Aliases for CLIP3 Gene
External Ids for CLIP3 Gene
Previous GeneCards Identifiers for CLIP3 Gene
This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for CLIP3 Gene
CLIP3 (CAP-Gly Domain Containing Linker Protein 3) is a Protein Coding gene. Among its related pathways are TNF signaling (REACTOME) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include microtubule binding and ganglioside binding. An important paralog of this gene is CLIP4.
UniProtKB/Swiss-Prot for CLIP3 Gene
Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.