Aliases for CLPS Gene
External Ids for CLPS Gene
Previous GeneCards Identifiers for CLPS Gene
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for CLPS Gene
CLPS (Colipase) is a Protein Coding gene. Diseases associated with CLPS include Johanson-Blizzard Syndrome and Pancreatic Steatorrhea. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include enzyme activator activity. An important paralog of this gene is CLPSL1.
UniProtKB/Swiss-Prot Summary for CLPS Gene
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.