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This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 20... See more...
Aliases for CLTCL1 Gene
Aliases for CLTCL1 Gene
External Ids for CLTCL1 Gene
- HGNC: 2093
- Entrez Gene: 8218
- Ensembl: ENSG00000070371
- OMIM: 601273
- UniProtKB: P53675
Previous HGNC Symbols for CLTCL1 Gene
- CLTCL
Previous GeneCards Identifiers for CLTCL1 Gene
- GC22M016107
- GC22M017541
- GC22M002788
Summaries for CLTCL1 Gene
-
This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
GeneCards Summary for CLTCL1 Gene
CLTCL1 (Clathrin Heavy Chain Like 1) is a Protein Coding gene. Diseases associated with CLTCL1 include Congenital Insensitivity To Pain With Severe Intellectual Disability and Chromosome 22Q11.2 Duplication Syndrome. Among its related pathways are Lysosome and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include binding and structural molecule activity. An important paralog of this gene is CLTC.
UniProtKB/Swiss-Prot Summary for CLTCL1 Gene
-
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).
Additional gene information for CLTCL1 Gene
- HGNC(2093)
- Entrez Gene(8218)
- Ensembl(ENSG00000070371)
- OMIM(601273)
- UniProtKB(P53675)
- Open Targets Platform(ENSG00000070371)
- Monarch Initiative
- Search for CLTCL1 at DataMed
- Search for CLTCL1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLTCL1 Gene
Genomics for CLTCL1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CLTCL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CLTCL1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLTCL1
- Top Transcription factor binding sites by QIAGEN in the CLTCL1 gene promoter:
-
- NRSF form 1
- NRSF form 2
Genomic Locations for CLTCL1 Gene
Genomic Locations for CLTCL1 Gene
- chr22:19,179,473-19,291,719
- (GRCh38/hg38)
- Size:
- 112,247 bases
- Orientation:
- Minus strand
- chr22:19,166,986-19,279,239
- (GRCh37/hg19)
- Size:
- 112,254 bases
- Orientation:
- Minus strand
Genomic View for CLTCL1 Gene
Genes around CLTCL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by HGNC
- 22q11.21 by Entrez Gene
- 22q11.21 by Ensembl
CLTCL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLTCL1 Gene
Proteins for CLTCL1 Gene
-
Protein details for CLTCL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53675-CLH2_HUMAN
- Recommended name:
- Clathrin heavy chain 2
- Protein Accession:
- P53675
- B7Z7U5
- Q14017
- Q15808
- Q15809
Protein attributes for CLTCL1 Gene
- Size:
- 1640 amino acids
- Molecular mass:
- 187030 Da
- Quaternary structure:
-
- Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium (By similarity). May interact with OCRL (By similarity).
Protein Expression for CLTCL1 Gene
Post-translational modifications for CLTCL1 Gene
Other Protein References for CLTCL1 Gene
Antibody Products
- Novus Biologicals Antibodies for CLTCL1
- Invitrogen Antibodies for CLTCL1 (AFLGC-CLTCL1)
-
Boster Bio Antibodies for CLTCL1
Protein Products
-
OriGene Purified Proteins for CLTCL1
- Search Origene for MassSpec and Protein Over-expression Lysates for CLTCL1
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- Novus Biologicals proteins for CLTCL1
No data available for DME Specific Peptides for CLTCL1 Gene
Domains & Families for CLTCL1 Gene
Gene Families for CLTCL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CLTCL1 Gene
- InterPro:
- Blocks:
-
- 7-Fold repeat in clathrin and VPS proteins
- ProtoNet:
Suggested Antigen Peptide Sequences for CLTCL1 Gene
- GenScript: Design optimal peptide antigens:
-
- CLTCL1 protein (A4FU99_HUMAN)
- Clathrin heavy chain on chromosome 22 (CLH2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P53675UniProtKB/Swiss-Prot:
CLH2_HUMAN :- The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
- Belongs to the clathrin heavy chain family.
- Domain:
-
- The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
- The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node (By similarity).
- Family:
-
- Belongs to the clathrin heavy chain family.
Function for CLTCL1 Gene
Molecular function for CLTCL1 Gene
- UniProtKB/Swiss-Prot Function:
- Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).
- GENATLAS Biochemistry:
- clathrin heavy chain-like sequence in the DiGeorge critical region (DGCR)
Phenotypes From GWAS Catalog for CLTCL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 19478182 |
| GO:0032051 | clathrin light chain binding | IEA,IBA | 21873635 |
Phenotypes for CLTCL1 Gene
Animal Model Products
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CRISPR Products
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for CLTCL1 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for CLTCL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLTCL1
Cell Line Products
-
Horizon Cell Lines for CLTCL1
No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLTCL1 Gene
Localization for CLTCL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLTCL1 Gene
- Cytoplasmic vesicle membrane. Peripheral membrane protein. Cytoplasmic side. Membrane, coated pit. Peripheral membrane protein. Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| endosome | 5 |
| golgi apparatus | 5 |
| extracellular | 4 |
| cytosol | 4 |
| plasma membrane | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005769 | NOT early endosome | IDA | 20065094 |
| GO:0005770 | late endosome | IDA | 20065094 |
| GO:0005802 | trans-Golgi network | IDA | 19509056 |
| GO:0005819 | spindle | IDA | 19509056 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for CLTCL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gap junction trafficking | ||
| 2 | Synaptic vesicle cycle | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Clathrin-mediated endocytosis | ||
| 5 | EPH-Ephrin signaling | ||
Pathways by source for CLTCL1 Gene
1 BioSystems pathway for CLTCL1 Gene
12 Reactome pathways for CLTCL1 Gene
6 KEGG pathways for CLTCL1 Gene
1 R&D Systems pathway for CLTCL1 Gene
Interacting Proteins for CLTCL1 Gene
Selected Interacting proteins:
P53675-CLH2_HUMAN
ENSP00000441158
for CLTCL1 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for CLTCL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000278 | NOT mitotic cell cycle | IDA | 20065094 |
| GO:0006886 | intracellular protein transport | IEA | -- |
| GO:0006898 | receptor-mediated endocytosis | TAS,IDA | 19509056 |
| GO:0009653 | anatomical structure morphogenesis | TAS | 8733128 |
| GO:0016192 | vesicle-mediated transport | IEA | -- |
Transcripts for CLTCL1 Gene
mRNA/cDNA for CLTCL1 Gene
- 2 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000621271 5313 nts (view in UCSC)
- ENST00000427926 5518 nts (view in UCSC)
- ENST00000412649 4635 nts (view in UCSC)
- ENST00000622493 1714 nts (view in UCSC)
- ENST00000617926 1695 nts (view in UCSC)
CRISPR Products
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for CLTCL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLTCL1
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Clone Products
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- Sino Biological Human cDNA Clone for CLTCL1
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| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32a | · | 32b | ^ | 33 | ^ | 34a | · | 34b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for CLTCL1 Gene
- GeneLoc Exon Structure for
- CLTCL1
Expression for CLTCL1 Gene
mRNA differential expression in normal tissues according to GTEx for CLTCL1 Gene
This gene is overexpressed in Muscle - Skeletal (x22.2).
This gene is overexpressed in Brain (44.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CLTCL1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLTCL1
SOURCE GeneReport for Unigene cluster for CLTCL1 Gene:
Hs.368266mRNA Expression by UniProt/SwissProt for CLTCL1 Gene:
P53675-CLH2_HUMAN
Tissue specificity:
Maximal levels in skeletal muscle. High levels in heart and testis. Low expression detected in all other tissues.
Evidence on tissue expression from TISSUES for CLTCL1 Gene
- Muscle(4.5)
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs for CLTCL1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLTCL1 Gene
Orthologs for CLTCL1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CLTCL1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CLTCL1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CLTCL1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CLTCL1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CLTCL1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100492311 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CLTCL1 (2 of 2) 31 |
|
OneToMany | |
| CLTCL1 (1 of 2) 31 |
|
OneToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.619 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Chc 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | chc-1 31 |
|
OneToMany | |
| T20G5.1 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CHC1 31 |
|
OneToMany | |
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.5152 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.12119 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1583 31 |
|
OneToMany |
- Species where no ortholog for CLTCL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Cow (Bos Taurus)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CLTCL1 Gene
- ENSEMBL:
- Gene Tree for CLTCL1 (if available)
- TreeFam:
- Gene Tree for CLTCL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CLTCL1: view image
Paralogs for CLTCL1 Gene
Variants for CLTCL1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLTCL1 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708745 | Likely Benign: not provided | 19,234,536(-) | G/A | SYNONYMOUS_VARIANT | |
| 716364 | Benign: not provided | 19,183,443(-) | C/G | MISSENSE_VARIANT | |
| 716365 | Benign: not provided | 19,232,468(-) | A/G | INTRON_VARIANT | |
| 716366 | Benign: not provided | 19,232,542(-) | C/T | SYNONYMOUS_VARIANT | |
| 718483 | Likely Benign: not provided | 19,183,561(-) | C/CT | FRAMESHIFT_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1007063 | CNV | deletion | 20482838 |
| esv2532331 | CNV | insertion | 19546169 |
| esv2664681 | CNV | deletion | 23128226 |
| esv2672843 | CNV | deletion | 23128226 |
| esv2676900 | CNV | deletion | 23128226 |
| esv3307775 | CNV | mobile element insertion | 20981092 |
| esv3308015 | CNV | mobile element insertion | 20981092 |
| esv3308782 | CNV | mobile element insertion | 20981092 |
| esv3387591 | CNV | insertion | 20981092 |
| esv3575418 | CNV | gain | 25503493 |
| esv3647265 | CNV | loss | 21293372 |
| esv3647268 | CNV | loss | 21293372 |
| esv3647269 | CNV | loss | 21293372 |
| nsv1116942 | CNV | deletion | 24896259 |
| nsv1125751 | CNV | tandem duplication | 24896259 |
| nsv1143025 | CNV | tandem duplication | 24896259 |
| nsv459398 | CNV | loss | 19166990 |
| nsv513584 | CNV | insertion | 21212237 |
| nsv588213 | CNV | gain | 21841781 |
| nsv588216 | CNV | gain | 21841781 |
| nsv588217 | CNV | loss | 21841781 |
| nsv828933 | CNV | loss | 20364138 |
| nsv834122 | CNV | loss | 17160897 |
| nsv834123 | CNV | loss | 17160897 |
| nsv834124 | CNV | loss | 17160897 |
| nsv834125 | CNV | loss | 17160897 |
| nsv979633 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
17.78;
98.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLTCL1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLTCL1 Gene
Disorders for CLTCL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital insensitivity to pain with severe intellectual disability |
|
|
| chromosome 22q11.2 duplication syndrome |
|
|
| digeorge syndrome |
|
|
| ichthyosis, congenital, autosomal recessive 9 |
|
|
| crouzon syndrome with acanthosis nigricans |
|
|
Search CLTCL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CLTCL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CLTCL1 Gene
Publications for CLTCL1 Gene
- Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL). (PMID: 8844170) Long KR … Buckler AJ (Genomics 1996) 2 3 4
- Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome. (PMID: 8733128) Sirotkin H … Kucherlapati R (Human molecular genetics 1996) 3 4 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. (PMID: 15133132) Towler MC … Brodsky FM (Molecular biology of the cell 2004) 2 3
ExternalLinks
Products for CLTCL1 Gene
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLTCL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLTCL1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CLTCL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLTCL1
- Boster Bio Antibodies for CLTCL1
- Browse Boster Bio ELISA Kits
Sources for CLTCL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB