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Aliases for CMTM2 Gene

Aliases for CMTM2 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 2 2 3 5
  • Chemokine-Like Factor Superfamily Member 2 3 4
  • Chemokine-Like Factor Superfamily 2 2 3
  • CKLFSF2 3 4
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 2 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 2 2
  • Chemokine-Like Factor Super Family 2 2

External Ids for CMTM2 Gene

Previous HGNC Symbols for CMTM2 Gene

  • CKLFSF2

Previous GeneCards Identifiers for CMTM2 Gene

  • GC16P065172
  • GC16P052489

Summaries for CMTM2 Gene

Entrez Gene Summary for CMTM2 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM2 Gene

CMTM2 (CKLF Like MARVEL Transmembrane Domain Containing 2) is a Protein Coding gene. Diseases associated with CMTM2 include Pelvic Varices. Among its related pathways are Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include cytokine activity.

Gene Wiki entry for CMTM2 Gene

Additional gene information for CMTM2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM2 Gene

Genomics for CMTM2 Gene

GeneHancer (GH) Regulatory Elements for CMTM2 Gene

Promoters and enhancers for CMTM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J066578 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 650.7 -0.3 -268 0.8 POLR2A CMTM2 ENSG00000260650 TK2 CKLF CKLF-CMTM1 CMTM1
GH16J066580 Enhancer 0.9 Ensembl ENCODE 650.7 +1.8 1849 2.2 CTCF PKNOX1 INSM2 RAD21 HIC1 ZNF335 ZNF366 EGR1 SCRT2 ZSCAN5C CMTM2 ENSG00000260650 BEAN1 CMTM3 CKLF CKLF-CMTM1 TK2
GH16J066547 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.5 -28.4 -28397 6.6 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF416 ZNF143 SP3 NFYC TK2 CKLF CKLF-CMTM1 ENSG00000261519 ENSG00000275745 PIR54425 PIR51465 NAE1 ZDHHC1 BEAN1
GH16J066515 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -58.2 -58224 12.4 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 TK2 CKLF ENSG00000260465 ZDHHC1 NAE1 BEAN1 CKLF-CMTM1 E2F4 CMTM2 PLEKHG4
GH16J066406 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -171.4 -171378 4.1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 ARID2 LINC00920 CDH5 CMTM2 CMTM4 DYNC1LI2 ENSG00000246777 CA7 RRAD CMTM3 GC16M066396
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CMTM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CMTM2 gene promoter:
  • Hand1
  • E47
  • POU3F1
  • HOXA3
  • LHX3b
  • Lhx3a
  • POU2F1
  • POU2F1a
  • Oct-B1
  • oct-B2

Genomic Locations for CMTM2 Gene

Genomic Locations for CMTM2 Gene
chr16:66,579,448-66,588,275
(GRCh38/hg38)
Size:
8,828 bases
Orientation:
Plus strand
chr16:66,613,351-66,622,178
(GRCh37/hg19)
Size:
8,828 bases
Orientation:
Plus strand

Genomic View for CMTM2 Gene

Genes around CMTM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM2 Gene

Proteins for CMTM2 Gene

  • Protein details for CMTM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAZ6-CKLF2_HUMAN
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 2
    Protein Accession:
    Q8TAZ6
    Secondary Accessions:
    • Q5I2A4
    • Q8N7E5

    Protein attributes for CMTM2 Gene

    Size:
    248 amino acids
    Molecular mass:
    27496 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMTM2 Gene

Post-translational modifications for CMTM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM2 Gene

No data available for DME Specific Peptides for CMTM2 Gene

Domains & Families for CMTM2 Gene

Gene Families for CMTM2 Gene

Protein Domains for CMTM2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CMTM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAZ6

UniProtKB/Swiss-Prot:

CKLF2_HUMAN :
  • Belongs to the chemokine-like factor family.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM2: view

Function for CMTM2 Gene

Phenotypes From GWAS Catalog for CMTM2 Gene

Gene Ontology (GO) - Molecular Function for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with CMTM2: view
genes like me logo Genes that share phenotypes with CMTM2: view

Animal Model Products

miRNA for CMTM2 Gene

miRTarBase miRNAs that target CMTM2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM2 Gene

Localization for CMTM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTM2 gene
Compartment Confidence
nucleus 4
plasma membrane 3
extracellular 3
golgi apparatus 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with CMTM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CMTM2 Gene

Pathways & Interactions for CMTM2 Gene

genes like me logo Genes that share pathways with CMTM2: view

Pathways by source for CMTM2 Gene

1 BioSystems pathway for CMTM2 Gene

Interacting Proteins for CMTM2 Gene

Gene Ontology (GO) - Biological Process for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with CMTM2: view

No data available for SIGNOR curated interactions for CMTM2 Gene

Drugs & Compounds for CMTM2 Gene

No Compound Related Data Available

Transcripts for CMTM2 Gene

mRNA/cDNA for CMTM2 Gene

Unigene Clusters for CMTM2 Gene

CKLF-like MARVEL transmembrane domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for CMTM2 Gene

GeneLoc Exon Structure for
CMTM2
ECgene alternative splicing isoforms for
CMTM2

Expression for CMTM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CMTM2 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM2 Gene

This gene is overexpressed in Testis (x35.7) and Whole Blood (x14.9).

Protein differential expression in normal tissues from HIPED for CMTM2 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CMTM2 Gene



Protein tissue co-expression partners for CMTM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CMTM2 Gene:

CMTM2

SOURCE GeneReport for Unigene cluster for CMTM2 Gene:

Hs.195685

mRNA Expression by UniProt/SwissProt for CMTM2 Gene:

Q8TAZ6-CKLF2_HUMAN
Tissue specificity: Highly expressed in testis.

Evidence on tissue expression from TISSUES for CMTM2 Gene

  • Muscle(4.5)
  • Adrenal gland(2.4)
  • Gall bladder(2.4)
  • Heart(2.4)
  • Intestine(2.4)
  • Kidney(2.4)
  • Liver(2.4)
  • Lung(2.4)
  • Lymph node(2.4)
  • Pancreas(2.4)
  • Spleen(2.4)
  • Stomach(2.4)
  • Thyroid gland(2.4)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with CMTM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CMTM2 Gene

Orthologs for CMTM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CMTM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMTM2 34 33
  • 96.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CMTM2 34 33
  • 75.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC479694 33
  • 74.92 (n)
CMTM2 34
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmtm2b 16 34 33
  • 59.2 (n)
Cmtm2a 34
  • 47 (a)
OneToMany
Species where no ortholog for CMTM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CMTM2 Gene

ENSEMBL:
Gene Tree for CMTM2 (if available)
TreeFam:
Gene Tree for CMTM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CMTM2: view image

Paralogs for CMTM2 Gene

No data available for Paralogs for CMTM2 Gene

Variants for CMTM2 Gene

Sequence variations from dbSNP and Humsavar for CMTM2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000101533 -- 66,588,766(+) C/T downstream_transcript_variant
rs1000987075 -- 66,587,243(+) G/A intron_variant
rs1001062668 -- 66,583,811(+) C/A intron_variant
rs1001536600 -- 66,587,472(+) G/A intron_variant
rs1001661934 -- 66,588,424(+) G/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM2 Gene

Variant ID Type Subtype PubMed ID
dgv123n111 CNV duplication 26073780

Variation tolerance for CMTM2 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CMTM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMTM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM2 Gene

Disorders for CMTM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CMTM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pelvic varices
- elite association - COSMIC cancer census association via MalaCards
Search CMTM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CMTM2

genes like me logo Genes that share disorders with CMTM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CMTM2 Gene

Publications for CMTM2 Gene

  1. Expression and localization of CKLFSF2 in human spermatogenesis. (PMID: 17334588) Liu G … Guo YL (Asian journal of andrology 2007) 3 22 58
  2. A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene. (PMID: 15778092) Xu M … Ma D (The international journal of biochemistry & cell biology 2005) 3 22 58
  3. CKLFSF2 is highly expressed in testis and can be secreted into the seminiferous tubules. (PMID: 15896670) Shi S … Ma D (The international journal of biochemistry & cell biology 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CMTM2 Gene

Sources for CMTM2 Gene

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