Aliases for CMBL Gene
External Ids for CMBL Gene
Previous GeneCards Identifiers for CMBL Gene
CMBL (EC 22.214.171.124) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]
GeneCards Summary for CMBL Gene
CMBL (Carboxymethylenebutenolidase Homolog) is a Protein Coding gene. Diseases associated with CMBL include Waardenburg Syndrome, Type 3 and Waardenburg Syndrome, Type 1. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity.
UniProtKB/Swiss-Prot Summary for CMBL Gene
Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.