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Aliases for CMKLR1 Gene

Aliases for CMKLR1 Gene

  • Chemerin Chemokine-Like Receptor 1 2 3 5
  • G-Protein Coupled Receptor ChemR23 3 4
  • G-Protein Coupled Receptor DEZ 3 4
  • Chemokine-Like Receptor 1 2 3
  • Resolvin E1 Receptor 2 3
  • Chemerin Receptor 2 3
  • ChemR23 3 4
  • DEZ 3 4
  • Orphan G-Protein Coupled Receptor, Dez 3
  • Chemokine Receptor-Like 1 3
  • CHEMERINR 3
  • RVER1 3

External Ids for CMKLR1 Gene

Previous GeneCards Identifiers for CMKLR1 Gene

  • GC12M107791
  • GC12M108566
  • GC12M107187
  • GC12M108681
  • GC12M105746

Summaries for CMKLR1 Gene

GeneCards Summary for CMKLR1 Gene

CMKLR1 (Chemerin Chemokine-Like Receptor 1) is a Protein Coding gene. Diseases associated with CMKLR1 include Gerstmann Syndrome and Cataract 18. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is GPR1.

UniProtKB/Swiss-Prot for CMKLR1 Gene

  • Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Gene Wiki entry for CMKLR1 Gene

Additional gene information for CMKLR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMKLR1 Gene

Genomics for CMKLR1 Gene

GeneHancer (GH) Regulatory Elements for CMKLR1 Gene

Promoters and enhancers for CMKLR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I108336 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 676 4 PKNOX1 ATF1 ARNT NCOA2 TCF12 GATA2 ZNF143 ATF7 RUNX3 JUNB CMKLR1 GC12M108318
GH12I108320 Promoter/Enhancer 1.2 EPDnew Ensembl 550.4 +18.8 18784 0.7 HDGF SMAD5 BACH1 KLF5 ZFHX2 FOXK2 POLR2A TARDBP IKZF1 SCRT2 CMKLR1 ALKBH2 GC12M108318 GC12M108289
GH12I108301 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 17 +33.7 33715 7.7 ELF3 RAD21 EGR1 RCOR1 FOS RUNX3 EGR2 ELF1 NR2F2 ZNF217 CMKLR1 SART3 LINC01498 FICD ENSG00000257398 BTBD11 UNG CORO1C SELPLG GC12M108289
GH12I108311 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.9 +24.6 24599 6.5 HDGF ATF1 FOXA2 MLX ARID4B ZNF48 TCF12 GATA2 ZNF143 ATF7 CMKLR1 ALKBH2 GC12M108318 GC12M108289
GH12I108297 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.9 +40.7 40695 2.1 BCOR ZMYM3 EBF1 NFXL1 BATF IRF4 BRD9 RCOR1 ETV6 IKZF2 CMKLR1 GC12M108289 GC12M108318
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CMKLR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CMKLR1 gene promoter:

Genomic Locations for CMKLR1 Gene

Genomic Locations for CMKLR1 Gene
chr12:108,288,044-108,339,341
(GRCh38/hg38)
Size:
51,298 bases
Orientation:
Minus strand
chr12:108,681,821-108,733,118
(GRCh37/hg19)

Genomic View for CMKLR1 Gene

Genes around CMKLR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMKLR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMKLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMKLR1 Gene

Proteins for CMKLR1 Gene

  • Protein details for CMKLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99788-CML1_HUMAN
    Recommended name:
    Chemokine-like receptor 1
    Protein Accession:
    Q99788
    Secondary Accessions:
    • A8K6Y5
    • O75748
    • Q3KP37
    • Q5U0H0
    • Q99789

    Protein attributes for CMKLR1 Gene

    Size:
    373 amino acids
    Molecular mass:
    42322 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMKLR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMKLR1 Gene

Post-translational modifications for CMKLR1 Gene

  • Glycosylation at posLast=99 and Asn192

No data available for DME Specific Peptides for CMKLR1 Gene

Domains & Families for CMKLR1 Gene

Gene Families for CMKLR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for CMKLR1 Gene

Suggested Antigen Peptide Sequences for CMKLR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99788

UniProtKB/Swiss-Prot:

CML1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CMKLR1: view

Function for CMKLR1 Gene

Molecular function for CMKLR1 Gene

GENATLAS Biochemistry:
chemokine (C-C) like receptor 1
UniProtKB/Swiss-Prot Function:
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
UniProtKB/Swiss-Prot Induction:
Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells.

Phenotypes From GWAS Catalog for CMKLR1 Gene

Gene Ontology (GO) - Molecular Function for CMKLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004872 receptor activity TAS 9144535
GO:0004930 G-protein coupled receptor activity NAS 9603476
GO:0004950 chemokine receptor activity TAS 9425281
GO:0005515 protein binding IPI 14530373
genes like me logo Genes that share ontologies with CMKLR1: view
genes like me logo Genes that share phenotypes with CMKLR1: view

Animal Models for CMKLR1 Gene

MGI Knock Outs for CMKLR1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CMKLR1 Gene

Localization for CMKLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMKLR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMKLR1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CMKLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9425281
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9603476
genes like me logo Genes that share ontologies with CMKLR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CMKLR1 Gene

Pathways & Interactions for CMKLR1 Gene

genes like me logo Genes that share pathways with CMKLR1: view

Pathways by source for CMKLR1 Gene

1 BioSystems pathway for CMKLR1 Gene

Interacting Proteins for CMKLR1 Gene

Gene Ontology (GO) - Biological Process for CMKLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 9144535
GO:0006935 chemotaxis TAS,IDA 14530373
GO:0006955 immune response TAS 9425281
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,NAS 9603476
genes like me logo Genes that share ontologies with CMKLR1: view

No data available for SIGNOR curated interactions for CMKLR1 Gene

Drugs & Compounds for CMKLR1 Gene

(5) Drugs for CMKLR1 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Resolvin E1 Investigational Pharma Full agonist, Agonist 0
[<sup>3</sup>H]resolvin E1 Pharma Agonist 0
chemerin Pharma Full agonist, Agonist 0
chemerin C-terminal peptide Pharma Agonist 0
CCX832 Pharma 0
genes like me logo Genes that share compounds with CMKLR1: view

Transcripts for CMKLR1 Gene

mRNA/cDNA for CMKLR1 Gene

Unigene Clusters for CMKLR1 Gene

Chemokine-like receptor 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMKLR1 Gene

No ASD Table

Relevant External Links for CMKLR1 Gene

GeneLoc Exon Structure for
CMKLR1
ECgene alternative splicing isoforms for
CMKLR1

Expression for CMKLR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CMKLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CMKLR1 Gene

This gene is overexpressed in Spleen (x5.8), Artery - Aorta (x5.2), and Artery - Coronary (x4.4).

Protein differential expression in normal tissues from HIPED for CMKLR1 Gene

This gene is overexpressed in NK cells (42.0) and Placenta (27.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CMKLR1 Gene



Protein tissue co-expression partners for CMKLR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CMKLR1 Gene:

CMKLR1

SOURCE GeneReport for Unigene cluster for CMKLR1 Gene:

Hs.197143

mRNA Expression by UniProt/SwissProt for CMKLR1 Gene:

Q99788-CML1_HUMAN
Tissue specificity: Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.

Evidence on tissue expression from TISSUES for CMKLR1 Gene

  • Kidney(4.1)
  • Spleen(2.9)
  • Lymph node(2.5)
genes like me logo Genes that share expression patterns with CMKLR1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CMKLR1 Gene

Orthologs for CMKLR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMKLR1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CMKLR1 33 34
  • 87.4 (n)
cow
(Bos Taurus)
Mammalia CMKLR1 33
  • 85.82 (n)
CMLKR1 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmklr1 33
  • 82.66 (n)
mouse
(Mus musculus)
Mammalia Cmklr1 33 16 34
  • 82.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CMKLR1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC425507 33
  • 66.38 (n)
lizard
(Anolis carolinensis)
Reptilia CMKLR1 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cmklr1 33
  • 59.06 (n)
zebrafish
(Danio rerio)
Actinopterygii cmklr1 34
  • 39 (a)
OneToMany
CMKLR1 (2 of 3) 34
  • 36 (a)
OneToMany
CMKLR1 (3 of 3) 34
  • 36 (a)
OneToMany
Species where no ortholog for CMKLR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMKLR1 Gene

ENSEMBL:
Gene Tree for CMKLR1 (if available)
TreeFam:
Gene Tree for CMKLR1 (if available)

Paralogs for CMKLR1 Gene

Variants for CMKLR1 Gene

Sequence variations from dbSNP and Humsavar for CMKLR1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000215717 -- 108,339,389(-) C/T upstream_transcript_variant
rs1000230017 -- 108,310,535(-) C/G intron_variant
rs1000232274 -- 108,322,891(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000266238 -- 108,340,510(-) AAGAAAGAAAG/AAGAAAG upstream_transcript_variant
rs1000304925 -- 108,334,960(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CMKLR1 Gene

Variant ID Type Subtype PubMed ID
esv3580462 CNV loss 25503493

Variation tolerance for CMKLR1 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 39.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CMKLR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMKLR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMKLR1 Gene

Disorders for CMKLR1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CMKLR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gerstmann syndrome
  • aphasia-angular gyrus syndrome
cataract 18
  • ctrct18
enterocele
  • vaginal enterocele
prolapse of female genital organ
ideomotor apraxia
  • classic apraxia [ambiguous]
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CMKLR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CMKLR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CMKLR1 Gene

Publications for CMKLR1 Gene

  1. Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. (PMID: 20044979) Kaur J … Randeva HS (Biochemical and biophysical research communications 2010) 3 4 22 58
  2. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. (PMID: 9603476) Samson M … Parmentier M (European journal of immunology 1998) 3 4 22 58
  3. Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors. (PMID: 8976386) Gantz I … Yamada T (Cytogenetics and cell genetics 1996) 3 4 22 58
  4. Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy. (PMID: 21483023) Wu X … Yang P (Journal of the National Cancer Institute 2011) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CMKLR1 Gene

Sources for CMKLR1 Gene

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