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MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]
CLNK (Cytokine Dependent Hematopoietic Cell Linker) is a Protein Coding gene. Diseases associated with CLNK include Tuberculous Empyema and Trichotillomania. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is LCP2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04J010683 | Promoter/Enhancer | 1.1 | EPDnew Ensembl ENCODE | 600.2 | +50.4 | 50355 | 1.6 | POLR2A SMAD5 RELA RUNX3 GATAD2B BCL11A ELF1 IKZF1 NR2F1 SPI1 | ENSG00000249334 CLNK LOC105374480 ZNF518B | |
GH04J010732 | Enhancer | 0.9 | Ensembl ENCODE | 600.7 | +1.9 | 1852 | 1.6 | SP1 LARP7 RELA TCF12 IKZF2 POLR2A TRIM22 PKNOX1 EED ZSCAN29 | CLNK HS3ST1 ENSG00000249334 ZNF518B | |
GH04J010734 | Promoter | 0.7 | EPDnew | 600.7 | 0.0 | -7 | 0.1 | TCF12 IKZF2 RFX1 IKZF1 TBX21 MTA2 BHLHE40 EGR1 RAD51 | CLNK LINC02498 HS3ST1 | |
GH04J010668 | Promoter | 0.3 | EPDnew | 600.2 | +65.9 | 65931 | 0.1 | CLNK ENSG00000249334 LOC105374480 ZNF518B | ||
GH04J010611 | Enhancer | 0.8 | Ensembl ENCODE | 11.8 | +123.0 | 122952 | 1.4 | PRDM10 PRDM1 ZNF600 ZNF639 JUND CEBPB ZEB1 ZBTB48 FOS ZNF189 | ENSG00000249334 CLNK HS3ST1 HSALNG0032894 piR-56133-159 ZNF518B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005070 | SH3/SH2 adaptor activity | NAS | -- |
GO:0005515 | protein binding | IPI | 16273093 |
GO:0044877 | protein-containing complex binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IMP | 26009488 |
GO:0032991 | protein-containing complex | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002729 | positive regulation of natural killer cell cytokine production | IEA | -- |
GO:0006955 | immune response | NAS | 10744659 |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | 21873635 |
GO:0009967 | positive regulation of signal transduction | IEA | -- |
GO:0010941 | regulation of cell death | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CLNK 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CLNK 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CLNK 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Clnk 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Clnk 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CLNK 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | SLP76 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | CLNK 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2903960 | Benign: not specified | 10,501,313(-) | T/G | SYNONYMOUS_VARIANT | |
rs61759824 | Benign: not specified | 10,584,947(-) | G/A | MISSENSE_VARIANT | |
rs16869924 | - | p.Ser65Gly |
Disorder | Aliases | PubMed IDs |
---|---|---|
tuberculous empyema |
|
|
trichotillomania |
|
|
maxillary sinus inverted papilloma |
|
|
maxillary sinus benign neoplasm |
|
|
stereotypic movement disorder |
|
|