Aliases for CMKLR1 Gene
External Ids for CMKLR1 Gene
Previous GeneCards Identifiers for CMKLR1 Gene
GeneCards Summary for CMKLR1 Gene
CMKLR1 (Chemerin Chemokine-Like Receptor 1) is a Protein Coding gene. Diseases associated with CMKLR1 include Monckeberg Arteriosclerosis and Cardiovascular Syphilis. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and chemokine receptor activity. An important paralog of this gene is C3AR1.
UniProtKB/Swiss-Prot Summary for CMKLR1 Gene
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).