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This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide... See more...
Aliases for CLTRN Gene
Aliases for CLTRN Gene
External Ids for CLTRN Gene
- HGNC: 29437
- Entrez Gene: 57393
- Ensembl: ENSG00000147003
- OMIM: 300631
- UniProtKB: Q9HBJ8
Previous HGNC Symbols for CLTRN Gene
- TMEM27
Summaries for CLTRN Gene
-
This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]
GeneCards Summary for CLTRN Gene
CLTRN (Collectrin, Amino Acid Transport Regulator) is a Protein Coding gene. Diseases associated with CLTRN include Aminoaciduria and Hartnup Disorder. Among its related pathways are Metabolism of proteins and Peptide hormone metabolism. An important paralog of this gene is ENSG00000285602.
UniProtKB/Swiss-Prot Summary for CLTRN Gene
-
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (PubMed:16330323).
Additional gene information for CLTRN Gene
- HGNC(29437)
- Entrez Gene(57393)
- Ensembl(ENSG00000147003)
- OMIM(300631)
- UniProtKB(Q9HBJ8)
- Open Targets Platform(ENSG00000147003)
- Monarch Initiative
- Search for CLTRN at DataMed
- Search for CLTRN at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLTRN Gene
Genomics for CLTRN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CLTRN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CLTRN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLTRN
Genomic Locations for CLTRN Gene
Genomic Locations for CLTRN Gene
- chrX:15,627,318-15,675,624
- (GRCh38/hg38)
- Size:
- 48,307 bases
- Orientation:
- Minus strand
- chrX:15,645,441-15,683,154
- (GRCh37/hg19)
- Size:
- 37,714 bases
- Orientation:
- Minus strand
Genomic View for CLTRN Gene
Genes around CLTRN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by HGNC
- Xp22.2 by Entrez Gene
- Xp22.2 by Ensembl
CLTRN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLTRN Gene
Proteins for CLTRN Gene
-
Protein details for CLTRN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HBJ8-CLTRN_HUMAN
- Recommended name:
- Collectrin
- Protein Accession:
- Q9HBJ8
- B2R9M1
- Q6UW07
Protein attributes for CLTRN Gene
- Size:
- 222 amino acids
- Molecular mass:
- 25235 Da
- Quaternary structure:
-
- Monomer (PubMed:22628310). Homodimer; dimerization prevents CLTRN cleavage by BACE2 (PubMed:22628310). Interacts with SLC6A18; this interaction regulates the trafficking of SLC6A18 to the cell membrane and its amino acid transporter activity (By similarity). Interacts with SLC6A19; this interaction regulates the trafficking of SLC6A19 to the cell membrane and its amino acid transporter activity (By similarity). Interacts with SNAPIN (PubMed:16330323).
- SequenceCaution:
-
- Sequence=AAQ89419.1; Type=Frameshift; Evidence={ECO:0000305};
Post-translational modifications for CLTRN Gene
- Glycosylated. Glycosylation is required for plasma membrane localization and for its cleavage by BACE2.
- Proteolytically processed in pancreatic beta cells by BACE2 leading to the generation and extracellular release of soluble CLTRN, and a corresponding cell-associated C-terminal fragment which is later cleaved by gamma-secretase. This shedding process inactivates CLTRN (By similarity). Three cleavage sites have been identified for BACE2, two clustered sites after Phe-116 and Leu-118 and a more membrane proximal site at Phe-125; the preferred BACE2 cleavage site seems to be between Phe-125 and Leu-126, Phe-116 and Leu-118 act as alternative sites (PubMed:21907142, PubMed:22628310).
-
Glycosylation at Asn76 and Asn93
- NX_Q9HBJ8 (NX_Q9HBJ8-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CLTRN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences TMEM27 / Collectrin Antibody
- Novus Biologicals Antibodies for CLTRN
-
Abcam antibodies for CLTRN
- Invitrogen Antibodies for CLTRN (AFLGC-TMEM27)
-
Biorbyt antibodies for CLTRN
- Sino Biological Antibodies for CLTRN
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CLTRN
- Origene Custom Protein Services for CLTRN
- Sino Biological Recombinant Proteins for CLTRN
- Sino Biological Cell Lysates for CLTRN
- ProSpec Recombinant Proteins for CLTRN
-
Abcam proteins for CLTRN
Assay Products
- antibodies-online: Show 24 available TMEM27 Elisa Kits ranked by validation data
- Compare Top TMEM27 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CLTRN Gene
Domains & Families for CLTRN Gene
Gene Families for CLTRN Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for CLTRN Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CLTRN Gene
- GenScript: Design optimal peptide antigens:
-
- Transmembrane protein 27 (TMM27_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9HBJ8UniProtKB/Swiss-Prot:
CLTRN_HUMAN :- The cleavage site containing the double Phe-Phe motif acts as negative regulator of shedding by BACE2.
- Belongs to the CLTRN family.
- Domain:
-
- The cleavage site containing the double Phe-Phe motif acts as negative regulator of shedding by BACE2.
- Family:
-
- Belongs to the CLTRN family.
Function for CLTRN Gene
Molecular function for CLTRN Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (PubMed:16330323).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16330323 |
| GO:0042803 | protein homodimerization activity | IDA | 22628310 |
Phenotypes for CLTRN Gene
- MGI mutant phenotypes for CLTRN:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CLTRN:
Animal Model Products
-
Taconic Biosciences Mouse Models for CLTRN
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLTRN - Select products 50% OFF >
- * CLTRN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CLTRN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLTRN
- Browse OriGene Inhibitory RNA Products For CLTRN
Clone Products
- Applied Biological Materials (abm): Clones for CLTRN - Select products 50% OFF >
- * CLTRN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for CLTRN
Cell Line Products
-
Horizon Cell Lines for CLTRN
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLTRN Gene
Localization for CLTRN Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLTRN Gene
- Cell membrane. Single-pass type I membrane protein. Note=Localizes to the brush border membranes of cells in the proximal tubules of kidney (By similarity). Colocalizes with SLC6A19 in the early proximal S1 tubule (By similarity). {ECO:0000250 UniProtKB:Q9ESG4}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Endoplasmic reticulum (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 16330323 |
| GO:0005886 | plasma membrane | IEA,IDA | 21907142 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for CLTRN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide hormone metabolism | ||
| 2 | Metabolism of proteins | ||
Pathways by source for CLTRN Gene
3 Reactome pathways for CLTRN Gene
Interacting Proteins for CLTRN Gene
Selected Interacting proteins:
Q9HBJ8-CLTRN_HUMAN
ENSP00000369699
for CLTRN Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CLTRN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035543 | positive regulation of SNARE complex assembly | IDA | 16330323 |
| GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus | IDA | 16330323 |
| GO:0045956 | positive regulation of calcium ion-dependent exocytosis | IDA | 16330323 |
| GO:0051957 | positive regulation of amino acid transport | IBA | 21873635 |
No data available for SIGNOR curated interactions for CLTRN Gene
Transcripts for CLTRN Gene
mRNA/cDNA for CLTRN Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000380342 1352 nts (view in UCSC)
- ENST00000650271 1574 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLTRN - Select products 50% OFF >
- * CLTRN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CLTRN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLTRN
- Browse OriGene Inhibitory RNA Products For CLTRN
Clone Products
- Applied Biological Materials (abm): Clones for CLTRN - Select products 50% OFF >
- * CLTRN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CLTRN
Relevant External Links for CLTRN Gene
- GeneLoc Exon Structure for
- CLTRN
Expression for CLTRN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Presumptive Podocytes Podocyte Layer
- Proximal Tubule Cells Proximal Tubule
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
- Proximal Tubule Cells Proximal Tubule
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
-
Eye (Sensory Organs)
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
-
Neurons
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
- Intermediate Mesoderm (Gastrulation Derivatives)
-
Testis (Reproductive System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLTRN
mRNA Expression by UniProt/SwissProt for CLTRN Gene:
Q9HBJ8-CLTRN_HUMAN
Tissue specificity:
Kidney; collecting ducts. Pancreas; beta cells of islets.
Evidence on tissue expression from TISSUES for CLTRN Gene
- Kidney(4.8)
- Intestine(4.3)
- Bone marrow(4)
- Liver(2.4)
- Pancreas(2.2)
Primer Products
-
OriGene qPCR primer pairs for CLTRN
-
OriGene qPCR primer pairs and template standards for CLTRN
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLTRN Gene
Orthologs for CLTRN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TMEM27 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TMEM27 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TMEM27 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Tmem27 30 31 |
|
OneToOne | |
| Cltrn 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Tmem27 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TMEM27 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TMEM27 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TMEM27 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TMEM27 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tmem27 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68634 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-194e6.1 30 |
|
||
| TMEM27 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ance-2 31 |
|
OneToMany | |
| Ance-4 31 |
|
OneToMany | |||
| Ance-5 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | acn-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
- Species where no ortholog for CLTRN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CLTRN Gene
- ENSEMBL:
- Gene Tree for CLTRN (if available)
- TreeFam:
- Gene Tree for CLTRN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CLTRN: view image
Paralogs for CLTRN Gene
Paralogs for CLTRN Gene
Variants for CLTRN Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758862 | CNV | loss | 17122850 |
Residual Variation Intolerance Score:
21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.43;
9.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLTRN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CLTRN
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLTRN Gene
Disorders for CLTRN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| aminoaciduria |
|
|
| hartnup disorder |
|
|
| fanconi-like syndrome |
|
|
| maturity-onset diabetes of the young, type 3 |
|
|
| renal cysts and diabetes syndrome |
|
|
Search CLTRN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CLTRN
No data available for UniProtKB/Swiss-Prot and Genatlas for CLTRN Gene
Publications for CLTRN Gene
- Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys. (PMID: 11278314) Zhang H … Makino H (The Journal of biological chemistry 2001) 2 3 4 23
- Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2. (PMID: 22628310) Esterházy D … Stoffel M (Biological chemistry 2012) 3 4
- Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass. (PMID: 21907142) Esterházy D … Stoffel M (Cell metabolism 2011) 3 4
- Not just angiotensinases: new roles for the angiotensin-converting enzymes. (PMID: 19763395) Lambert DW … Turner AJ (Cellular and molecular life sciences : CMLS 2010) 3 23
- The role of transmembrane protein 27 (TMEM27) in islet physiology and its potential use as a beta cell mass biomarker. (PMID: 20386877) Altirriba J … Gomis R (Diabetologia 2010) 3 23
ExternalLinks
Products for CLTRN Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CLTRN
- Origene Custom Protein Services for CLTRN
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLTRN
- Browse OriGene Inhibitory RNA Products For CLTRN
- OriGene qPCR primer pairs for CLTRN
- OriGene qPCR primer pairs and template standards for CLTRN
- OriGene CRISPR knockouts for CLTRN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CLTRN
- Sino Biological Human cDNA Clone for CLTRN
- Sino Biological Recombinant Proteins for CLTRN
- Sino Biological Cell Lysates for CLTRN
- Sino Biological Antibodies for CLTRN
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CLTRN
- Novus Biologicals proteins and lysates for CLTRN
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for CLTRN
- Abcam proteins for CLTRN
- Find your target
- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for CLTRN
- Taconic Biosciences Mouse Models for CLTRN
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CLTRN (AFLGC-TMEM27)
- VectorBuilder Custom and pre-made DNA vectors for CLTRN (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CLTRN (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CLTRN (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CLTRN CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CLTRN
- antibodies-online: Show 7 available TMEM27 Antibodies ranked by validation data
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- antibodies-online: Show 24 available TMEM27 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 17 available TMEM27 Proteins ranked by validation data
- Compare Top TMEM27 Proteins
- Horizon Cell Lines for CLTRN
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for CLTRN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for CLTRN
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CLTRN
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for CLTRN
Sources for CLTRN Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
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