Aliases for CLUL1 Gene

Aliases for CLUL1 Gene

  • Clusterin Like 1 2 3 5
  • Retinal-Specific Clusterin-Like Protein 3 4
  • Retinal Clusterin-Like Protein 2 3
  • Clusterin-Like 1 (Retinal) 2 3
  • Clusterin-Like Protein 1 3 4
  • RA337M 3

External Ids for CLUL1 Gene

Previous GeneCards Identifiers for CLUL1 Gene

  • GC18P000880
  • GC18P000584
  • GC18P000586

Summaries for CLUL1 Gene

GeneCards Summary for CLUL1 Gene

CLUL1 (Clusterin Like 1) is a Protein Coding gene. Diseases associated with CLUL1 include Myopia. An important paralog of this gene is CLU.

Additional gene information for CLUL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLUL1 Gene

Genomics for CLUL1 Gene

GeneHancer (GH) Regulatory Elements for CLUL1 Gene

Promoters and enhancers for CLUL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J000596 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 529.4 -0.1 -100 1.4 CTCF NRF1 TARDBP REST MYC CTBP1 SKI SMC3 HDAC2 ZNF341 CLUL1 THOC1 RN7SKP146 lnc-ENOSF1-6
GH18J000616 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 500.4 +18.5 18458 2.9 CTCF REST TOE1 RAD21 TRIM22 ATF2 SMC3 HDAC3 FOXA2 ZNF316 CLUL1 CETN1 COLEC12 THOC1 RF01016-006 LOC105371952
GH18J000597 Promoter/Enhancer 1 EPDnew ENCODE 512.1 +1.2 1186 0.9 ZBTB17 ZNF335 IKZF3 ZNF189 ZNF843 PRDM6 ZNF664 FEZF1 CEBPB PRDM4 CLUL1 THOC1 RF01016-006
GH18J000679 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11 +87.6 87605 10.4 TEAD4 ZIC2 TBX3 HDAC2 POLR2A FOXA2 NFIC PBX2 POLR2G NANOG lnc-YES1-1 piR-50437-288 ENOSF1 TYMS TYMSOS CLUL1 RNU1-109P ENSG00000265490 piR-61961 lnc-YES1-7
GH18J000474 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -121.3 -121288 3 TEAD4 REST TEAD1 CTCF SAP130 ETS1 SMAD4 FOS JUND FOSL2 COLEC12 CLUL1 CETN1 THOC1 USP14 piR-33614-123
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLUL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLUL1

Top Transcription factor binding sites by QIAGEN in the CLUL1 gene promoter:
  • Bach2
  • FOXO4
  • GATA-6
  • Gfi-1
  • Ik-2
  • IRF-2
  • Pax-3
  • Sp1
  • SRF
  • SRF (504 AA)

Genomic Locations for CLUL1 Gene

Genomic Locations for CLUL1 Gene
chr18:596,988-650,334
(GRCh38/hg38)
Size:
53,347 bases
Orientation:
Plus strand
chr18:596,988-650,334
(GRCh37/hg19)
Size:
53,347 bases
Orientation:
Plus strand

Genomic View for CLUL1 Gene

Genes around CLUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLUL1 Gene

Proteins for CLUL1 Gene

  • Protein details for CLUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15846-CLUL1_HUMAN
    Recommended name:
    Clusterin-like protein 1
    Protein Accession:
    Q15846
    Secondary Accessions:
    • A0FDN7

    Protein attributes for CLUL1 Gene

    Size:
    466 amino acids
    Molecular mass:
    54215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLUL1 Gene

Post-translational modifications for CLUL1 Gene

  • Glycosylation at Asn196, Asn257, Asn311, Asn351, Asn412, and Asn431
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLUL1 Gene

Domains & Families for CLUL1 Gene

Gene Families for CLUL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CLUL1 Gene

Suggested Antigen Peptide Sequences for CLUL1 Gene

GenScript: Design optimal peptide antigens:
  • Clusterin-like 1 transcript variant 2 (A0FDN7_HUMAN)
  • Retinal-specific clusterin-like protein (CLUL1_HUMAN)
  • Clusterin (F5GWQ8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15846

UniProtKB/Swiss-Prot:

CLUL1_HUMAN :
  • Belongs to the clusterin family.
Family:
  • Belongs to the clusterin family.
genes like me logo Genes that share domains with CLUL1: view

Function for CLUL1 Gene

Phenotypes From GWAS Catalog for CLUL1 Gene

Gene Ontology (GO) - Molecular Function for CLUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051787 misfolded protein binding IBA 21873635
genes like me logo Genes that share ontologies with CLUL1: view
genes like me logo Genes that share phenotypes with CLUL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLUL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLUL1 Gene

Localization for CLUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLUL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLUL1 gene
Compartment Confidence
extracellular 3
nucleus 3
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with CLUL1: view

Pathways & Interactions for CLUL1 Gene

PathCards logo

SuperPathways for CLUL1 Gene

No Data Available

Interacting Proteins for CLUL1 Gene

;

Gene Ontology (GO) - Biological Process for CLUL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLUL1 Gene

Drugs & Compounds for CLUL1 Gene

No Compound Related Data Available

Transcripts for CLUL1 Gene

mRNA/cDNA for CLUL1 Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLUL1

Alternative Splicing Database (ASD) splice patterns (SP) for CLUL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5: - -
SP6: -

Relevant External Links for CLUL1 Gene

GeneLoc Exon Structure for
CLUL1

Expression for CLUL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLUL1 Gene

Protein differential expression in normal tissues from HIPED for CLUL1 Gene

This gene is overexpressed in Vitreous humor (42.4), Plasma (17.9), and Retina (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLUL1 Gene



Protein tissue co-expression partners for CLUL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLUL1

SOURCE GeneReport for Unigene cluster for CLUL1 Gene:

Hs.732341

Evidence on tissue expression from TISSUES for CLUL1 Gene

  • Eye(4.7)
  • Nervous system(4.7)
  • Lung(2.9)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with CLUL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLUL1 Gene

Orthologs for CLUL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLUL1 31 30
  • 99.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CLUL1 31 30
  • 85.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CLUL1 31 30
  • 82.29 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clul1 30
  • 75.79 (n)
oppossum
(Monodelphis domestica)
Mammalia CLUL1 31
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLUL1 31
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLUL1 31 30
  • 64.52 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLUL1 31
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clul1 30
  • 50.91 (n)
zebrafish
(Danio rerio)
Actinopterygii clul1 31 30
  • 46.8 (n)
OneToOne
Species where no ortholog for CLUL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLUL1 Gene

ENSEMBL:
Gene Tree for CLUL1 (if available)
TreeFam:
Gene Tree for CLUL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLUL1: view image

Paralogs for CLUL1 Gene

Paralogs for CLUL1 Gene

(23) SIMAP similar genes for CLUL1 Gene using alignment to 5 proteins:

  • CLUL1_HUMAN
  • F5GWQ8_HUMAN
  • J3QKW8_HUMAN
  • R4GN76_HUMAN
  • R4GN95_HUMAN
genes like me logo Genes that share paralogs with CLUL1: view

Variants for CLUL1 Gene

Additional dbSNP identifiers (rs#s) for CLUL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CLUL1 Gene

Variant ID Type Subtype PubMed ID
dgv3307n100 CNV gain 25217958
dgv574e199 CNV deletion 23128226
dgv5810n54 CNV gain 21841781
esv1619817 CNV deletion 17803354
esv2663170 CNV deletion 23128226
esv2676596 CNV deletion 23128226
esv2716645 CNV deletion 23290073
esv2716646 CNV deletion 23290073
esv2716648 CNV deletion 23290073
esv2716649 CNV deletion 23290073
esv2716650 CNV deletion 23290073
esv3554939 CNV deletion 23714750
esv3582931 CNV loss 25503493
esv3582932 CNV loss 25503493
esv3641496 CNV loss 21293372
esv3641497 CNV gain 21293372
esv3641499 CNV loss 21293372
esv3641500 CNV loss 21293372
esv3641501 CNV loss 21293372
esv3641502 CNV loss 21293372
esv3641503 CNV gain 21293372
esv3641504 CNV loss 21293372
esv3893055 CNV gain 25118596
nsv1060188 CNV gain 25217958
nsv131524 CNV deletion 16902084
nsv482935 CNV loss 15286789
nsv528169 CNV loss 19592680
nsv576228 CNV loss 21841781
nsv576236 CNV gain 21841781
nsv576239 CNV gain 21841781
nsv576242 CNV gain 21841781
nsv576243 CNV gain 21841781
nsv576244 CNV loss 21841781
nsv833577 CNV gain+loss 17160897

Variation tolerance for CLUL1 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLUL1 Gene

Human Gene Mutation Database (HGMD)
CLUL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLUL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLUL1 Gene

Disorders for CLUL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLUL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myopia
  • near vision
- elite association - COSMIC cancer census association via MalaCards
Search CLUL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CLUL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CLUL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLUL1 Gene

Publications for CLUL1 Gene

  1. Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene. (PMID: 14507903) Zhang Q … Aguirre GD (Investigative ophthalmology & visual science 2003) 2 3 4 23 54
  2. Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA. (PMID: 10675623) Zhang Q … Aguirre GD (Gene 2000) 2 3 23 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  5. Mapping of transcription start sites of human retina expressed genes. (PMID: 17286855) Roni V … Wissinger B (BMC genomics 2007) 3 4 54

Products for CLUL1 Gene

Sources for CLUL1 Gene