Aliases for CMBL Gene
External Ids for CMBL Gene
Previous GeneCards Identifiers for CMBL Gene
CMBL (EC 220.127.116.11) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]
GeneCards Summary for CMBL Gene
CMBL (Carboxymethylenebutenolidase Homolog) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include hydrolase activity.
UniProtKB/Swiss-Prot for CMBL Gene
Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.