Aliases for CLIP4 Gene

Aliases for CLIP4 Gene

  • CAP-Gly Domain Containing Linker Protein Family Member 4 2 3 5
  • CAP-GLY Domain Containing Linker Protein Family, Member 4 2 3
  • CAP-Gly Domain-Containing Linker Protein 4 3 4
  • Restin-Like Protein 2 3 4
  • RSNL2 3 4
  • Restin-Like 2 2

External Ids for CLIP4 Gene

Previous HGNC Symbols for CLIP4 Gene

  • RSNL2

Previous GeneCards Identifiers for CLIP4 Gene

  • GC02P029191
  • GC02P029320
  • GC02P029085

Summaries for CLIP4 Gene

GeneCards Summary for CLIP4 Gene

CLIP4 (CAP-Gly Domain Containing Linker Protein Family Member 4) is a Protein Coding gene. An important paralog of this gene is CLIP3.

Additional gene information for CLIP4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLIP4 Gene

Genomics for CLIP4 Gene

GeneHancer (GH) Regulatory Elements for CLIP4 Gene

Promoters and enhancers for CLIP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J029112 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.4 +19.3 19256 9.2 SIN3A GATA3 ZBTB6 POLR2A USF2 ZNF217 ZNF362 HLF CEBPB NKRF NONHSAG027370.2 CLIP4 TOGARAM2 PCARE lnc-C2orf71-7
GH02J029096 Enhancer 0.3 Ensembl 750.6 -0.7 -675 0.4 CEBPA ENSG00000229224 CLIP4 LOC105374386 piR-37026-329
GH02J029126 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +31.3 31261 4.5 SIN3A SP1 MAFK BACH1 SMARCA4 GATAD2A NFE2L2 ZNF316 JUND NFE2 lnc-C2orf71-7 CLIP4 ENSG00000229224 PCARE NONHSAG027370.2
GH02J029165 Enhancer 1 Ensembl ENCODE 11.5 +67.8 67825 3 TCF7L2 CREB1 HLF BCL6B ELF3 SP1 MAFK CEBPG TFE3 SP7 TOGARAM2 CLIP4 ENSG00000229224 PCARE HSALNG0013924 RF00017-3150
GH02J029053 Enhancer 0.7 Ensembl ENCODE dbSUPER 15.8 -44.3 -44275 2 CTCF RAD21 SMC3 CLIP4 TOGARAM2 ENSG00000229224 PCARE piR-56580-019 HSALNG0013913
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLIP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLIP4 gene promoter:
  • AREB6
  • Arnt
  • C/EBPalpha
  • E2F
  • E2F-1
  • GATA-1
  • HNF-1
  • HNF-1A
  • STAT5A
  • TGIF

Genomic Locations for CLIP4 Gene

Genomic Locations for CLIP4 Gene
91,968 bases
Plus strand
91,939 bases
Plus strand

Genomic View for CLIP4 Gene

Genes around CLIP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLIP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLIP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIP4 Gene

Proteins for CLIP4 Gene

  • Protein details for CLIP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CAP-Gly domain-containing linker protein 4
    Protein Accession:
    Secondary Accessions:
    • A0AV10
    • B2RMQ3
    • B7Z7N8
    • Q7Z4U3
    • Q96BR7
    • Q96MA5
    • Q9H7C0

    Protein attributes for CLIP4 Gene

    705 amino acids
    Molecular mass:
    76317 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14974.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLIP4 Gene

    Alternative splice isoforms for CLIP4 Gene


neXtProt entry for CLIP4 Gene

Post-translational modifications for CLIP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CLIP4 Gene

Domains & Families for CLIP4 Gene

Gene Families for CLIP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CLIP4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75496, highly similar to Homo sapiens restin-like 2 (RSNL2), mRNA (A8K6D0_HUMAN)
  • Restin-like protein 2 (CLIP4_HUMAN)
genes like me logo Genes that share domains with CLIP4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CLIP4 Gene

Function for CLIP4 Gene

Phenotypes From GWAS Catalog for CLIP4 Gene

Gene Ontology (GO) - Molecular Function for CLIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CLIP4: view
genes like me logo Genes that share phenotypes with CLIP4: view

Animal Model Products

CRISPR Products

miRNA for CLIP4 Gene

miRTarBase miRNAs that target CLIP4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLIP4 Gene

Localization for CLIP4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLIP4 gene
Compartment Confidence
cytosol 3
nucleus 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CLIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CLIP4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CLIP4 Gene

Pathways & Interactions for CLIP4 Gene

PathCards logo

SuperPathways for CLIP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLIP4 Gene


No data available for Pathways by source and SIGNOR curated interactions for CLIP4 Gene

Drugs & Compounds for CLIP4 Gene

No Compound Related Data Available

Transcripts for CLIP4 Gene

mRNA/cDNA for CLIP4 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLIP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP7: -

Relevant External Links for CLIP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLIP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLIP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLIP4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for CLIP4 Gene

This gene is overexpressed in Cerebrospinal fluid (33.6), Breast (11.0), Plasma (10.2), and Spleen (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CLIP4 Gene

Protein tissue co-expression partners for CLIP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLIP4 Gene:


SOURCE GeneReport for Unigene cluster for CLIP4 Gene:


Evidence on tissue expression from TISSUES for CLIP4 Gene

  • Nervous system(4.6)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with CLIP4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLIP4 Gene

Orthologs for CLIP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLIP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLIP4 33 32
  • 99.57 (n)
(Bos Taurus)
Mammalia CLIP4 33
  • 91 (a)
(Canis familiaris)
Mammalia CLIP4 33 32
  • 88.38 (n)
(Rattus norvegicus)
Mammalia Clip4 32
  • 83.95 (n)
(Mus musculus)
Mammalia Clip4 17 33 32
  • 82.77 (n)
(Ornithorhynchus anatinus)
Mammalia CLIP4 33
  • 82 (a)
(Monodelphis domestica)
Mammalia CLIP4 33
  • 77 (a)
(Gallus gallus)
Aves CLIP4 33 32
  • 75.15 (n)
(Anolis carolinensis)
Reptilia CLIP4 33
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495216 32
  • 63.6 (n)
(Danio rerio)
Actinopterygii CLIP4 (1 of 2) 33
  • 66 (a)
CLIP4 (2 of 2) 33
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP100 33
  • 4 (a)
Species where no ortholog for CLIP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLIP4 Gene

Gene Tree for CLIP4 (if available)
Gene Tree for CLIP4 (if available)
Evolutionary constrained regions (ECRs) for CLIP4: view image

Paralogs for CLIP4 Gene

Paralogs for CLIP4 Gene

(2) SIMAP similar genes for CLIP4 Gene using alignment to 6 proteins:

  • E7EW06_HUMAN
genes like me logo Genes that share paralogs with CLIP4: view

Variants for CLIP4 Gene

Sequence variations from dbSNP and Humsavar for CLIP4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000050873 -- 29,137,188(+) C/G intron_variant
rs1000092482 -- 29,102,884(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000122461 -- 29,136,177(+) TTGTTGTTGTTGTT/TTGTTGTTGTT intron_variant
rs1000147276 -- 29,151,865(+) A/T intron_variant
rs1000206859 -- 29,156,162(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLIP4 Gene

Variant ID Type Subtype PubMed ID
dgv6746n54 CNV gain+loss 21841781
esv27586 CNV loss 19812545
esv2759035 CNV gain 17122850
esv34904 CNV gain 17911159
nsv1008490 CNV gain 25217958
nsv2658 CNV deletion 18451855
nsv581248 CNV loss 21841781
nsv581250 CNV gain 21841781
nsv581252 CNV gain 21841781
nsv581253 CNV loss 21841781
nsv998151 CNV loss 25217958

Variation tolerance for CLIP4 Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLIP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIP4 Gene

Disorders for CLIP4 Gene

Additional Disease Information for CLIP4

No disorders were found for CLIP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLIP4 Gene

Publications for CLIP4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. (PMID: 30217970) Yang JS … Maurer SP (Nature communications 2018) 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. FOXC2 and CLIP4 : a potential biomarker for synchronous metastasis of ≤7-cm clear cell renal cell carcinomas. (PMID: 27283491) Ahn J … Ham WS (Oncotarget 2016) 3 56

Products for CLIP4 Gene

Sources for CLIP4 Gene