This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] See more...

Aliases for CMIP Gene

Aliases for CMIP Gene

  • C-Maf Inducing Protein 2 3 5
  • C-Maf-Inducing Protein 3 4
  • Tc-Mip 3 4
  • TCMIP 3 4
  • Truncated C-Maf-Inducing Protein 4
  • KIAA1694 4
  • C-Mip 4
  • CMIP 5

External Ids for CMIP Gene

Previous GeneCards Identifiers for CMIP Gene

  • GC16P081258
  • GC16P080036
  • GC16P081478
  • GC16P067234

Summaries for CMIP Gene

Entrez Gene Summary for CMIP Gene

  • This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CMIP Gene

CMIP (C-Maf Inducing Protein) is a Protein Coding gene. Diseases associated with CMIP include Speech And Communication Disorders and Gastric Tubular Adenocarcinoma.

UniProtKB/Swiss-Prot Summary for CMIP Gene

  • Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CMIP Gene

Genomics for CMIP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CMIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J081442 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 254.9 +3.5 3466 11.6 TBP ZBTB10 MXD4 CEBPA MNT IKZF1 BRCA1 SMAD5 HES1 MBD2 CMIP HSALNG0112992 PLCG2 HSALNG0112991
GH16J081491 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 262.8 +48.9 48930 5.1 MXD4 MNT IKZF1 SMAD5 IRF2 HES1 MBD2 BHLHE40 ZEB1 NONO CMIP PPIAP51 HSALNG0112994 PLCG2
GH16J081608 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 250.1 +166.1 166123 5.7 RBM22 JUND SPI1 MAFK REST ZBTB33 ZNF664 NR2F1 RAD21 ATF2 MIR6504 CMIP MIR7854 PLCG2
GH16J081644 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 250.1 +201.7 201652 4.1 IKZF1 ZIC2 POLR2A RBM22 JUND FOSL1 YBX1 SCRT1 ZNF664 GLIS1 HSALNG0113002 CMIP HSALNG0113000 PLCG2
GH16J081476 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.7 +35.5 35540 7 CHD2 SP1 BCL11A CEBPA NR2C1 IKZF1 MBD2 ZNF217 POLR2A BHLHE40 CMIP PLCG2 PPIAP51 HSALNG0112994
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CMIP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CMIP

Top Transcription factor binding sites by QIAGEN in the CMIP gene promoter:
  • AML1a
  • ATF
  • NF-1
  • Pax-4a
  • PPAR-alpha
  • STAT1
  • STAT1alpha
  • STAT1beta
  • ZIC2

Genomic Locations for CMIP Gene

Latest Assembly
chr16:81,444,808-81,711,762
(GRCh38/hg38)
Size:
266,955 bases
Orientation:
Plus strand

Previous Assembly
chr16:81,478,413-81,745,367
(GRCh37/hg19 by Entrez Gene)
Size:
266,955 bases
Orientation:
Plus strand

chr16:81,478,775-81,745,367
(GRCh37/hg19 by Ensembl)
Size:
266,593 bases
Orientation:
Plus strand

Genomic View for CMIP Gene

Genes around CMIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMIP Gene

Proteins for CMIP Gene

  • Protein details for CMIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY22-CMIP_HUMAN
    Recommended name:
    C-Maf-inducing protein
    Protein Accession:
    Q8IY22
    Secondary Accessions:
    • Q9C0G9

    Protein attributes for CMIP Gene

    Size:
    773 amino acids
    Molecular mass:
    86331 Da
    Quaternary structure:
    • Interacts with FLNA.

    Alternative splice isoforms for CMIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMIP Gene

Post-translational modifications for CMIP Gene

  • Ubiquitination at Lys74 and Lys79
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CMIP Gene

Domains & Families for CMIP Gene

Gene Families for CMIP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CMIP Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for CMIP Gene

GenScript: Design optimal peptide antigens:
  • Truncated c-Maf-inducing protein (CMIP_HUMAN)
genes like me logo Genes that share domains with CMIP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CMIP Gene

Function for CMIP Gene

Molecular function for CMIP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.

Phenotypes From GWAS Catalog for CMIP Gene

Gene Ontology (GO) - Molecular Function for CMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20018188
genes like me logo Genes that share ontologies with CMIP: view
genes like me logo Genes that share phenotypes with CMIP: view

Animal Models for CMIP Gene

MGI Knock Outs for CMIP:
  • Cmip Cmip<tm1a(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CMIP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CMIP Gene

Localization for CMIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMIP Gene

Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343). {ECO:0000269 PubMed:12939343, ECO:0000269 PubMed:15616553}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMIP gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CMIP: view

Pathways & Interactions for CMIP Gene

PathCards logo

SuperPathways for CMIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with CMIP: view

No data available for Pathways by source and SIGNOR curated interactions for CMIP Gene

Drugs & Compounds for CMIP Gene

No Compound Related Data Available

Transcripts for CMIP Gene

mRNA/cDNA for CMIP Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CMIP

Alternative Splicing Database (ASD) splice patterns (SP) for CMIP Gene

No ASD Table

Relevant External Links for CMIP Gene

GeneLoc Exon Structure for
CMIP

Expression for CMIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CMIP Gene

Protein differential expression in normal tissues from HIPED for CMIP Gene

This gene is overexpressed in Platelet (28.0) and Peripheral blood mononuclear cells (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CMIP Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CMIP

SOURCE GeneReport for Unigene cluster for CMIP Gene:

Hs.594095

mRNA Expression by UniProt/SwissProt for CMIP Gene:

Q8IY22-CMIP_HUMAN
Tissue specificity: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.

Evidence on tissue expression from TISSUES for CMIP Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Lung(2.8)
  • Skin(2.5)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with CMIP: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CMIP Gene

Orthologs for CMIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMIP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CMIP 30 31
  • 99.65 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CMIP 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CMIP 30 31
  • 94.23 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CMIP 30 31
  • 94.21 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CMIP 31
  • 93 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cmip 30
  • 91.23 (n)
Mouse
(Mus musculus)
Mammalia Cmip 30 17 31
  • 91.11 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CMIP 30 31
  • 81.94 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CMIP 31
  • 94 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cmip 30
  • 79.66 (n)
Str.7218 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7889 30
Zebrafish
(Danio rerio)
Actinopterygii cmip 30 31
  • 78.72 (n)
OneToOne
Dr.27534 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToOne
Species where no ortholog for CMIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CMIP Gene

ENSEMBL:
Gene Tree for CMIP (if available)
TreeFam:
Gene Tree for CMIP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CMIP: view image

Paralogs for CMIP Gene

No data available for Paralogs for CMIP Gene

Variants for CMIP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CMIP Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
931712 Uncertain Significance: See cases 81,678,274(+) G/A
NM_198390.2(CMIP):c.1035-1G>A
SPLICE_ACCEPTOR
rs114894868 Benign: not provided 81,607,621(+) C/T
NM_198390.2(CMIP):c.355C>T (p.Leu119=)
SYNONYMOUS
rs1373813031 Likely Benign: not provided 81,445,331(+) C/G
NM_198390.2(CMIP):c.90C>G (p.Pro30=)
SYNONYMOUS
rs1597199609 Likely Benign: not provided 81,652,278(+) C/T
NM_198390.2(CMIP):c.553C>T (p.Leu185=)
SYNONYMOUS
rs1597214739 Likely Benign: not provided 81,664,259(+) C/T
NM_198390.2(CMIP):c.745-10C>T
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CMIP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CMIP Gene

Variant ID Type Subtype PubMed ID
dgv1645e59 CNV duplication 20981092
dgv373e201 CNV deletion 23290073
dgv374e201 CNV deletion 23290073
dgv5250n54 CNV loss 21841781
esv1774977 CNV deletion 17803354
esv2325065 CNV deletion 18987734
esv23710 CNV loss 19812545
esv2714779 CNV deletion 23290073
esv2714780 CNV deletion 23290073
esv2714781 CNV deletion 23290073
esv2714782 CNV deletion 23290073
esv2714783 CNV deletion 23290073
esv2714786 CNV deletion 23290073
esv2714789 CNV deletion 23290073
esv3256 CNV loss 18987735
esv34108 CNV loss 18971310
esv3419798 CNV duplication 20981092
esv3422126 CNV insertion 20981092
esv3553753 CNV deletion 23714750
esv3639330 CNV loss 21293372
esv3639334 CNV loss 21293372
esv3639335 CNV loss 21293372
esv3639337 CNV loss 21293372
esv3639338 CNV loss 21293372
esv3639339 CNV loss 21293372
nsv1070776 CNV deletion 25765185
nsv1071340 CNV deletion 25765185
nsv1076437 CNV duplication 25765185
nsv1118357 CNV deletion 24896259
nsv1118358 CNV deletion 24896259
nsv1126436 CNV deletion 24896259
nsv1132439 CNV duplication 24896259
nsv1134570 CNV deletion 24896259
nsv1136219 CNV deletion 24896259
nsv1138471 CNV deletion 24896259
nsv1898 CNV deletion 18451855
nsv457576 CNV loss 19166990
nsv510427 OTHER sequence alteration 20534489
nsv513456 CNV insertion 21212237
nsv518910 CNV loss 19592680
nsv520382 CNV loss 19592680
nsv521875 CNV loss 19592680
nsv522140 CNV gain 19592680
nsv524589 CNV loss 19592680
nsv526331 CNV loss 19592680
nsv573359 CNV loss 21841781
nsv573360 CNV loss 21841781
nsv952057 CNV deletion 24416366
nsv952058 CNV deletion 24416366
nsv978171 CNV duplication 23825009

Variation tolerance for CMIP Gene

Residual Variation Intolerance Score: 5.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CMIP Gene

Human Gene Mutation Database (HGMD)
CMIP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMIP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMIP Gene

Disorders for CMIP Gene

MalaCards: The human disease database

(18) MalaCards diseases for CMIP Gene - From: COP and GCD

Disorder Aliases PubMed IDs
speech and communication disorders
  • communication disorder
gastric tubular adenocarcinoma
  • tubular adenocarcinoma of stomach
lymphoepithelioma-like thymic carcinoma
  • lymphoepithelioma-like carcinoma of the thymus
reading disorder
  • reading
specific language impairment
  • language impairment, specific
- elite association - COSMIC cancer census association via MalaCards
Search CMIP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CMIP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CMIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CMIP Gene

Publications for CMIP Gene

  1. Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization. (PMID: 12939343) Grimbert P … Sahali D (The Journal of experimental medicine 2003) 2 3 4 23
  2. The Filamin-A is a partner of Tc-mip, a new adapter protein involved in c-maf-dependent Th2 signaling pathway. (PMID: 15128042) Grimbert P … Sahali D (Molecular immunology 2004) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  4. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z … Kathiresan S (PLoS genetics 2012) 3 41
  5. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 41

Products for CMIP Gene

Sources for CMIP Gene