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Aliases for CLLU1OS Gene

Aliases for CLLU1OS Gene

  • Chronic Lymphocytic Leukemia Up-Regulated 1 Opposite Strand 2 3 5
  • Chronic Lymphocytic Leukemia Up-Regulated 1 Overlapping Strand 2 3
  • Putative Chronic Lymphocytic Leukemia Up-Regulated Protein 1 Opposite Strand Transcript Protein 3

External Ids for CLLU1OS Gene

Previous GeneCards Identifiers for CLLU1OS Gene

  • GC12U900503
  • GC12M091338
  • GC12M092813
  • GC12M089882

Summaries for CLLU1OS Gene

GeneCards Summary for CLLU1OS Gene

CLLU1OS (Chronic Lymphocytic Leukemia Up-Regulated 1 Opposite Strand) is a Protein Coding gene.

Additional gene information for CLLU1OS Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLLU1OS Gene

Genomics for CLLU1OS Gene

GeneHancer (GH) Regulatory Elements for CLLU1OS Gene

Promoters and enhancers for CLLU1OS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J092459 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.4 -38.4 -38358 13.8 HDGF PKNOX1 SMAD1 SIN3A IRF4 TCF12 ZNF207 ZNF143 ATF7 RUNX3 LINC02397 CLLU1OS C12orf74 CLLU1 BTG1 LOC105369904 ENSG00000266923
GH12J092431 Enhancer 1.2 Ensembl ENCODE dbSUPER 22.7 -5.3 -5282 4.3 HDGF PKNOX1 SMAD1 RB1 BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 CLLU1OS ENSG00000266923 LINC02397
GH12J092002 Enhancer 1.1 FANTOM5 ENCODE 18.6 +425.8 425753 1.4 HDAC1 TCF12 GATA2 RCOR1 NCOA1 GATAD2B ZEB2 MEF2D NFIC PRDM6 CLLU1OS CLLU1 LOC105369901 GC12P092067 LINC01619
GH12J092537 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -114.6 -114608 11.6 HDGF PKNOX1 ATF1 FOXA2 SMAD1 NEUROD1 YBX1 IRF4 YY1 ZNF207 LINC02397 CLLU1OS BTG1 CLLU1 EEA1 LOC100132126 LOC105369905
GH12J092396 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.1 +27.2 27202 10.1 HDGF PKNOX1 SMAD1 ARNT IRF4 ZNF766 ZNF143 FOS REST ZNF592 CLLU1OS PIR32184 ENSG00000266923 CLLU1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLLU1OS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLLU1OS gene promoter:

Genomic Locations for CLLU1OS Gene

Genomic Locations for CLLU1OS Gene
chr12:92,420,094-92,428,545
(GRCh38/hg38)
Size:
8,452 bases
Orientation:
Minus strand
chr12:92,813,870-92,821,924
(GRCh37/hg19)

Genomic View for CLLU1OS Gene

Genes around CLLU1OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLLU1OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLLU1OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLLU1OS Gene

Proteins for CLLU1OS Gene

  • Protein details for CLLU1OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5K130-CLU1O_HUMAN
    Recommended name:
    Putative chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein
    Protein Accession:
    Q5K130

    Protein attributes for CLLU1OS Gene

    Size:
    101 amino acids
    Molecular mass:
    10963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLLU1OS Gene

Post-translational modifications for CLLU1OS Gene

No Post-translational modifications

Other Protein References for CLLU1OS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLLU1OS Gene

Domains & Families for CLLU1OS Gene

Gene Families for CLLU1OS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CLLU1OS Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CLLU1OS Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLLU1OS: view

No data available for UniProtKB/Swiss-Prot for CLLU1OS Gene

Function for CLLU1OS Gene

Phenotypes for CLLU1OS Gene

genes like me logo Genes that share phenotypes with CLLU1OS: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLLU1OS Gene

Localization for CLLU1OS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLLU1OS gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CLLU1OS Gene

Pathways & Interactions for CLLU1OS Gene

SuperPathways for CLLU1OS Gene

No Data Available

Interacting Proteins for CLLU1OS Gene

Gene Ontology (GO) - Biological Process for CLLU1OS Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLLU1OS Gene

Drugs & Compounds for CLLU1OS Gene

No Compound Related Data Available

Transcripts for CLLU1OS Gene

mRNA/cDNA for CLLU1OS Gene

(1) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLLU1OS Gene

Chronic lymphocytic leukemia up-regulated 1 opposite strand:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLLU1OS Gene

No ASD Table

Relevant External Links for CLLU1OS Gene

GeneLoc Exon Structure for
CLLU1OS
ECgene alternative splicing isoforms for
CLLU1OS

Expression for CLLU1OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLLU1OS Gene

mRNA differential expression in normal tissues according to GTEx for CLLU1OS Gene

This gene is overexpressed in Minor Salivary Gland (x4.2).

Protein differential expression in normal tissues from HIPED for CLLU1OS Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLLU1OS Gene



Protein tissue co-expression partners for CLLU1OS Gene

NURSA nuclear receptor signaling pathways regulating expression of CLLU1OS Gene:

CLLU1OS

SOURCE GeneReport for Unigene cluster for CLLU1OS Gene:

Hs.551199
genes like me logo Genes that share expression patterns with CLLU1OS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLLU1OS Gene

Orthologs for CLLU1OS Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CLLU1OS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLLU1OS 34 33
  • 99.56 (n)
OneToOne
Species where no ortholog for CLLU1OS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLLU1OS Gene

ENSEMBL:
Gene Tree for CLLU1OS (if available)
TreeFam:
Gene Tree for CLLU1OS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLLU1OS: view image

Paralogs for CLLU1OS Gene

No data available for Paralogs for CLLU1OS Gene

Variants for CLLU1OS Gene

Sequence variations from dbSNP and Humsavar for CLLU1OS Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000249161 -- 92,421,026(-) G/C coding_sequence_variant, missense_variant
rs1000521040 -- 92,423,868(-) G/A intron_variant
rs1000552162 -- 92,423,375(-) G/A intron_variant
rs1000705346 -- 92,429,366(-) G/A upstream_transcript_variant
rs1001530177 -- 92,425,906(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLLU1OS Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER inversion 18451855

Variation tolerance for CLLU1OS Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLLU1OS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLLU1OS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLLU1OS Gene

Disorders for CLLU1OS Gene

Additional Disease Information for CLLU1OS

No disorders were found for CLLU1OS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLLU1OS Gene

Publications for CLLU1OS Gene

  1. Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia. (PMID: 16339396) Buhl AM … Leffers H (Blood 2006) 3 4 58

Products for CLLU1OS Gene

Sources for CLLU1OS Gene

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