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Aliases for CLIP4 Gene

Aliases for CLIP4 Gene

  • CAP-Gly Domain Containing Linker Protein Family Member 4 2 3 5
  • CAP-GLY Domain Containing Linker Protein Family, Member 4 2 3
  • Restin-Like Protein 2 3 4
  • RSNL2 3 4
  • CAP-Gly Domain-Containing Linker Protein 4 3
  • Restin-Like 2 2

External Ids for CLIP4 Gene

Previous HGNC Symbols for CLIP4 Gene

  • RSNL2

Previous GeneCards Identifiers for CLIP4 Gene

  • GC02P029191
  • GC02P029320

Summaries for CLIP4 Gene

GeneCards Summary for CLIP4 Gene

CLIP4 (CAP-Gly Domain Containing Linker Protein Family Member 4) is a Protein Coding gene. An important paralog of this gene is CLIP3.

Additional gene information for CLIP4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIP4 Gene

Genomics for CLIP4 Gene

GeneHancer (GH) Regulatory Elements for CLIP4 Gene

Promoters and enhancers for CLIP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I029112 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.4 +19.3 19256 9.2 PKNOX1 SIN3A GLIS2 ZNF207 FOS RUNX3 SP3 JUNB REST ZNF592 CLIP4 TOGARAM2 C2orf71 GC02P029290
GH02I029097 Promoter 0.5 EPDnew 550.8 +0.0 32 0.1 CLIP4 LOC105374386 GC02P029290
GH02I029126 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +31.3 31261 4.5 FOXA2 TAF9B SIN3A BATF IRF4 RFX5 YY1 FOS RUNX3 ZNF592 LOC105374386 CLIP4 C2orf71 GC02P029290
GH02I029122 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 +26.4 26380 3.6 ELF3 FOXA2 SIN3A THRB RARA FOS USF2 CEBPB REST SP1 CLIP4 LOC105374386 C2orf71 GC02P029290
GH02I029063 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.7 -32.2 -32205 4.5 ATF4 HLF CEBPA CEBPB CEBPG LOC105374385 LOC105374386 C2orf71 CLIP4 TOGARAM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLIP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLIP4 gene promoter:

Genomic Locations for CLIP4 Gene

Genomic Locations for CLIP4 Gene
chr2:29,097,676-29,189,643
(GRCh38/hg38)
Size:
91,968 bases
Orientation:
Plus strand
chr2:29,320,571-29,412,509
(GRCh37/hg19)

Genomic View for CLIP4 Gene

Genes around CLIP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLIP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLIP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIP4 Gene

Proteins for CLIP4 Gene

  • Protein details for CLIP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3C7-CLIP4_HUMAN
    Recommended name:
    CAP-Gly domain-containing linker protein 4
    Protein Accession:
    Q8N3C7
    Secondary Accessions:
    • A0AV10
    • B2RMQ3
    • B7Z7N8
    • Q7Z4U3
    • Q96BR7
    • Q96MA5
    • Q9H7C0

    Protein attributes for CLIP4 Gene

    Size:
    705 amino acids
    Molecular mass:
    76317 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14974.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLIP4 Gene

    Alternative splice isoforms for CLIP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLIP4 Gene

Post-translational modifications for CLIP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CLIP4 Gene

Domains & Families for CLIP4 Gene

Gene Families for CLIP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CLIP4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLIP4: view

No data available for UniProtKB/Swiss-Prot for CLIP4 Gene

Function for CLIP4 Gene

Gene Ontology (GO) - Molecular Function for CLIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CLIP4: view
genes like me logo Genes that share phenotypes with CLIP4: view

Animal Model Products

miRNA for CLIP4 Gene

miRTarBase miRNAs that target CLIP4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLIP4 Gene

Localization for CLIP4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLIP4 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CLIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CLIP4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CLIP4 Gene

Pathways & Interactions for CLIP4 Gene

SuperPathways for CLIP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLIP4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLIP4 Gene

Drugs & Compounds for CLIP4 Gene

No Compound Related Data Available

Transcripts for CLIP4 Gene

Unigene Clusters for CLIP4 Gene

CAP-GLY domain containing linker protein family, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLIP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for CLIP4 Gene

GeneLoc Exon Structure for
CLIP4
ECgene alternative splicing isoforms for
CLIP4

Expression for CLIP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLIP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLIP4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for CLIP4 Gene

This gene is overexpressed in Cerebrospinal fluid (33.6), Breast (11.0), Plasma (10.2), and Spleen (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLIP4 Gene



Protein tissue co-expression partners for CLIP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLIP4 Gene:

CLIP4

SOURCE GeneReport for Unigene cluster for CLIP4 Gene:

Hs.122927

Evidence on tissue expression from TISSUES for CLIP4 Gene

  • Nervous system(4.6)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with CLIP4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLIP4 Gene

Orthologs for CLIP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLIP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLIP4 33 34
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia CLIP4 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLIP4 33 34
  • 88.38 (n)
rat
(Rattus norvegicus)
Mammalia Clip4 33
  • 83.95 (n)
mouse
(Mus musculus)
Mammalia Clip4 33 16 34
  • 82.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CLIP4 34
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLIP4 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLIP4 33 34
  • 75.15 (n)
lizard
(Anolis carolinensis)
Reptilia CLIP4 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495216 33
  • 63.6 (n)
zebrafish
(Danio rerio)
Actinopterygii CLIP4 (1 of 2) 34
  • 66 (a)
OneToMany
CLIP4 (2 of 2) 34
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP100 34
  • 4 (a)
OneToMany
Species where no ortholog for CLIP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLIP4 Gene

ENSEMBL:
Gene Tree for CLIP4 (if available)
TreeFam:
Gene Tree for CLIP4 (if available)

Paralogs for CLIP4 Gene

Paralogs for CLIP4 Gene

(2) SIMAP similar genes for CLIP4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CLIP4: view

Variants for CLIP4 Gene

Sequence variations from dbSNP and Humsavar for CLIP4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000050873 -- 29,137,188(+) C/G intron_variant
rs1000092482 -- 29,102,884(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000122461 -- 29,136,177(+) TTGTTGTTGTTGTT/TTGTTGTTGTT intron_variant
rs1000147276 -- 29,151,865(+) A/T intron_variant
rs1000206859 -- 29,156,162(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLIP4 Gene

Variant ID Type Subtype PubMed ID
dgv6746n54 CNV gain+loss 21841781
esv27586 CNV loss 19812545
esv2759035 CNV gain 17122850
esv34904 CNV gain 17911159
nsv1008490 CNV gain 25217958
nsv2658 CNV deletion 18451855
nsv581248 CNV loss 21841781
nsv581250 CNV gain 21841781
nsv581252 CNV gain 21841781
nsv581253 CNV loss 21841781
nsv998151 CNV loss 25217958

Variation tolerance for CLIP4 Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLIP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLIP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIP4 Gene

Disorders for CLIP4 Gene

Additional Disease Information for CLIP4

No disorders were found for CLIP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLIP4 Gene

Publications for CLIP4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. (PMID: 26272612) Dai FF … Wheeler MB (The Journal of biological chemistry 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for CLIP4 Gene

Sources for CLIP4 Gene

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