Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]
CLMP (CXADR Like Membrane Protein) is a Protein Coding gene. Diseases associated with CLMP include Congenital Short Bowel Syndrome and Intestinal Pseudo-Obstruction. An important paralog of this gene is CXADR.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005881 | cytoplasmic microtubule | IDA | 23264731 |
GO:0005886 | plasma membrane | IEA | -- |
GO:0005923 | bicellular tight junction | IEA,IDA | 22155368 |
GO:0009986 | cell surface | HDA | 19581412 |
GO:0016020 | membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0048565 | digestive tract development | IMP | 22155368 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||
SP2: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CLMP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CLMP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ASAM 31 |
|
OneToOne | |
CLMP 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Clmp 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Clmp 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CLMP 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CLMP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CLMP 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CLMP 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | clmp 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100330877 30 |
|
||
CLMP 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
717448 | Likely Benign: not provided | 123,097,933(-) | G/C | SYNONYMOUS_VARIANT | |
717942 | Benign: not provided | 123,083,828(-) | C/T | SYNONYMOUS_VARIANT | |
719365 | Benign: not provided | 123,097,818(-) | C/T | MISSENSE_VARIANT | |
753985 | Likely Benign: not provided | 123,073,564(-) | T/C | SYNONYMOUS_VARIANT | |
784224 | Benign: not provided | 123,083,783(-) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2745163 | CNV | deletion | 23290073 |
esv2745165 | CNV | deletion | 23290073 |
esv3548445 | CNV | deletion | 23714750 |
nsv1039284 | CNV | gain | 25217958 |
nsv1122675 | CNV | deletion | 24896259 |
nsv1146235 | CNV | deletion | 26484159 |
Disorder | Aliases | PubMed IDs |
---|---|---|
congenital short bowel syndrome |
|
|
intestinal pseudo-obstruction |
|
|
short bowel syndrome |
|
|
barbiturate abuse |
|
|
interstitial myocarditis |
|
|