Aliases for CLNK Gene
Aliases for CLNK Gene
External Ids for CLNK Gene
- HGNC: 17438
- Entrez Gene: 116449
- Ensembl: ENSG00000109684
- OMIM: 611434
- UniProtKB: Q7Z7G1
Previous GeneCards Identifiers for CLNK Gene
- GC04M010100
- GC04M009825
Summaries for CLNK Gene
-
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CLNK Gene
CLNK (Cytokine Dependent Hematopoietic Cell Linker) is a Protein Coding gene. Diseases associated with CLNK include Croup and Trichotillomania. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is LCP2.
UniProtKB/Swiss-Prot for CLNK Gene
-
Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity).
Additional gene information for CLNK Gene
- Monarch Initiative
- Search for CLNK at DataMed
- Search for CLNK at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLNK Gene
Genomics for CLNK Gene
GeneHancer (GH) Regulatory Elements for CLNK Gene
Promoters and enhancers for CLNK Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J010683 | Promoter/Enhancer | 1.1 | EPDnew ENCODE | 650.2 | +50.4 | 50355 | 1.6 | ZNF687 SMAD5 NR2F1 ELF1 ATF2 RELA POLR2A BCL11A IKZF1 MLLT1 | ENSG00000249334 CLNK LOC105374480 | |
| GH04J010734 | Promoter | 0.7 | EPDnew | 650.7 | 0.0 | -7 | 0.1 | RFX1 IKZF1 IKZF2 | CLNK LINC02498 | |
| GH04J010668 | Promoter | 0.5 | EPDnew | 650.2 | +65.9 | 65931 | 0.1 | CLNK ENSG00000249334 LOC105374480 | ||
| GH04J010611 | Enhancer | 0.8 | Ensembl ENCODE | 11.8 | +123.0 | 122958 | 1.4 | ZNF639 ZNF280D ZNF189 JUN GFI1B ZEB2 ZEB1 JUND ZNF366 ZBTB48 | ENSG00000249334 CLNK HS3ST1 LOC105374480 LOC105374481 | |
| GH04J010640 | Enhancer | 0.6 | Ensembl ENCODE | 11.7 | +94.0 | 93953 | 1 | MAX EBF1 ETV6 | ENSG00000249334 CLNK LOC105374480 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CLNK on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CLNK gene promoter:
Regulatory Element Products
Genomic Locations for CLNK Gene
Genomic Locations for CLNK Gene
- chr4:10,486,395-10,734,853
- (GRCh38/hg38)
- Size:
- 248,459 bases
- Orientation:
- Minus strand
- chr4:10,488,019-10,686,489
- (GRCh37/hg19)
Genomic View for CLNK Gene
Genes around CLNK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.1 by Entrez Gene
- 4p16.1 by HGNC
- 4p16.1 by Ensembl
CLNK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLNK Gene
Proteins for CLNK Gene
-
Protein details for CLNK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z7G1-CLNK_HUMAN
- Recommended name:
- Cytokine-dependent hematopoietic cell linker
- Protein Accession:
- Q7Z7G1
- Q05C27
- Q9P2U9
Protein attributes for CLNK Gene
- Size:
- 428 amino acids
- Molecular mass:
- 49554 Da
- Quaternary structure:
-
- When phosphorylated, interacts with PLCG1, PLCG2, GRB2, VAV and LAT.
Protein Expression for CLNK Gene
Post-translational modifications for CLNK Gene
- Tyrosine-phosphorylated upon BCR cross-linking. Tyrosine phosphorylation at both Tyr-69 and Tyr-96 are required for BCR-induced calcium response and are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40 cells, but this phosphorylation is dispensable in cells expressing LAT. Interacts with the SH2 domain of PLCG1 via phosphorylated Tyr-96 (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CLNK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CLNK
- Novus Biologicals Antibodies for CLNK
- Invitrogen Antibodies for CLNK
- Search GeneTex for Antibodies for CLNK
-
Boster Bio Antibodies for CLNK
Protein Products
-
OriGene Purified Proteins for CLNK
- Search Origene for MassSpec and Protein Over-expression Lysates for CLNK
- Origene Custom Protein Services for CLNK
- antibodies-online: Search results for 4 available CLNK Proteins ranked by validation data
- Compare Top CLNK Proteins
-
Quality Products:
- Search GeneTex for Proteins for CLNK
Assay Products
- antibodies-online: Search results for available CLNK related products ranked by validation data
No data available for DME Specific Peptides for CLNK Gene
Domains & Families for CLNK Gene
Gene Families for CLNK Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CLNK Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CLNK Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z7G1UniProtKB/Swiss-Prot:
CLNK_HUMAN :- The N-terminal proline-rich region interacts with the SH3 domain of PLCG1.
- Domain:
-
- The N-terminal proline-rich region interacts with the SH3 domain of PLCG1.
- The SH2 domain is important for restoration of BCR-induced calcium response and JNK2 activation in BLNK-deficient DT40 cells expressing LAT.
Function for CLNK Gene
Molecular function for CLNK Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity).
Phenotypes From GWAS Catalog for CLNK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | NAS | 10744659 |
| GO:0005515 | protein binding | IPI | 16273093 |
Phenotypes for CLNK Gene
- MGI mutant phenotypes for CLNK:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CLNK:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased viability
- no effect
- Mildly decreased CFP-tsO45G cell surface transport
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Model Products
-
Taconic Biosciences Mouse Models for CLNK
- Cyagen custom Knockout/knockin (KOKI) mouse models for CLNK
-
CRISPR Products
-
OriGene CRISPR knockouts for CLNK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLNK
- genomics-online: gRNA clones - Search results for available CLNK gene related products
- Applied Biological Materials CRISPR for CLNK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLNK
- GenScript: Design CRISPR guide RNA sequences for CLNK
miRNA for CLNK Gene
- miRTarBase miRNAs that target CLNK
-
- hsa-mir-4659b-3p (MIRT621375)
- hsa-mir-4659a-3p (MIRT621376)
- hsa-mir-6875-3p (MIRT621377)
- hsa-mir-4652-3p (MIRT621378)
- hsa-mir-629-3p (MIRT621379)
- hsa-mir-6867-3p (MIRT621380)
- hsa-mir-4713-5p (MIRT621381)
- hsa-mir-211-5p (MIRT621382)
- hsa-mir-204-5p (MIRT621383)
- hsa-mir-3682-5p (MIRT621384)
- hsa-mir-3182 (MIRT621385)
- hsa-mir-942-5p (MIRT621386)
- hsa-mir-4685-3p (MIRT621387)
- hsa-mir-4287 (MIRT621388)
- hsa-mir-7113-3p (MIRT621389)
- hsa-mir-4469 (MIRT621390)
- hsa-mir-6832-3p (MIRT621391)
- hsa-mir-6768-5p (MIRT650688)
- hsa-mir-8485 (MIRT650689)
- hsa-mir-548x-3p (MIRT650690)
- hsa-mir-548j-3p (MIRT650691)
- hsa-mir-548aq-3p (MIRT650692)
- hsa-mir-548am-3p (MIRT650693)
- hsa-mir-548aj-3p (MIRT650694)
- hsa-mir-548ah-3p (MIRT650695)
- hsa-mir-548ae-3p (MIRT650696)
- hsa-mir-548z (MIRT650697)
- hsa-mir-548h-3p (MIRT650698)
- hsa-mir-548d-3p (MIRT650699)
- hsa-mir-548bb-3p (MIRT650700)
- hsa-mir-548ac (MIRT650701)
- hsa-mir-1228-3p (MIRT761422)
- hsa-mir-1976 (MIRT763550)
- hsa-mir-3653-5p (MIRT766346)
- hsa-mir-377-3p (MIRT767345)
- hsa-mir-4279 (MIRT768296)
- hsa-mir-4722-3p (MIRT771465)
- hsa-mir-4740-3p (MIRT771855)
- hsa-mir-6727-3p (MIRT777867)
- hsa-mir-6747-3p (MIRT778256)
- hsa-mir-6778-3p (MIRT778797)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLNK
- Browse OriGene Inhibitory RNA Products For CLNK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLNK
- genomics-online: shRNA clones - Search results for available CLNK gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CLNK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CLNK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLNK
- genomics-online: cdna clones - Search results for available CLNK gene related products
- orf clones - Search results for available CLNK gene related products
- Applied Biological Materials Clones for CLNK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CLNK
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLNK Gene
Localization for CLNK Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | NAS | 10744659 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CLNK Gene
Pathways & Interactions for CLNK Gene
No Data Available
Interacting Proteins for CLNK Gene
Selected Interacting proteins:
Q7Z7G1-CLNK_HUMAN
ENSP00000226951
for CLNK Gene via
IID
MINT
STRING
UniProtKB
GPS-Prot Interaction Network for CLNK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | IBA,NAS | 10744659 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | -- |
| GO:0009967 | positive regulation of signal transduction | IEA | -- |
| GO:0035556 | intracellular signal transduction | IDA | 10744659 |
No data available for Pathways by source and SIGNOR curated interactions for CLNK Gene
Transcripts for CLNK Gene
mRNA/cDNA for CLNK Gene
- (8) Selected AceView cDNA sequences:
- (6) Additional mRNA sequences :
- (4) REFSEQ mRNAs :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000226951 5599 bps (uc003gmo.5)
- ENST00000442825 1539 bps (uc062vep.1)
- ENST00000507719 1143 bps (uc003gmp.4)
- ENST00000515667 4180 bps (uc062veo.1)
Unigene Clusters for CLNK Gene
CRISPR Products
-
OriGene CRISPR knockouts for CLNK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLNK
- genomics-online: gRNA clones - Search results for available CLNK gene related products
- Applied Biological Materials CRISPR for CLNK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLNK
- GenScript: Design CRISPR guide RNA sequences for CLNK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLNK
- Browse OriGene Inhibitory RNA Products For CLNK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLNK
- genomics-online: shRNA clones - Search results for available CLNK gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CLNK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CLNK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLNK
- genomics-online: cdna clones - Search results for available CLNK gene related products
- orf clones - Search results for available CLNK gene related products
- Applied Biological Materials Clones for CLNK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CLNK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Conventional Dendritic Cells I Spleen
- Hematopoietic Bone Marrow
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
- Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CLNK Gene
This gene is overexpressed in Kidney - Cortex (x12.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLNK Gene
NURSA nuclear receptor signaling pathways regulating expression of CLNK Gene:
CLNKSOURCE GeneReport for Unigene cluster for CLNK Gene:
Hs.678910Evidence on tissue expression from TISSUES for CLNK Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for CLNK
- genomics-online: primer clones - Search results for available CLNK gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLNK Gene
Orthologs for CLNK Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CLNK 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CLNK 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CLNK 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Clnk 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Clnk 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CLNK 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | SLP76 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | CLNK 34 |
|
OneToOne |
- Species where no ortholog for CLNK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CLNK Gene
- ENSEMBL:
- Gene Tree for CLNK (if available)
- TreeFam:
- Gene Tree for CLNK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CLNK: view image
Paralogs for CLNK Gene
Variants for CLNK Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2903960 | benign, not specified | 10,501,313(-) | T/A/G | coding_sequence_variant, synonymous_variant | |
| rs61759824 | benign, not specified | 10,584,947(-) | G/A | coding_sequence_variant, missense_variant | |
| rs1000002809 | -- | 10,717,433(-) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs10000059 | -- | 10,720,715(-) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000006086 | -- | 10,640,516(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.55;
55.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLNK Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLNK Gene
Disorders for CLNK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| croup |
|
|
| trichotillomania |
|
|
| stereotypic movement disorder |
|
|
| impulse control disorder |
|
|
| gingival recession |
|
|
Search CLNK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CLNK
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CLNK Gene
Publications for CLNK Gene
- A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation. (PMID: 10744659) Goitsuka R … Kitamura D (International immunology 2000) 2 3 4 58
- Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells. (PMID: 10562326) Cao MY … Veillette A (The Journal of experimental medicine 1999) 2 3 58
- WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients. (PMID: 26438387) Lan B … Kang L (Rheumatology international 2016) 3 58
- Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
- Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets. (PMID: 25591661) Jin TB … Kang L (Rheumatology international 2015) 3 58
Products for CLNK Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CLNK
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CLNK
- Search Origene for MassSpec and Protein Over-expression Lysates for CLNK
- Origene Custom Protein Services for CLNK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLNK
- Browse OriGene Inhibitory RNA Products For CLNK
- OriGene qPCR primer pairs for CLNK
- OriGene CRISPR knockouts for CLNK
- OriGene ORF clones in human for CLNK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CLNK
- GenScript: Next-day shipping of latest version cDNA ORF clones for CLNK in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CLNK
- GenScript Custom Assay Services for CLNK
- GenScript Custom overexpressing Cell Line Services for CLNK
- GenScript: Design CRISPR guide RNA sequences for CLNK
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CLNK
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CLNK
- Novus Biologicals proteins and lysates for CLNK
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for CLNK
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- VectorBuilder custom plasmid, inducible vectors for CLNK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CLNK
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 23 available CLNK Antibodies ranked by validation data
- Compare Top CLNK Antibodies
- antibodies-online: Search results for available CLNK related products ranked by validation data
- antibodies-online: Search results for 4 available CLNK Proteins ranked by validation data
- Compare Top CLNK Proteins
- Quality Products:
- Search GeneTex for Antibodies for CLNK
- Search GeneTex for Proteins for CLNK
- Horizon Cell Lines for CLNK
- genomics-online: cdna clones - Search results for available CLNK gene related products
- orf clones - Search results for available CLNK gene related products
- genomics-online: gRNA clones - Search results for available CLNK gene related products
- genomics-online: primer clones - Search results for available CLNK gene related products
- genomics-online: shRNA clones - Search results for available CLNK gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLNK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLNK
- GeneCopoeia miRNA 3'UTR Target clone products for CLNK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLNK
- Boster Bio Antibodies for CLNK
- Browse Boster Bio ELISA Kits
Sources for CLNK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio