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Aliases for CLPSL2 Gene

Aliases for CLPSL2 Gene

  • Colipase Like 2 2 3 5
  • C6orf126 3 4
  • Chromosome 6 Open Reading Frame 126 2
  • Colipase-Like Protein C6orf126 3
  • Colipase-Like Protein 2 3
  • Colipase-Like 2 2
  • DJ510O8.5 3
  • AAAL3045 3
  • UNQ3045 3

External Ids for CLPSL2 Gene

Previous HGNC Symbols for CLPSL2 Gene

  • C6orf126

Previous GeneCards Identifiers for CLPSL2 Gene

  • GC06P035745
  • GC06P035859
  • GC06P036313
  • GC06P037300
  • GC06P036831
  • GC06P036912
  • GC06P037775
  • GC06P038399
  • GC06P038989
  • GC06P039578
  • GC06P040138

Summaries for CLPSL2 Gene

GeneCards Summary for CLPSL2 Gene

CLPSL2 (Colipase Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include enzyme activator activity.

Additional gene information for CLPSL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPSL2 Gene

Genomics for CLPSL2 Gene

GeneHancer (GH) Regulatory Elements for CLPSL2 Gene

Promoters and enhancers for CLPSL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I035776 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 558.9 +0.0 44 0.7 CLOCK SIN3A GLIS2 EGR1 ZNF366 ZNF280D USF2 ZNF398 ELF1 ZFP69B CLPSL2 CLPS ENSG00000232909 ARMC12 FKBP5 CLPSL1 GC06M038606
GH06I035796 Promoter 0.7 EPDnew 7.8 +20.4 20357 0.1 NRF1 KDM1A CLPS LHFPL5 CLPSL2 SRPK1 CLPSL1 GC06M038606
GH06I035757 Enhancer 0.6 ENCODE 4.6 -18.9 -18851 0.6 CTCF ZNF511 CBFB REST RAD21 KAT8 TEAD3 ZNF335 ZSCAN5C ZNF143 CLPSL2 LOC100652794 LOC285847 ENSG00000232909 GC06M038606
GH06I035780 Promoter 0.5 EPDnew 0.8 +4.4 4419 0.1 CLPSL1 CLPSL2 GC06M038606
GH06I035770 Enhancer 0.3 ENCODE 0.4 -5.6 -5635 0.2 MAFG ENSG00000228559 CLPSL2 LOC100652794 GC06M038606
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLPSL2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CLPSL2 Gene

Genomic Locations for CLPSL2 Gene
chr6:35,776,594-35,779,552
(GRCh38/hg38)
Size:
2,959 bases
Orientation:
Plus strand
chr6:35,744,371-35,747,329
(GRCh37/hg19)

Genomic View for CLPSL2 Gene

Genes around CLPSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLPSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLPSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPSL2 Gene

Proteins for CLPSL2 Gene

  • Protein details for CLPSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWE3-COLL2_HUMAN
    Recommended name:
    Colipase-like protein 2
    Protein Accession:
    Q6UWE3
    Secondary Accessions:
    • B0QZ45
    • Q5T9G3

    Protein attributes for CLPSL2 Gene

    Size:
    100 amino acids
    Molecular mass:
    10812 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLPSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLPSL2 Gene

Post-translational modifications for CLPSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLPSL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLPSL2 Gene

Domains & Families for CLPSL2 Gene

Gene Families for CLPSL2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CLPSL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLPSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWE3

UniProtKB/Swiss-Prot:

COLL2_HUMAN :
  • Belongs to the colipase family.
Family:
  • Belongs to the colipase family.
genes like me logo Genes that share domains with CLPSL2: view

Function for CLPSL2 Gene

Gene Ontology (GO) - Molecular Function for CLPSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with CLPSL2: view

Phenotypes for CLPSL2 Gene

genes like me logo Genes that share phenotypes with CLPSL2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLPSL2 Gene

Localization for CLPSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPSL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLPSL2 gene
Compartment Confidence
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CLPSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CLPSL2: view

Pathways & Interactions for CLPSL2 Gene

SuperPathways for CLPSL2 Gene

No Data Available

Interacting Proteins for CLPSL2 Gene

Selected Interacting proteins: Q6UWE3-COLL2_HUMAN for CLPSL2 Gene via UniProtKB

Symbol External ID(s) Details
UBQLN2

Gene Ontology (GO) - Biological Process for CLPSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion IEA --
GO:0016042 lipid catabolic process IEA --
GO:0032094 response to food IBA --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with CLPSL2: view

No data available for Pathways by source and SIGNOR curated interactions for CLPSL2 Gene

Drugs & Compounds for CLPSL2 Gene

No Compound Related Data Available

Transcripts for CLPSL2 Gene

mRNA/cDNA for CLPSL2 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLPSL2 Gene

Colipase-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLPSL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
SP1: -
SP2: -

Relevant External Links for CLPSL2 Gene

GeneLoc Exon Structure for
CLPSL2
ECgene alternative splicing isoforms for
CLPSL2

Expression for CLPSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLPSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLPSL2 Gene

This gene is overexpressed in Pancreas (x28.6) and Brain - Anterior cingulate cortex (BA24) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of CLPSL2 Gene:

CLPSL2

SOURCE GeneReport for Unigene cluster for CLPSL2 Gene:

Hs.259563
genes like me logo Genes that share expression patterns with CLPSL2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLPSL2 Gene

Orthologs for CLPSL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLPSL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLPSL2 33 34
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia CLPSL2 33 34
  • 74.46 (n)
cow
(Bos Taurus)
Mammalia CLPSL2 33
  • 74.23 (n)
mouse
(Mus musculus)
Mammalia Clpsl2 33 16 34
  • 70.27 (n)
rat
(Rattus norvegicus)
Mammalia Clpsl2 33
  • 65.02 (n)
Species where no ortholog for CLPSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLPSL2 Gene

ENSEMBL:
Gene Tree for CLPSL2 (if available)
TreeFam:
Gene Tree for CLPSL2 (if available)

Paralogs for CLPSL2 Gene

No data available for Paralogs for CLPSL2 Gene

Variants for CLPSL2 Gene

Sequence variations from dbSNP and Humsavar for CLPSL2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000061537 -- 35,775,395(+) A/G upstream_transcript_variant
rs1000255306 -- 35,775,654(+) C/G upstream_transcript_variant
rs1001672311 -- 35,777,093(+) C/T intron_variant
rs1001767047 -- 35,777,315(+) G/A intron_variant
rs1001824197 -- 35,776,232(+) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLPSL2 Gene

Variant ID Type Subtype PubMed ID
esv2759420 CNV gain 17122850
esv2762585 CNV gain 21179565
esv3608689 CNV gain 21293372
esv3890842 CNV gain 25118596
nsv428143 CNV gain 18775914
nsv524941 CNV loss 19592680
nsv525686 CNV gain 19592680
nsv602924 CNV gain 21841781
nsv7891 CNV gain 18304495
nsv821646 CNV loss 15273396

Variation tolerance for CLPSL2 Gene

Gene Damage Index Score: 5.92; 74.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLPSL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLPSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLPSL2 Gene

Disorders for CLPSL2 Gene

Additional Disease Information for CLPSL2

No disorders were found for CLPSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLPSL2 Gene

Publications for CLPSL2 Gene

  1. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 58

Products for CLPSL2 Gene

Sources for CLPSL2 Gene

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