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Aliases for CLUL1 Gene

Aliases for CLUL1 Gene

  • Clusterin Like 1 2 3 5
  • Retinal-Specific Clusterin-Like Protein 3 4
  • Retinal Clusterin-Like Protein 2 3
  • Clusterin-Like 1 (Retinal) 2 3
  • Clusterin-Like Protein 1 3
  • RA337M 3

External Ids for CLUL1 Gene

Previous GeneCards Identifiers for CLUL1 Gene

  • GC18P000880
  • GC18P000584
  • GC18P000586

Summaries for CLUL1 Gene

GeneCards Summary for CLUL1 Gene

CLUL1 (Clusterin Like 1) is a Protein Coding gene. An important paralog of this gene is CLU.

Additional gene information for CLUL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLUL1 Gene

Genomics for CLUL1 Gene

GeneHancer (GH) Regulatory Elements for CLUL1 Gene

Promoters and enhancers for CLUL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I000596 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 579.5 -0.1 -120 1.4 PKNOX1 ATF1 ARID4B SIN3A ZNF48 ZNF121 GLIS2 CBX5 ZNF213 ZNF143 CLUL1 RN7SKP146
GH18I000617 Promoter 1 EPDnew 550.4 +19.7 19691 0.1 CTCF NFATC3 ASH1L BMI1 RAD21 FOSL1 ZNF316 ZNF213 ARID2 ZNF143 CLUL1 CETN1 GC18P000629
GH18I000597 Enhancer 0.7 ENCODE 562.2 +1.2 1186 0.9 PKNOX1 ZSCAN26 ZBTB6 ZMYM3 FEZF1 ZNF335 ZNF121 ZNF664 CTBP1 ZNF366 CLUL1 THOC1 GC18P000629
GH18I000322 Enhancer 1.4 FANTOM5 Ensembl ENCODE 10.4 -274.3 -274279 1.2 ATF1 FOXA2 ARNT ZNF48 ETS1 TCF12 FOS ATF7 RUNX3 NCOA1 THOC1 ENSG00000264514 CETN1 CLUL1 GC18P000404 COLEC12
GH18I000679 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11 +86.4 86369 7.9 SOX13 PKNOX1 FOXA2 SIN3A ZNF384 ZIC2 ZFHX2 LCORL RERE POLR2A ENOSF1 TYMS TYMSOS CLUL1 RNU1-109P ENSG00000265490 GC18M000704 PIR56960
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLUL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLUL1 gene promoter:

Genomic Locations for CLUL1 Gene

Genomic Locations for CLUL1 Gene
53,347 bases
Plus strand

Genomic View for CLUL1 Gene

Genes around CLUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLUL1 Gene

Proteins for CLUL1 Gene

  • Protein details for CLUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Clusterin-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A0FDN7

    Protein attributes for CLUL1 Gene

    466 amino acids
    Molecular mass:
    54215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLUL1 Gene

Post-translational modifications for CLUL1 Gene

  • Glycosylation at posLast=196196, Asn257, posLast=311311, posLast=351351, posLast=412412, and Asn431
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLUL1 Gene

Domains & Families for CLUL1 Gene

Gene Families for CLUL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CLUL1 Gene

Suggested Antigen Peptide Sequences for CLUL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the clusterin family.
  • Belongs to the clusterin family.
genes like me logo Genes that share domains with CLUL1: view

Function for CLUL1 Gene

Phenotypes From GWAS Catalog for CLUL1 Gene

genes like me logo Genes that share phenotypes with CLUL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLUL1 Gene

Localization for CLUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLUL1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLUL1 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CLUL1: view

Pathways & Interactions for CLUL1 Gene

SuperPathways for CLUL1 Gene

No Data Available

Interacting Proteins for CLUL1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000341128 for CLUL1 Gene via STRING

Gene Ontology (GO) - Biological Process for CLUL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CLUL1 Gene

Drugs & Compounds for CLUL1 Gene

No Compound Related Data Available

Transcripts for CLUL1 Gene

Unigene Clusters for CLUL1 Gene

Clusterin-like 1 (retinal):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLUL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP3: - - - -
SP5: - -
SP6: -

Relevant External Links for CLUL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLUL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLUL1 Gene

Protein differential expression in normal tissues from HIPED for CLUL1 Gene

This gene is overexpressed in Vitreous humor (42.4), Plasma (17.9), and Retina (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLUL1 Gene

Protein tissue co-expression partners for CLUL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLUL1 Gene:


SOURCE GeneReport for Unigene cluster for CLUL1 Gene:


Evidence on tissue expression from TISSUES for CLUL1 Gene

  • Eye(4.7)
  • Nervous system(4.7)
  • Lung(2.9)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with CLUL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLUL1 Gene

Orthologs for CLUL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLUL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLUL1 33 34
  • 99.1 (n)
(Canis familiaris)
Mammalia CLUL1 33 34
  • 85.38 (n)
(Bos Taurus)
Mammalia CLUL1 33 34
  • 82.29 (n)
(Rattus norvegicus)
Mammalia Clul1 33
  • 75.79 (n)
(Monodelphis domestica)
Mammalia CLUL1 34
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia CLUL1 34
  • 45 (a)
(Gallus gallus)
Aves CLUL1 33 34
  • 64.52 (n)
(Anolis carolinensis)
Reptilia CLUL1 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clul1 33
  • 50.91 (n)
(Danio rerio)
Actinopterygii clul1 33 34
  • 46.8 (n)
Species where no ortholog for CLUL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLUL1 Gene

Gene Tree for CLUL1 (if available)
Gene Tree for CLUL1 (if available)

Paralogs for CLUL1 Gene

Paralogs for CLUL1 Gene

genes like me logo Genes that share paralogs with CLUL1: view

Variants for CLUL1 Gene

Sequence variations from dbSNP and Humsavar for CLUL1 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000025117 -- 621,793(+) G/A intron_variant
rs1000039245 -- 646,474(+) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000040792 -- 642,361(+) G/A intron_variant
rs1000107593 -- 648,132(+) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000200696 -- 615,615(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLUL1 Gene

Variant ID Type Subtype PubMed ID
dgv3307n100 CNV gain 25217958
dgv574e199 CNV deletion 23128226
dgv5810n54 CNV gain 21841781
esv1619817 CNV deletion 17803354
esv2663170 CNV deletion 23128226
esv2676596 CNV deletion 23128226
esv2716645 CNV deletion 23290073
esv2716646 CNV deletion 23290073
esv2716648 CNV deletion 23290073
esv2716649 CNV deletion 23290073
esv2716650 CNV deletion 23290073
esv3554939 CNV deletion 23714750
esv3582931 CNV loss 25503493
esv3582932 CNV loss 25503493
esv3641496 CNV loss 21293372
esv3641497 CNV gain 21293372
esv3641499 CNV loss 21293372
esv3641500 CNV loss 21293372
esv3641501 CNV loss 21293372
esv3641502 CNV loss 21293372
esv3641503 CNV gain 21293372
esv3641504 CNV loss 21293372
esv3893055 CNV gain 25118596
nsv1060188 CNV gain 25217958
nsv131524 CNV deletion 16902084
nsv482935 CNV loss 15286789
nsv528169 CNV loss 19592680
nsv576228 CNV loss 21841781
nsv576236 CNV gain 21841781
nsv576239 CNV gain 21841781
nsv576242 CNV gain 21841781
nsv576243 CNV gain 21841781
nsv576244 CNV loss 21841781
nsv833577 CNV gain+loss 17160897

Variation tolerance for CLUL1 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLUL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLUL1 Gene

Disorders for CLUL1 Gene

Additional Disease Information for CLUL1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CLUL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLUL1 Gene

Publications for CLUL1 Gene

  1. Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene. (PMID: 14507903) Zhang Q … Aguirre GD (Investigative ophthalmology & visual science 2003) 2 3 4 22 58
  2. Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA. (PMID: 10675623) Zhang Q … Aguirre GD (Gene 2000) 2 3 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Mapping of transcription start sites of human retina expressed genes. (PMID: 17286855) Roni V … Wissinger B (BMC genomics 2007) 3 4 58

Products for CLUL1 Gene

Sources for CLUL1 Gene

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