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MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000,... See more...
Aliases for CLNK Gene
Aliases for CLNK Gene
External Ids for CLNK Gene
- HGNC: 17438
- Entrez Gene: 116449
- Ensembl: ENSG00000109684
- OMIM: 611434
- UniProtKB: Q7Z7G1
Previous GeneCards Identifiers for CLNK Gene
- GC04M010100
- GC04M009825
Summaries for CLNK Gene
-
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CLNK Gene
CLNK (Cytokine Dependent Hematopoietic Cell Linker) is a Protein Coding gene. Diseases associated with CLNK include Tuberculous Empyema and Trichotillomania. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is LCP2.
UniProtKB/Swiss-Prot Summary for CLNK Gene
-
An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity).
Additional gene information for CLNK Gene
- HGNC(17438)
- Entrez Gene(116449)
- Ensembl(ENSG00000109684)
- OMIM(611434)
- UniProtKB(Q7Z7G1)
- Open Targets Platform(ENSG00000109684)
- Monarch Initiative
- Search for CLNK at DataMed
- Search for CLNK at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLNK Gene
Genomics for CLNK Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CLNK Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J010683 | Promoter/Enhancer | 1.1 | EPDnew Ensembl ENCODE | 600.2 | +50.4 | 50355 | 1.6 | POLR2A SMAD5 RELA RUNX3 GATAD2B BCL11A ELF1 IKZF1 NR2F1 SPI1 | ENSG00000249334 CLNK LOC105374480 ZNF518B | |
| GH04J010732 | Enhancer | 0.9 | Ensembl ENCODE | 600.7 | +1.9 | 1852 | 1.6 | SP1 LARP7 RELA TCF12 IKZF2 POLR2A TRIM22 PKNOX1 EED ZSCAN29 | CLNK HS3ST1 ENSG00000249334 ZNF518B | |
| GH04J010734 | Promoter | 0.7 | EPDnew | 600.7 | 0.0 | -7 | 0.1 | TCF12 IKZF2 RFX1 IKZF1 TBX21 MTA2 BHLHE40 EGR1 RAD51 | CLNK LINC02498 HS3ST1 | |
| GH04J010668 | Promoter | 0.3 | EPDnew | 600.2 | +65.9 | 65931 | 0.1 | CLNK ENSG00000249334 LOC105374480 ZNF518B | ||
| GH04J010611 | Enhancer | 0.8 | Ensembl ENCODE | 11.8 | +123.0 | 122952 | 1.4 | PRDM10 PRDM1 ZNF600 ZNF639 JUND CEBPB ZEB1 ZBTB48 FOS ZNF189 | ENSG00000249334 CLNK HS3ST1 HSALNG0032894 piR-56133-159 ZNF518B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CLNK on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLNK
- Top Transcription factor binding sites by QIAGEN in the CLNK gene promoter:
-
- Evi-1
- GR
- GR-alpha
- HNF-4alpha1
- HNF-4alpha2
- Pax-4a
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- SRF (504 AA)
Genomic Locations for CLNK Gene
Genomic Locations for CLNK Gene
- chr4:10,486,395-10,734,853
- (GRCh38/hg38)
- Size:
- 248,459 bases
- Orientation:
- Minus strand
- chr4:10,488,019-10,686,489
- (GRCh37/hg19)
- Size:
- 198,471 bases
- Orientation:
- Minus strand
Genomic View for CLNK Gene
Genes around CLNK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.1 by HGNC
- 4p16.1 by Entrez Gene
- 4p16.1 by Ensembl
CLNK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLNK Gene
Proteins for CLNK Gene
-
Protein details for CLNK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z7G1-CLNK_HUMAN
- Recommended name:
- Cytokine-dependent hematopoietic cell linker
- Protein Accession:
- Q7Z7G1
- Q05C27
- Q9P2U9
Protein attributes for CLNK Gene
- Size:
- 428 amino acids
- Molecular mass:
- 49554 Da
- Quaternary structure:
-
- When phosphorylated, interacts with PLCG1, PLCG2, GRB2, VAV and LAT (By similarity). Interacts with LBR and AGO2 (PubMed:26009488). Interacts with FGR (By similarity). Part of a complex consisting of CLNK, SKAP1 and FYB1 (By similarity). Interacts (via SH2 domain) with FYB1; this interaction allows SKAP1 and FYB1 to promote tyrosine phosphorylation of CLNK by LYN (By similarity). Interacts (via SH2 domain) with MAP4K1 (By similarity).
Protein Expression for CLNK Gene
Post-translational modifications for CLNK Gene
- Tyrosine-phosphorylated upon BCR cross-linking. Tyrosine phosphorylation at both Tyr-69 and Tyr-96 are required for BCR-induced calcium response and are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40 cells, but this phosphorylation is dispensable in cells expressing LAT. Interacts with the SH2 domain of PLCG1 via phosphorylated Tyr-96 (By similarity). Tyrosine phosphorylation is increased when complexed with SKAP1 and FYB1 (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CLNK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CLNK
- Novus Biologicals Antibodies for CLNK
- Invitrogen Antibodies for CLNK (AFLGC-CLNK)
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CLNK
- Origene Custom Protein Services for CLNK
- antibodies-online: Show 4 available CLNK Proteins ranked by validation data
- Compare Top CLNK Proteins
-
Quality Products:
No data available for DME Specific Peptides for CLNK Gene
Domains & Families for CLNK Gene
Gene Families for CLNK Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CLNK Gene
- InterPro:
- Blocks:
-
- SH2 domain signature
- ProtoNet:
Suggested Antigen Peptide Sequences for CLNK Gene
- GenScript: Design optimal peptide antigens:
-
- Mast cell immunoreceptor signal transducer (CLNK_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q7Z7G1UniProtKB/Swiss-Prot:
CLNK_HUMAN :- The N-terminal proline-rich region interacts with the SH3 domain of PLCG1.
- Domain:
-
- The N-terminal proline-rich region interacts with the SH3 domain of PLCG1.
- The SH2 domain is important for restoration of BCR-induced calcium response and JNK2 activation in BLNK-deficient DT40 cells expressing LAT.
Function for CLNK Gene
Molecular function for CLNK Gene
- UniProtKB/Swiss-Prot Function:
- An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity).
Phenotypes From GWAS Catalog for CLNK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | NAS | -- |
| GO:0005515 | protein binding | IPI | 16273093 |
| GO:0044877 | protein-containing complex binding | IEA | -- |
Phenotypes for CLNK Gene
- MGI mutant phenotypes for CLNK:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CLNK:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Increased transferrin (TF) endocytosis
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased shRNA abundance (Z-score > 2)
Animal Model Products
-
Taconic Biosciences Mouse Models for CLNK
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLNK - Select products 50% OFF >
- * CLNK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CLNK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLNK
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLNK
miRNA for CLNK Gene
- miRTarBase miRNAs that target CLNK
-
- hsa-miR-4659b-3p (MIRT621375)
- hsa-miR-4659a-3p (MIRT621376)
- hsa-miR-6875-3p (MIRT621377)
- hsa-miR-4652-3p (MIRT621378)
- hsa-miR-629-3p (MIRT621379)
- hsa-miR-6867-3p (MIRT621380)
- hsa-miR-4713-5p (MIRT621381)
- hsa-miR-211-5p (MIRT621382)
- hsa-miR-204-5p (MIRT621383)
- hsa-miR-3682-5p (MIRT621384)
- hsa-miR-3182 (MIRT621385)
- hsa-miR-942-5p (MIRT621386)
- hsa-miR-4685-3p (MIRT621387)
- hsa-miR-4287 (MIRT621388)
- hsa-miR-7113-3p (MIRT621389)
- hsa-miR-4469 (MIRT621390)
- hsa-miR-6832-3p (MIRT621391)
- hsa-miR-6768-5p (MIRT650688)
- hsa-miR-8485 (MIRT650689)
- hsa-miR-548x-3p (MIRT650690)
- hsa-miR-548j-3p (MIRT650691)
- hsa-miR-548aq-3p (MIRT650692)
- hsa-miR-548am-3p (MIRT650693)
- hsa-miR-548aj-3p (MIRT650694)
- hsa-miR-548ah-3p (MIRT650695)
- hsa-miR-548ae-3p (MIRT650696)
- hsa-miR-548z (MIRT650697)
- hsa-miR-548h-3p (MIRT650698)
- hsa-miR-548d-3p (MIRT650699)
- hsa-miR-548bb-3p (MIRT650700)
- hsa-miR-548ac (MIRT650701)
- hsa-miR-1228-3p (MIRT761422)
- hsa-miR-1976 (MIRT763550)
- hsa-miR-3653-5p (MIRT766346)
- hsa-miR-377-3p (MIRT767345)
- hsa-miR-4279 (MIRT768296)
- hsa-miR-4722-3p (MIRT771465)
- hsa-miR-4740-3p (MIRT771855)
- hsa-miR-6727-3p (MIRT777867)
- hsa-miR-6747-3p (MIRT778256)
- hsa-miR-6778-3p (MIRT778797)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLNK
- Browse OriGene Inhibitory RNA Products For CLNK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLNK
Clone Products
- Applied Biological Materials (abm): Clones for CLNK - Select products 50% OFF >
- * CLNK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CLNK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLNK
Cell Line Products
-
Horizon Cell Lines for CLNK
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLNK Gene
Localization for CLNK Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLNK Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| extracellular | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IMP | 26009488 |
| GO:0032991 | protein-containing complex | IEA | -- |
Pathways & Interactions for CLNK Gene
Interacting Proteins for CLNK Gene
Selected Interacting proteins:
Q7Z7G1-CLNK_HUMAN
ENSP00000226951
for CLNK Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CLNK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002729 | positive regulation of natural killer cell cytokine production | IEA | -- |
| GO:0006955 | immune response | NAS | 10744659 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | 21873635 |
| GO:0009967 | positive regulation of signal transduction | IEA | -- |
| GO:0010941 | regulation of cell death | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CLNK Gene
Transcripts for CLNK Gene
mRNA/cDNA for CLNK Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000226951 5502 nts (view in UCSC)
- ENST00000515667 4180 nts (view in UCSC)
- ENST00000507719 1143 nts (view in UCSC)
- ENST00000442825 1539 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLNK - Select products 50% OFF >
- * CLNK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CLNK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLNK
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLNK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLNK
- Browse OriGene Inhibitory RNA Products For CLNK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLNK
Clone Products
- Applied Biological Materials (abm): Clones for CLNK - Select products 50% OFF >
- * CLNK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CLNK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLNK
Relevant External Links for CLNK Gene
- GeneLoc Exon Structure for
- CLNK
Expression for CLNK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Conventional Dendritic Cells I Spleen
- Hematopoietic Bone Marrow
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
- Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CLNK Gene
This gene is overexpressed in Kidney - Cortex (x12.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLNK Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLNK
SOURCE GeneReport for Unigene cluster for CLNK Gene:
Hs.678910Evidence on tissue expression from TISSUES for CLNK Gene
- Nervous system(4.4)
- Skin(2.5)
- Heart(2.3)
- Blood(2.3)
Primer Products
-
OriGene qPCR primer pairs for CLNK
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLNK Gene
Orthologs for CLNK Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CLNK 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CLNK 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CLNK 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Clnk 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Clnk 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CLNK 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | SLP76 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | CLNK 31 |
|
OneToOne |
- Species where no ortholog for CLNK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CLNK Gene
- ENSEMBL:
- Gene Tree for CLNK (if available)
- TreeFam:
- Gene Tree for CLNK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CLNK: view image
Paralogs for CLNK Gene
Variants for CLNK Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLNK Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2903960 | Benign: not specified | 10,501,313(-) | T/G | SYNONYMOUS_VARIANT | |
| rs61759824 | Benign: not specified | 10,584,947(-) | G/A | MISSENSE_VARIANT | |
| rs16869924 | - | p.Ser65Gly |
Residual Variation Intolerance Score:
66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.55;
55.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLNK Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLNK Gene
Disorders for CLNK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tuberculous empyema |
|
|
| trichotillomania |
|
|
| maxillary sinus inverted papilloma |
|
|
| maxillary sinus benign neoplasm |
|
|
| stereotypic movement disorder |
|
|
Search CLNK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CLNK
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CLNK Gene
Publications for CLNK Gene
- A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation. (PMID: 10744659) Goitsuka R … Kitamura D (International immunology 2000) 2 3 4
- Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929. (PMID: 26009488) Xu M … Zhou H (Biochemical and biophysical research communications 2015) 3 4
- Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells. (PMID: 10562326) Cao MY … Veillette A (The Journal of experimental medicine 1999) 2 3
- LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. (PMID: 30631154) Hu Q … Yang L (Cell research 2019) 3
- WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients. (PMID: 26438387) Lan B … Kang L (Rheumatology international 2016) 3
ExternalLinks
Products for CLNK Gene
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- Custom Assay Services
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- Origene Custom Protein Services for CLNK
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- Browse OriGene Inhibitory RNA Products For CLNK
- OriGene qPCR primer pairs for CLNK
- OriGene CRISPR knockouts for CLNK
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- Sino Biological Human cDNA Clone for CLNK
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Novus Biologicals proteins and lysates for CLNK
- Browse Antibodies
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- Browse ELISA Kits
- Taconic Biosciences Mouse Models for CLNK
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CLNK (AFLGC-CLNK)
- VectorBuilder Custom and pre-made DNA vectors for CLNK (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CLNK (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CLNK (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CLNK CRISPR vectors (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 9 available CLNK Antibodies ranked by validation data
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- antibodies-online: Search results for available CLNK related products ranked by validation data
- antibodies-online: Show 4 available CLNK Proteins ranked by validation data
- Compare Top CLNK Proteins
- Quality Products:
- Horizon Cell Lines for CLNK
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLNK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLNK
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CLNK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLNK
Sources for CLNK Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB