This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively spli... See more...

Aliases for CLP1 Gene

Aliases for CLP1 Gene

  • Cleavage And Polyadenylation Factor I Subunit 1 2 3 5
  • Polyribonucleotide 5'-Hydroxyl-Kinase Clp1 3 4
  • Pre-MRNA Cleavage Complex II Protein Clp1 3 4
  • Polyadenylation Factor Clp1 3 4
  • Polynucleotide Kinase Clp1 3 4
  • EC 2.7.1.78 4 54
  • HEAB 3 4
  • CLP1, Cleavage And Polyadenylation Factor I Subunit, Homolog (S. Cerevisiae) 2
  • Polyribonucleotide 5'-Hydroxyl-Kinase 2
  • Homolog Of Yeast CFIA Subunit Clp1p 3
  • ATP/GTP-Binding Protein 3
  • ATP/GTPbinding Protein 2
  • HClp1 3

External Ids for CLP1 Gene

Previous GeneCards Identifiers for CLP1 Gene

  • GC11P057182
  • GC11P057425
  • GC11P053774

Summaries for CLP1 Gene

Entrez Gene Summary for CLP1 Gene

  • This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CLP1 Gene

CLP1 (Cleavage And Polyadenylation Factor I Subunit 1) is a Protein Coding gene. Diseases associated with CLP1 include Pontocerebellar Hypoplasia, Type 10 and Pontocerebellar Hypoplasia. Among its related pathways are Cleavage of Growing Transcript in the Termination Region and tRNA processing. Gene Ontology (GO) annotations related to this gene include ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity and ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity. An important paralog of this gene is NOL9.

UniProtKB/Swiss-Prot Summary for CLP1 Gene

  • Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

Additional gene information for CLP1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLP1 Gene

Genomics for CLP1 Gene

GeneHancer (GH) Regulatory Elements for CLP1 Gene

Promoters and enhancers for CLP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLP1 gene promoter:
  • AREB6
  • Arnt
  • C/EBPbeta
  • CREB
  • deltaCREB
  • GCNF
  • GCNF-1
  • GCNF-2
  • IRF-2
  • NRF-2

Genomic Locations for CLP1 Gene

Genomic Locations for CLP1 Gene
chr11:57,648,992-57,661,865
(GRCh38/hg38)
Size:
12,874 bases
Orientation:
Plus strand
chr11:57,416,465-57,429,340
(GRCh37/hg19)
Size:
12,876 bases
Orientation:
Plus strand

Genomic View for CLP1 Gene

Genes around CLP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLP1 Gene

Proteins for CLP1 Gene

  • Protein details for CLP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92989-CLP1_HUMAN
    Recommended name:
    Polyribonucleotide 5'-hydroxyl-kinase Clp1
    Protein Accession:
    Q92989
    Secondary Accessions:
    • B2R7J6
    • B4DTI8

    Protein attributes for CLP1 Gene

    Size:
    425 amino acids
    Molecular mass:
    47646 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
    Quaternary structure:
    • Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54 (PubMed:24766809). Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.

    Alternative splice isoforms for CLP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLP1 Gene

Selected DME Specific Peptides for CLP1 Gene

Q92989:
  • CRLLLNYAVR
  • NRRASVSGC
  • IPDSCLPLGMSQEDNQLKLVPVTPGRDM
  • QAPLVYHFGSTTPGTNIKLYNK
  • FGTELTRNKKFTFDAGAKVAVFTWHGC
  • RIREYFYGFRGCFYPHAF
  • INTCGWVKGSGYQAL
  • VELDVGQGSVS
  • HAASAFEVDVV
  • LSPAPRPLPK
  • ERPADVEEGFS
  • KFELERETELRFEVEASQ
  • SETSVAGFIVVT
  • RDLPHFVRT

Post-translational modifications for CLP1 Gene

  • Ubiquitination at Lys127
  • Modification sites at PhosphoSitePlus

Other Protein References for CLP1 Gene

Domains & Families for CLP1 Gene

Gene Families for CLP1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CLP1 Gene

Suggested Antigen Peptide Sequences for CLP1 Gene

GenScript: Design optimal peptide antigens:
  • Pre-mRNA cleavage complex II protein Clp1 (CLP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92989

UniProtKB/Swiss-Prot:

CLP1_HUMAN :
  • Belongs to the Clp1 family. Clp1 subfamily.
Family:
  • Belongs to the Clp1 family. Clp1 subfamily.
genes like me logo Genes that share domains with CLP1: view

Function for CLP1 Gene

Molecular function for CLP1 Gene

UniProtKB/Swiss-Prot Function:
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=5'-dephospho-(DNA) + ATP = ADP + H(+) + phospho-5'-(DNA); Xref=Rhea:RHEA:15669, Rhea:RHEA-COMP:13180, Rhea:RHEA-COMP:13184, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:136412, ChEBI:CHEBI:136416, ChEBI:CHEBI:456216; EC=2.7.1.78; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=5'-dephospho-(RNA) + ATP = 5'-end-(RNA) + ADP + H(+); Xref=Rhea:RHEA:54580, Rhea:RHEA-COMP:13935, Rhea:RHEA-COMP:13936, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:138282, ChEBI:CHEBI:138284, ChEBI:CHEBI:456216; EC=2.7.1.78; Evidence=. ;.

Enzyme Numbers (IUBMB) for CLP1 Gene

Phenotypes From GWAS Catalog for CLP1 Gene

Gene Ontology (GO) - Molecular Function for CLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding TAS 8896421
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IEA --
GO:0051733 polydeoxyribonucleotide kinase activity IEA,IDA 17495927
genes like me logo Genes that share ontologies with CLP1: view
genes like me logo Genes that share phenotypes with CLP1: view

Human Phenotype Ontology for CLP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CLP1 Gene

MGI Knock Outs for CLP1:
  • Clp1 Clp1<tm2.2Pngr>

Animal Model Products

CRISPR Products

miRNA for CLP1 Gene

miRTarBase miRNAs that target CLP1

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for CLP1 Gene

Localization for CLP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLP1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
plasma membrane 0
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000214 tRNA-intron endonuclease complex IDA,IEA 17495927
GO:0005634 nucleus IDA,IBA 24766810
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0005849 mRNA cleavage factor complex IEA --
genes like me logo Genes that share ontologies with CLP1: view

Pathways & Interactions for CLP1 Gene

genes like me logo Genes that share pathways with CLP1: view

Pathways by source for CLP1 Gene

Gene Ontology (GO) - Biological Process for CLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IBA 21873635
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS,IBA --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with CLP1: view

No data available for SIGNOR curated interactions for CLP1 Gene

Drugs & Compounds for CLP1 Gene

No Compound Related Data Available

Transcripts for CLP1 Gene

mRNA/cDNA for CLP1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b
SP1:
SP2: - -
SP3: -

Relevant External Links for CLP1 Gene

GeneLoc Exon Structure for
CLP1
ECgene alternative splicing isoforms for
CLP1

Expression for CLP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLP1 Gene

This gene is overexpressed in Stomach (9.7), CD8 Tcells (9.6), Monocytes (8.7), Adrenal (8.5), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CLP1 Gene



Protein tissue co-expression partners for CLP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLP1 Gene:

CLP1

SOURCE GeneReport for Unigene cluster for CLP1 Gene:

Hs.523687

Evidence on tissue expression from TISSUES for CLP1 Gene

  • Lung(4.2)
  • Nervous system(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CLP1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • eyelid
  • face
  • forehead
  • head
  • lip
  • mouth
  • nose
  • skull
Pelvis:
  • testicle
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with CLP1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLP1 Gene

Orthologs for CLP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLP1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 97 (a)
OneToMany
-- 33
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CLP1 33 32
  • 93.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clp1 32
  • 90.67 (n)
mouse
(Mus musculus)
Mammalia Clp1 17 33 32
  • 90.04 (n)
cow
(Bos Taurus)
Mammalia CLP1 33 32
  • 89.49 (n)
OneToOne
chicken
(Gallus gallus)
Aves CLP1 33 32
  • 79.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLP1 33
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clp1 32
  • 68.92 (n)
zebrafish
(Danio rerio)
Actinopterygii CR855307.1 33
  • 76 (a)
OneToOne
LOC565621 32
  • 71.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta CLP1_ANOGA 32
  • 59.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta cbc 33 32
  • 58.76 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clpf-1 33 32
  • 51.34 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLP1 35 33
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CLPS3 32
  • 48.77 (n)
rice
(Oryza sativa)
Liliopsida Os02g0217500 32
  • 48.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 63 (a)
OneToOne
Cin.15542 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15542 32
Species where no ortholog for CLP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLP1 Gene

ENSEMBL:
Gene Tree for CLP1 (if available)
TreeFam:
Gene Tree for CLP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLP1: view image

Paralogs for CLP1 Gene

Paralogs for CLP1 Gene

genes like me logo Genes that share paralogs with CLP1: view

Variants for CLP1 Gene

Sequence variations from dbSNP and Humsavar for CLP1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1555002798 uncertain-significance, Inborn genetic diseases 57,660,909(+) G/A coding_sequence_variant, missense_variant
rs587777616 likely-pathogenic, Pontocerebellar hypoplasia, type 10, not provided, Pontocerebellar hypoplasia 10 (PCH10) [MIM:615803] 57,659,895(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs142476927 likely-benign, not specified 57,660,028(+) G/C coding_sequence_variant, intron_variant, synonymous_variant
rs147951568 likely-benign, not specified 57,660,808(+) T/C coding_sequence_variant, missense_variant
rs1555002441 likely-benign, not specified 57,657,849(+) C/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CLP1 Gene

Variant ID Type Subtype PubMed ID
nsv508633 CNV deletion 20534489
nsv832163 CNV gain 17160897
nsv832164 CNV loss 17160897

Variation tolerance for CLP1 Gene

Residual Variation Intolerance Score: 15.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLP1 Gene

Human Gene Mutation Database (HGMD)
CLP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLP1 Gene

Disorders for CLP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CLP1 Gene - From: HGMD, OMIM, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pontocerebellar hypoplasia, type 10
  • pch10
pontocerebellar hypoplasia
  • pch
- elite association - COSMIC cancer census association via MalaCards
Search CLP1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CLP1_HUMAN
  • Pontocerebellar hypoplasia 10 (PCH10) [MIM:615803]: A form of pontocerebellar hypoplasia, a disorder characterized by structural defects of the pons and cerebellum, evident upon brain imaging. PCH10 features include cortical dysgenesis marked by a simplified gyral pattern, cortical atrophy, mild or focal cerebellar vermian volume loss, delayed myelination, progressive microcephaly, global growth and developmental delays, severe intellectual disabilities, and seizures refractory to treatment. {ECO:0000269 PubMed:24766809, ECO:0000269 PubMed:24766810}. Note=The disease is caused by mutations affecting the gene represented in this entry. Neurodegeneration is due to defects in tRNA splicing (PubMed:24766809, PubMed:24766810). {ECO:0000269 PubMed:24766809, ECO:0000269 PubMed:24766810}.

Additional Disease Information for CLP1

genes like me logo Genes that share disorders with CLP1: view

No data available for Genatlas for CLP1 Gene

Publications for CLP1 Gene

  1. Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo. (PMID: 18648070) Ramirez A … Schwer B (RNA (New York, N.Y.) 2008) 3 4 23 56
  2. The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs. (PMID: 17495927) Weitzer S … Martinez J (Nature 2007) 3 4 23 56
  3. Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. (PMID: 11060040) de Vries H … Keller W (The EMBO journal 2000) 2 3 4 56
  4. AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12). (PMID: 8896421) Tanabe S … Rowley JD (Blood 1996) 2 3 4 56
  5. Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function. (PMID: 24766809) Karaca E … Lupski JR (Cell 2014) 3 4 56

Products for CLP1 Gene

Sources for CLP1 Gene