like me logo Genes that share phenotypes with CMTM2: view

miRNA for CMTM2 Gene

miRTarBase miRNAs that target CMTM2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CMTM2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM2 Gene

Localization for CMTM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM2 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTM2 gene
Compartment Confidence
nucleus 4
plasma membrane 3
extracellular 3
golgi apparatus 1
peroxisome 0
cytosol 0

Gene Ontology (GO) - Cellular Components for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with CMTM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CMTM2 Gene

Pathways & Interactions for CMTM2 Gene

PathCards logo

SuperPathways for CMTM2 Gene

genes like me logo Genes that share pathways with CMTM2: view

Pathways by source for CMTM2 Gene

1 BioSystems pathway for CMTM2 Gene

Gene Ontology (GO) - Biological Process for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with CMTM2: view

No data available for SIGNOR curated interactions for CMTM2 Gene

Drugs & Compounds for CMTM2 Gene

No Compound Related Data Available

Transcripts for CMTM2 Gene

mRNA/cDNA for CMTM2 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CMTM2

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for CMTM2 Gene

GeneLoc Exon Structure for
CMTM2

Expression for CMTM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CMTM2 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM2 Gene

This gene is overexpressed in Testis (x35.7) and Whole Blood (x14.9).

Protein differential expression in normal tissues from HIPED for CMTM2 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CMTM2 Gene



Protein tissue co-expression partners for CMTM2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CMTM2

SOURCE GeneReport for Unigene cluster for CMTM2 Gene:

Hs.195685

mRNA Expression by UniProt/SwissProt for CMTM2 Gene:

Q8TAZ6-CKLF2_HUMAN
Tissue specificity: Highly expressed in testis.

Evidence on tissue expression from TISSUES for CMTM2 Gene

  • Muscle(4.5)
  • Kidney(2.7)
  • Nervous system(2.7)
  • Lymph node(2.7)
  • Liver(2.6)
  • Adrenal gland(2.4)
  • Gall bladder(2.4)
  • Heart(2.4)
  • Intestine(2.4)
  • Lung(2.4)
  • Pancreas(2.4)
  • Spleen(2.4)
  • Stomach(2.4)
  • Thyroid gland(2.4)
genes like me logo Genes that share expression patterns with CMTM2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CMTM2 Gene

Orthologs for CMTM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CMTM2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CMTM2 29 30
  • 96.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CMTM2 29 30
  • 75.05 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC479694 29
  • 74.92 (n)
CMTM2 30
  • 55 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cmtm2b 29 16 30
  • 59.2 (n)
OneToMany
Cmtm2a 30
  • 47 (a)
OneToMany
Species where no ortholog for CMTM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CMTM2 Gene

ENSEMBL:
Gene Tree for CMTM2 (if available)
TreeFam:
Gene Tree for CMTM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CMTM2: view image
Alliance of Genome Resources:
Additional Orthologs for CMTM2

Paralogs for CMTM2 Gene

genes like me logo Genes that share paralogs with CMTM2: view

Variants for CMTM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CMTM2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs2290182 -- p.Ile122Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CMTM2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CMTM2 Gene

Variant ID Type Subtype PubMed ID
dgv123n111 CNV duplication 26073780

Variation tolerance for CMTM2 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CMTM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMTM2
Leiden Open Variation Database (LOVD)
CMTM2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM2 Gene

Disorders for CMTM2 Gene

Additional Disease Information for CMTM2

No disorders were found for CMTM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM2 Gene

Publications for CMTM2 Gene

  1. Expression and localization of CKLFSF2 in human spermatogenesis. (PMID: 17334588) Liu G … Guo YL (Asian journal of andrology 2007) 3 22
  2. CKLFSF2 is highly expressed in testis and can be secreted into the seminiferous tubules. (PMID: 15896670) Shi S … Ma D (The international journal of biochemistry & cell biology 2005) 3 4
  3. A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene. (PMID: 15778092) Xu M … Ma D (The international journal of biochemistry & cell biology 2005) 3 22
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for CMTM2 Gene

Sources for CMTM2 Gene