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Aliases for CLP1 Gene

Aliases for CLP1 Gene

  • Cleavage And Polyadenylation Factor I Subunit 1 2 3 5
  • Pre-MRNA Cleavage Complex II Protein Clp1 3 4
  • Polyadenylation Factor Clp1 3 4
  • Polynucleotide Kinase Clp1 3 4
  • EC 2.7.1.78 4 56
  • HEAB 3 4
  • CLP1, Cleavage And Polyadenylation Factor I Subunit, Homolog (S. Cerevisiae) 2
  • Polyribonucleotide 5-Hydroxyl-Kinase Clp1 3
  • Polyribonucleotide 5-Hydroxyl-Kinase 2
  • Homolog Of Yeast CFIA Subunit Clp1p 3
  • ATP/GTP-Binding Protein 3
  • ATP/GTPbinding Protein 2
  • HClp1 3

External Ids for CLP1 Gene

Previous GeneCards Identifiers for CLP1 Gene

  • GC11P057182
  • GC11P057425
  • GC11P053774

Summaries for CLP1 Gene

Entrez Gene Summary for CLP1 Gene

  • This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CLP1 Gene

CLP1 (Cleavage And Polyadenylation Factor I Subunit 1) is a Protein Coding gene. Diseases associated with CLP1 include Pontocerebellar Hypoplasia, Type 10 and Anus Disease. Among its related pathways are mRNA Splicing - Major Pathway and RNA Polymerase II Transcription Termination. Gene Ontology (GO) annotations related to this gene include ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activity and ATP-dependent polyribonucleotide 5-hydroxyl-kinase activity.

UniProtKB/Swiss-Prot for CLP1 Gene

  • Polynucleotide kinase that can phosphorylate the 5-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5-terminus of the tRNA 3-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3-end formation. Also phosphorylates the 5-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

Additional gene information for CLP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLP1 Gene

Genomics for CLP1 Gene

GeneHancer (GH) Regulatory Elements for CLP1 Gene

Promoters and enhancers for CLP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I057644 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.5 -1545 6.6 HDGF SMAD1 ARNT ARID4B SIN3A YBX1 ZNF766 ZNF143 FOS PAF1 CLP1 YPEL4 TIMM10 MED19 SSRP1 PPIAP42 ENSG00000269570 ENSG00000254602 MIR130A
GH11I057656 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 581.3 +8.6 8645 2 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 ZNF766 E2F8 CLP1 ENSG00000269570 ZDHHC5 SSRP1 ENSG00000255299 MED19 YPEL4
GH11I057334 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 25.6 -313.4 -313397 2.7 ATF1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 E2F8 SSRP1 P2RX3 CLP1 ZDHHC5 TNKS1BP1 LRRC55 ENSG00000254662
GH11I057529 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.9 -118.3 -118303 2.5 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 PIR40820 TIMM10 PIR39300 SSRP1 CLP1 MIR130A UBE2L6 RPS4XP13 ENSG00000254602 YPEL4
GH11I058572 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.5 +928.5 928494 9.5 CLOCK DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF263 SP3 NFYC PPARGC1A LPXN ZFP91 ZFP91-CNTF ENSG00000269570 ENSG00000255008 OR5B21 CLP1 ENSG00000197254 CTNND1 ZDHHC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLP1 gene promoter:

Genomic Locations for CLP1 Gene

Genomic Locations for CLP1 Gene
chr11:57,648,992-57,661,868
(GRCh38/hg38)
Size:
12,877 bases
Orientation:
Plus strand
chr11:57,416,465-57,429,340
(GRCh37/hg19)

Genomic View for CLP1 Gene

Genes around CLP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLP1 Gene

Proteins for CLP1 Gene

  • Protein details for CLP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92989-CLP1_HUMAN
    Recommended name:
    Polyribonucleotide 5-hydroxyl-kinase Clp1
    Protein Accession:
    Q92989
    Secondary Accessions:
    • B2R7J6
    • B4DTI8

    Protein attributes for CLP1 Gene

    Size:
    425 amino acids
    Molecular mass:
    47646 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
    Quaternary structure:
    • Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54 (PubMed:24766809). Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.

    Alternative splice isoforms for CLP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLP1 Gene

Selected DME Specific Peptides for CLP1 Gene

Q92989:
  • CRLLLNYAVR
  • NRRASVSGC
  • IPDSCLPLGMSQEDNQLKLVPVTPGRDM
  • QAPLVYHFGSTTPGTNIKLYNK
  • FGTELTRNKKFTFDAGAKVAVFTWHGC
  • RIREYFYGFRGCFYPHAF
  • INTCGWVKGSGYQAL
  • VELDVGQGSVS
  • HAASAFEVDVV
  • LSPAPRPLPK
  • ERPADVEEGFS
  • KFELERETELRFEVEASQ
  • SETSVAGFIVVT
  • RDLPHFVRT

Post-translational modifications for CLP1 Gene

  • Ubiquitination at Lys127
  • Modification sites at PhosphoSitePlus

Other Protein References for CLP1 Gene

Domains & Families for CLP1 Gene

Gene Families for CLP1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CLP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92989

UniProtKB/Swiss-Prot:

CLP1_HUMAN :
  • Belongs to the Clp1 family. Clp1 subfamily.
Family:
  • Belongs to the Clp1 family. Clp1 subfamily.
genes like me logo Genes that share domains with CLP1: view

Function for CLP1 Gene

Molecular function for CLP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 5-dephospho-DNA = ADP + 5-phospho-DNA.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 5-dephospho-RNA = ADP + 5-phospho-RNA.
UniProtKB/Swiss-Prot Function:
Polynucleotide kinase that can phosphorylate the 5-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5-terminus of the tRNA 3-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3-end formation. Also phosphorylates the 5-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

Enzyme Numbers (IUBMB) for CLP1 Gene

Phenotypes From GWAS Catalog for CLP1 Gene

Gene Ontology (GO) - Molecular Function for CLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding TAS 8896421
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046404 ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activity IEA --
GO:0051733 polydeoxyribonucleotide kinase activity IDA 17495927
genes like me logo Genes that share ontologies with CLP1: view
genes like me logo Genes that share phenotypes with CLP1: view

Human Phenotype Ontology for CLP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CLP1 Gene

MGI Knock Outs for CLP1:

Animal Model Products

miRNA for CLP1 Gene

miRTarBase miRNAs that target CLP1

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for CLP1 Gene

Localization for CLP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLP1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000214 tRNA-intron endonuclease complex IDA 17495927
GO:0005634 nucleus IEA,IDA 24766810
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0005849 mRNA cleavage factor complex IEA --
genes like me logo Genes that share ontologies with CLP1: view

Pathways & Interactions for CLP1 Gene

genes like me logo Genes that share pathways with CLP1: view

Pathways by source for CLP1 Gene

Gene Ontology (GO) - Biological Process for CLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IBA --
GO:0006379 mRNA cleavage IBA --
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS --
genes like me logo Genes that share ontologies with CLP1: view

No data available for SIGNOR curated interactions for CLP1 Gene

Drugs & Compounds for CLP1 Gene

No Compound Related Data Available

Transcripts for CLP1 Gene

Unigene Clusters for CLP1 Gene

Cleavage and polyadenylation factor I subunit 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b
SP1:
SP2: - -
SP3: -

Relevant External Links for CLP1 Gene

GeneLoc Exon Structure for
CLP1
ECgene alternative splicing isoforms for
CLP1

Expression for CLP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLP1 Gene

This gene is overexpressed in Stomach (9.7), CD8 Tcells (9.6), Monocytes (8.7), Adrenal (8.5), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLP1 Gene



Protein tissue co-expression partners for CLP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLP1 Gene:

CLP1

SOURCE GeneReport for Unigene cluster for CLP1 Gene:

Hs.523687

Evidence on tissue expression from TISSUES for CLP1 Gene

  • Lung(4.2)
  • Nervous system(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CLP1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • eyelid
  • face
  • forehead
  • head
  • lip
  • mouth
  • nose
  • skull
Pelvis:
  • testicle
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with CLP1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLP1 Gene

Orthologs for CLP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLP1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 97 (a)
OneToMany
-- 34
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CLP1 33 34
  • 93.73 (n)
rat
(Rattus norvegicus)
Mammalia Clp1 33
  • 90.67 (n)
mouse
(Mus musculus)
Mammalia Clp1 33 16 34
  • 90.04 (n)
cow
(Bos Taurus)
Mammalia CLP1 33 34
  • 89.49 (n)
chicken
(Gallus gallus)
Aves CLP1 33 34
  • 79.69 (n)
lizard
(Anolis carolinensis)
Reptilia CLP1 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clp1 33
  • 68.92 (n)
zebrafish
(Danio rerio)
Actinopterygii CR855307.1 34
  • 76 (a)
OneToOne
LOC565621 33
  • 71.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta CLP1_ANOGA 33
  • 59.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta cbc 33 34
  • 58.76 (n)
worm
(Caenorhabditis elegans)
Secernentea clpf-1 33 34
  • 51.34 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLP1 34 36
  • 24 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons CLPS3 33
  • 48.77 (n)
rice
(Oryza sativa)
Liliopsida Os02g0217500 33
  • 48.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 63 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15542 33
Species where no ortholog for CLP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLP1 Gene

ENSEMBL:
Gene Tree for CLP1 (if available)
TreeFam:
Gene Tree for CLP1 (if available)

Paralogs for CLP1 Gene

No data available for Paralogs for CLP1 Gene

Variants for CLP1 Gene

Sequence variations from dbSNP and Humsavar for CLP1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs587777616 conflicting-interpretations-of-pathogenicity, Pontocerebellar hypoplasia, type 10, Pontocerebellar hypoplasia 10 (PCH10) [MIM:615803] 57,659,895(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs142476927 likely-benign, not specified 57,660,028(+) G/C coding_sequence_variant, intron_variant, synonymous_variant
rs150146614 uncertain-significance, not specified 57,661,056(+) C/T coding_sequence_variant, missense_variant
rs370085533 uncertain-significance, not specified 57,660,802(+) G/A coding_sequence_variant, missense_variant
rs746040503 uncertain-significance, not specified 57,661,020(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CLP1 Gene

Variant ID Type Subtype PubMed ID
nsv508633 CNV deletion 20534489
nsv832163 CNV gain 17160897
nsv832164 CNV loss 17160897

Variation tolerance for CLP1 Gene

Residual Variation Intolerance Score: 15.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLP1 Gene

Human Gene Mutation Database (HGMD)
CLP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLP1 Gene

Disorders for CLP1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CLP1 Gene - From: HGMD, OMIM, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pontocerebellar hypoplasia, type 10
  • pch10
anus disease
  • anal disease
pontocerebellar hypoplasia
  • pch
rectal disease
  • rectal disorders
- elite association - COSMIC cancer census association via MalaCards
Search CLP1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CLP1_HUMAN
  • Pontocerebellar hypoplasia 10 (PCH10) [MIM:615803]: A form of pontocerebellar hypoplasia, a disorder characterized by structural defects of the pons and cerebellum, evident upon brain imaging. PCH10 features include cortical dysgenesis marked by a simplified gyral pattern, cortical atrophy, mild or focal cerebellar vermian volume loss, delayed myelination, progressive microcephaly, global growth and developmental delays, severe intellectual disabilities, and seizures refractory to treatment. {ECO:0000269 PubMed:24766809, ECO:0000269 PubMed:24766810}. Note=The disease is caused by mutations affecting the gene represented in this entry. Neurodegeneration is due to defects in tRNA splicing (PubMed:24766809, PubMed:24766810). {ECO:0000269 PubMed:24766809, ECO:0000269 PubMed:24766810}.

Additional Disease Information for CLP1

genes like me logo Genes that share disorders with CLP1: view

No data available for Genatlas for CLP1 Gene

Publications for CLP1 Gene

  1. Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo. (PMID: 18648070) Ramirez A … Schwer B (RNA (New York, N.Y.) 2008) 3 4 22 58
  2. The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs. (PMID: 17495927) Weitzer S … Martinez J (Nature 2007) 3 4 22 58
  3. Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. (PMID: 11060040) de Vries H … Keller W (The EMBO journal 2000) 2 3 4 58
  4. AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12). (PMID: 8896421) Tanabe S … Rowley JD (Blood 1996) 2 3 4 58
  5. Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function. (PMID: 24766809) Karaca E … Lupski JR (Cell 2014) 3 4 58

Products for CLP1 Gene

Sources for CLP1 Gene

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