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Aliases for CLNK Gene

Aliases for CLNK Gene

  • Cytokine Dependent Hematopoietic Cell Linker 2 3 5
  • Mast Cell Immunoreceptor Signal Transducer 2 3 4
  • Cytokine-Dependent Hematopoietic Cell Linker 3 4
  • MIST 3 4

External Ids for CLNK Gene

Previous GeneCards Identifiers for CLNK Gene

  • GC04M010100
  • GC04M009825

Summaries for CLNK Gene

Entrez Gene Summary for CLNK Gene

  • MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CLNK Gene

CLNK (Cytokine Dependent Hematopoietic Cell Linker) is a Protein Coding gene. Diseases associated with CLNK include Croup and Stereotypic Movement Disorder. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is LCP2.

UniProtKB/Swiss-Prot for CLNK Gene

  • Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity).

Additional gene information for CLNK Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLNK Gene

Genomics for CLNK Gene

GeneHancer (GH) Regulatory Elements for CLNK Gene

Promoters and enhancers for CLNK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J010683 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 600.2 +50.4 50355 1.6 ZNF687 MLLT1 POLR2A RELA SMAD5 RUNX3 ELF1 BCL11A IKZF1 NR2F1 ENSG00000249334 CLNK LOC105374480
GH04J010734 Promoter 0.7 EPDnew 600.7 0.0 -7 0.1 IKZF1 IKZF2 RFX1 CLNK LINC02498
GH04J010668 Promoter 0.5 EPDnew 600.2 +65.9 65931 0.1 CLNK ENSG00000249334 LOC105374480
GH04J010611 Enhancer 0.9 Ensembl ENCODE 11.8 +123.0 122967 1.4 PRDM1 ZNF600 PRDM10 ZEB2 ZNF639 ZEB1 ZBTB48 FOS ZNF189 ZNF366 ENSG00000249334 CLNK HS3ST1 LOC105374480 LOC105374481
GH04J010640 Enhancer 0.7 Ensembl ENCODE 11.7 +94.4 94352 3 POLR2A EBF1 MAX ETV6 ENSG00000249334 CLNK LOC105374480
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLNK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLNK gene promoter:
  • Evi-1
  • GR
  • GR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SRF (504 AA)

Genomic Locations for CLNK Gene

Genomic Locations for CLNK Gene
248,459 bases
Minus strand
198,471 bases
Minus strand

Genomic View for CLNK Gene

Genes around CLNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLNK Gene

Proteins for CLNK Gene

  • Protein details for CLNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytokine-dependent hematopoietic cell linker
    Protein Accession:
    Secondary Accessions:
    • Q05C27
    • Q9P2U9

    Protein attributes for CLNK Gene

    428 amino acids
    Molecular mass:
    49554 Da
    Quaternary structure:
    • When phosphorylated, interacts with PLCG1, PLCG2, GRB2, VAV and LAT.

    Alternative splice isoforms for CLNK Gene


neXtProt entry for CLNK Gene

Post-translational modifications for CLNK Gene

  • Tyrosine-phosphorylated upon BCR cross-linking. Tyrosine phosphorylation at both Tyr-69 and Tyr-96 are required for BCR-induced calcium response and are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40 cells, but this phosphorylation is dispensable in cells expressing LAT. Interacts with the SH2 domain of PLCG1 via phosphorylated Tyr-96 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLNK Gene

No data available for DME Specific Peptides for CLNK Gene

Domains & Families for CLNK Gene

Gene Families for CLNK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CLNK Gene


Suggested Antigen Peptide Sequences for CLNK Gene

GenScript: Design optimal peptide antigens:
  • Mast cell immunoreceptor signal transducer (CLNK_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The N-terminal proline-rich region interacts with the SH3 domain of PLCG1.
  • The N-terminal proline-rich region interacts with the SH3 domain of PLCG1.
  • The SH2 domain is important for restoration of BCR-induced calcium response and JNK2 activation in BLNK-deficient DT40 cells expressing LAT.
genes like me logo Genes that share domains with CLNK: view

Function for CLNK Gene

Molecular function for CLNK Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity).

Phenotypes From GWAS Catalog for CLNK Gene

Gene Ontology (GO) - Molecular Function for CLNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity NAS 10744659
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with CLNK: view
genes like me logo Genes that share phenotypes with CLNK: view

Animal Models for CLNK Gene

MGI Knock Outs for CLNK:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLNK

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLNK

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLNK Gene

Localization for CLNK Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLNK gene
Compartment Confidence
nucleus 3
mitochondrion 1
cytosol 1
extracellular 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CLNK Gene

Pathways & Interactions for CLNK Gene

PathCards logo

SuperPathways for CLNK Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 10744659
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0009967 positive regulation of signal transduction IEA --
GO:0035556 intracellular signal transduction IDA 10744659
genes like me logo Genes that share ontologies with CLNK: view

No data available for Pathways by source and SIGNOR curated interactions for CLNK Gene

Drugs & Compounds for CLNK Gene

(2) Drugs for CLNK Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7611
Antihypertensives Pharma 0
genes like me logo Genes that share compounds with CLNK: view

Transcripts for CLNK Gene

mRNA/cDNA for CLNK Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for CLNK Gene

Cytokine-dependent hematopoietic cell linker:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLNK

Alternative Splicing Database (ASD) splice patterns (SP) for CLNK Gene

No ASD Table

Relevant External Links for CLNK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLNK Gene

This gene is overexpressed in Kidney - Cortex (x12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLNK Gene

NURSA nuclear receptor signaling pathways regulating expression of CLNK Gene:


SOURCE GeneReport for Unigene cluster for CLNK Gene:


Evidence on tissue expression from TISSUES for CLNK Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CLNK: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLNK Gene

Orthologs for CLNK Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLNK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLNK 35 34
  • 99.22 (n)
(Bos Taurus)
Mammalia CLNK 35 34
  • 81.45 (n)
(Canis familiaris)
Mammalia CLNK 35 34
  • 81.38 (n)
(Rattus norvegicus)
Mammalia Clnk 34
  • 75.53 (n)
(Mus musculus)
Mammalia Clnk 17 35 34
  • 75.26 (n)
(Monodelphis domestica)
Mammalia CLNK 35
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
(Gallus gallus)
Aves SLP76 35
  • 20 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 18 (a)
(Danio rerio)
Actinopterygii CLNK 35
  • 22 (a)
Species where no ortholog for CLNK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLNK Gene

Gene Tree for CLNK (if available)
Gene Tree for CLNK (if available)
Evolutionary constrained regions (ECRs) for CLNK: view image

Paralogs for CLNK Gene

Paralogs for CLNK Gene

(2) SIMAP similar genes for CLNK Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLNK: view

Variants for CLNK Gene

Sequence variations from dbSNP and Humsavar for CLNK Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs2903960 benign, not specified 10,501,313(-) T/A/G coding_sequence_variant, synonymous_variant
rs61759824 benign, not specified 10,584,947(-) G/A coding_sequence_variant, missense_variant
rs1000002809 -- 10,717,433(-) T/G genic_upstream_transcript_variant, intron_variant
rs10000059 -- 10,720,715(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000006086 -- 10,640,516(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLNK Gene

Variant ID Type Subtype PubMed ID
dgv1463e212 CNV loss 25503493
dgv2935e59 CNV tandem duplication 20981092
esv2664970 CNV deletion 23128226
esv2727176 CNV deletion 23290073
esv2727177 CNV deletion 23290073
esv2759223 CNV loss 17122850
esv2797 CNV loss 18987735
esv32732 CNV loss 17666407
esv3306200 CNV mobile element insertion 20981092
esv3341192 CNV insertion 20981092
esv3387645 CNV insertion 20981092
esv3414661 CNV insertion 20981092
esv3563417 CNV deletion 23714750
esv3599624 CNV loss 21293372
esv3599625 CNV loss 21293372
esv3599626 CNV loss 21293372
esv3599627 CNV loss 21293372
esv3599628 CNV loss 21293372
esv3893876 CNV gain 25118596
esv3893877 CNV loss 25118596
nsv1014335 CNV gain 25217958
nsv1116399 CNV insertion 24896259
nsv1117372 CNV tandem duplication 24896259
nsv1132930 CNV insertion 24896259
nsv4234 CNV insertion 18451855
nsv472031 CNV novel sequence insertion 20440878
nsv517971 CNV gain 19592680
nsv518387 CNV loss 19592680
nsv525514 CNV loss 19592680
nsv527914 CNV gain 19592680
nsv593727 CNV gain 21841781
nsv820003 CNV gain 19587683
nsv829858 CNV gain+loss 17160897
nsv829860 CNV gain 17160897

Variation tolerance for CLNK Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLNK Gene

Disorders for CLNK Gene

MalaCards: The human disease database

(9) MalaCards diseases for CLNK Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
  • acute laryngotracheobronchitis
stereotypic movement disorder
  • stereotyped repetitive movements
  • ttm
impulse control disorder
  • disruptive, impulse control, and conduct disorders
gingival recession
  • gingival recession, localized
- elite association - COSMIC cancer census association via MalaCards
Search CLNK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CLNK

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CLNK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLNK Gene

Publications for CLNK Gene

  1. A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation. (PMID: 10744659) Goitsuka R … Kitamura D (International immunology 2000) 2 3 4 58
  2. Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells. (PMID: 10562326) Cao MY … Veillette A (The Journal of experimental medicine 1999) 2 3 58
  3. WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients. (PMID: 26438387) Lan B … Kang L (Rheumatology international 2016) 3 58
  4. Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets. (PMID: 25591661) Jin TB … Kang L (Rheumatology international 2015) 3 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for CLNK Gene

Sources for CLNK Gene

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