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The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] See more...
Aliases for CLIP1 Gene
Aliases for CLIP1 Gene
External Ids for CLIP1 Gene
- HGNC: 10461
- NCBI Entrez Gene: 6249
- Ensembl: ENSG00000130779
- OMIM®: 179838
- UniProtKB/Swiss-Prot: P30622
Previous HGNC Symbols for CLIP1 Gene
- RSN
Previous GeneCards Identifiers for CLIP1 Gene
- GC12M121322
- GC12M121205
- GC12M122755
- GC12M119716
Summaries for CLIP1 Gene
-
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for CLIP1 Gene
CLIP1 (CAP-Gly Domain Containing Linker Protein 1) is a Protein Coding gene. Diseases associated with CLIP1 include Autosomal Recessive Non-Syndromic Intellectual Disability and Perry Syndrome. Among its related pathways are Signaling by GPCR and RHO GTPases activate IQGAPs. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and microtubule binding. An important paralog of this gene is CLIP2.
UniProtKB/Swiss-Prot Summary for CLIP1 Gene
-
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
Additional gene information for CLIP1 Gene
- HGNC (10461)
- NCBI Entrez Gene (6249)
- Ensembl (ENSG00000130779)
- OMIM® (179838)
- UniProtKB/Swiss-Prot (P30622)
- Open Targets Platform(ENSG00000130779)
- Monarch Initiative
- Search for CLIP1 at DataMed
- Search for CLIP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLIP1 Gene
Genomics for CLIP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CLIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CLIP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLIP1
- Top Transcription factor binding sites by QIAGEN in the CLIP1 gene promoter:
-
- AML1a
- FOXF2
- FOXO1
- HOXA3
- NF-kappaB1
- Nkx6-1
- p53
- RFX1
- YY1
Genomic Locations for CLIP1 Gene
Latest Assembly
- chr12:122,271,432-122,422,956
- (GRCh38/hg38)
- Size:
- 151,525 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:122,756,016-122,907,216
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 151,201 bases
- Orientation:
- Minus strand
- chr12:122,755,979-122,907,179
- (GRCh37/hg19 by Ensembl)
- Size:
- 151,201 bases
- Orientation:
- Minus strand
Genomic View for CLIP1 Gene
Genes around CLIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
CLIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLIP1 Gene
Proteins for CLIP1 Gene
-
Protein details for CLIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30622-CLIP1_HUMAN
- Recommended name:
- CAP-Gly domain-containing linker protein 1
- Protein Accession:
- P30622
- A0AVD3
- Q17RS4
- Q29RG0
Protein attributes for CLIP1 Gene
- Size:
- 1438 amino acids
- Molecular mass:
- 162246 Da
- Quaternary structure:
-
- Interacts with MTOR; phosphorylates and regulates CLIP1 (PubMed:12231510). Interacts (via CAP-Gly domains) with tubulin (PubMed:17563362, PubMed:17889670). Interacts with SLAIN2 (PubMed:21646404). Interacts (via zinc finger) with DCTN1 (PubMed:17828275, PubMed:20679239). Interacts with TUBA1B, MAPRE1 and MAPRE3 (PubMed:17563362). Binds preferentially to tyrosinated microtubules, and only marginally to detyrosinated microtubules (By similarity).
Three dimensional structures from OCA and Proteopedia for CLIP1 Gene
Protein Expression for CLIP1 Gene
Post-translational modifications for CLIP1 Gene
- Phosphorylated. Phosphorylation induces conformational changes by increasing the affinity of the N-terminus for C-terminus, resulting in inhibition of its function thus decreasing its binding to microtubules and DCTN1. Exhibits a folded, autoinhibited conformation when phosphorylated and an open conformation when dephosphorylated with increased binding affinity to microtubules and DCTN1. Phosphorylation regulates its recruitment to tyrosinated microtubules and the recruitment of vesicular cargo to microtubules in neurons (By similarity). Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules (PubMed:12231510).
-
Glycosylation at Asn187, Asn971, and Asn1263
- NX_P30622 (NX_P30622-3)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- CLIP1_HUMAN (643)
Other Protein References for CLIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CLIP1 / CLIP-170 Antibody (LS-B3615) and CLIP1 / CLIP-170 Antibody (LS-B15487)
- G Biosciences Immunotag™ CLIP1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CLIP1
- Novus Biologicals Antibodies for CLIP1
-
Abcam antibodies for CLIP1
- Invitrogen Antibodies for CLIP1 (AFLGC-CLIP1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CLIP1
- Sino Biological Antibodies for CLIP1
Protein products for research
-
OriGene Purified Proteins for CLIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for CLIP1
- Origene Custom Protein Services for CLIP1
- Novus Biologicals proteins for CLIP1
Assay products for research
No data available for DME Specific Peptides for CLIP1 Gene
Domains & Families for CLIP1 Gene
Gene Families for CLIP1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CLIP1 Gene
- InterPro:
- Blocks:
-
- C2HC-type zinc-finger signature
- CAP-Gly domain
- ProtoNet:
Suggested Antigen Peptide Sequences for CLIP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Restin (CLIP1_HUMAN)
- Cytoplasmic linker protein CLIP-170 (O43666_HUMAN)
- Cytoplasmic linker protein CLIP-170 (O43667_HUMAN)
- CLIP1 protein (Q6P5Z9_HUMAN)
- Restin isoform b (Q6Q318_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P30622UniProtKB/Swiss-Prot:
CLIP1_HUMAN :- Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin.
- Domain:
-
- Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin.
Function for CLIP1 Gene
Molecular function for CLIP1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
Phenotypes From GWAS Catalog for CLIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11940666 |
| GO:0008017 | microtubule binding | IDA | 17889670 |
| GO:0008270 | zinc ion binding | IDA | 17828275 |
| GO:0015631 | tubulin binding | IDA | 17889670 |
| GO:0042802 | identical protein binding | IPI | -- |
Phenotypes for CLIP1 Gene
- MGI mutant phenotypes for CLIP1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CLIP1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Models for CLIP1 Gene
- MGI Knock Outs for CLIP1:
-
- Clip1 Clip1<tm1.1Gal>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CLIP1 - Starting at $85 >
- * CLIP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CLIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLIP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLIP1
miRNA for CLIP1 Gene
- miRTarBase miRNAs that target CLIP1
-
- mmu-miR-324-3p (MIRT010993)
- mmu-miR-9-5p (MIRT015512)
- hsa-miR-130b-3p (MIRT020216)
- hsa-miR-103a-3p (MIRT027105)
- hsa-miR-19b-3p (MIRT031181)
- hsa-miR-205-5p (MIRT440936)
- hsa-miR-4473 (MIRT502727)
- hsa-miR-4671-3p (MIRT502728)
- hsa-miR-200b-5p (MIRT502729)
- hsa-miR-200a-5p (MIRT502730)
- hsa-miR-4517 (MIRT502731)
- hsa-miR-337-5p (MIRT502732)
- hsa-miR-4485-3p (MIRT502733)
- hsa-miR-559 (MIRT502734)
- hsa-miR-548y (MIRT502735)
- hsa-miR-548w (MIRT502736)
- hsa-miR-548o-5p (MIRT502737)
- hsa-miR-548j-5p (MIRT502738)
- hsa-miR-548i (MIRT502739)
- hsa-miR-548h-5p (MIRT502740)
- hsa-miR-548d-5p (MIRT502741)
- hsa-miR-548c-5p (MIRT502742)
- hsa-miR-548bb-5p (MIRT502743)
- hsa-miR-548b-5p (MIRT502744)
- hsa-miR-548ay-5p (MIRT502745)
- hsa-miR-548au-5p (MIRT502746)
- hsa-miR-548as-5p (MIRT502747)
- hsa-miR-548ar-5p (MIRT502748)
- hsa-miR-548aq-5p (MIRT502749)
- hsa-miR-548ap-5p (MIRT502750)
- hsa-miR-548am-5p (MIRT502751)
- hsa-miR-548ak (MIRT502752)
- hsa-miR-548ae-5p (MIRT502753)
- hsa-miR-548ad-5p (MIRT502754)
- hsa-miR-548ab (MIRT502755)
- hsa-miR-548a-5p (MIRT502756)
- hsa-miR-548n (MIRT502757)
- hsa-miR-454-3p (MIRT502758)
- hsa-miR-3666 (MIRT502759)
- hsa-miR-4295 (MIRT502760)
- hsa-miR-301b-3p (MIRT502761)
- hsa-miR-130a-3p (MIRT502762)
- hsa-miR-301a-3p (MIRT502763)
- hsa-miR-19a-3p (MIRT502764)
- hsa-miR-653-5p (MIRT538504)
- hsa-miR-3175 (MIRT538505)
- hsa-miR-4509 (MIRT538506)
- hsa-miR-6889-5p (MIRT538507)
- hsa-miR-6777-5p (MIRT538508)
- hsa-miR-6741-5p (MIRT558703)
- hsa-miR-340-5p (MIRT558704)
- hsa-miR-6748-5p (MIRT558705)
- hsa-miR-3944-5p (MIRT558706)
- hsa-miR-376a-2-5p (MIRT558707)
- hsa-miR-4286 (MIRT558708)
- hsa-miR-936 (MIRT558709)
- hsa-miR-6834-3p (MIRT558710)
- hsa-miR-3163 (MIRT558711)
- hsa-miR-140-3p (MIRT558712)
- hsa-miR-3662 (MIRT558713)
- hsa-miR-107 (MIRT558714)
- hsa-miR-5010-3p (MIRT704612)
- hsa-miR-2113 (MIRT704613)
- hsa-miR-8070 (MIRT704614)
- hsa-miR-4477a (MIRT704615)
- hsa-miR-3689f (MIRT704616)
- hsa-miR-3689e (MIRT704617)
- hsa-miR-3689b-5p (MIRT704618)
- hsa-miR-3689a-5p (MIRT704619)
- hsa-miR-4668-3p (MIRT704620)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLIP1
- Browse OriGene Inhibitory RNA Products For CLIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLIP1
Clone products for research
- Applied Biological Materials (abm): Clones for CLIP1 - Starting at $45 >
- * CLIP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CLIP1
- Addgene plasmids for CLIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLIP1
Cell Lines for research
-
Horizon Cell Lines for CLIP1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CLIP1 Gene
Localization for CLIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLIP1 Gene
- Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane. Peripheral membrane protein. Cytoplasmic side. Cell projection, ruffle. Note=Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698). {ECO:0000250 UniProtKB:Q922J3, ECO:0000269 PubMed:12433698, ECO:0000269 PubMed:17889670, ECO:0000269 PubMed:21646404}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (3)
- Microtubule ends (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | TAS | 15928712 |
| GO:0001726 | ruffle | IEA | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005813 | centrosome | IDA | 21399614 |
Pathways & Interactions for CLIP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle, Mitotic |
.83
|
.60
|
| 2 | Mitotic Metaphase and Anaphase |
.94
|
|
| 3 | Mitotic Prometaphase | ||
| 4 | Signaling by Rho GTPases | ||
| 5 | Cytoskeletal Signaling | ||
Pathways by source for CLIP1 Gene
2 BioSystems pathways for CLIP1 Gene
13 Reactome pathways for CLIP1 Gene
1 KEGG pathway for CLIP1 Gene
4 Qiagen pathways for CLIP1 Gene
- CDC42 Pathway
- Epithelial Adherens Junctions
- Remodeling of Adherens Junctions
- Rho Family GTPases
1 Cell Signaling Technology pathway for CLIP1 Gene
Interacting Proteins for CLIP1 Gene
Selected Interacting proteins:
P30622-CLIP1_HUMAN
ENSP00000479322
for CLIP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CLIP1
SIGNOR curated interactions for CLIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | TAS | 15928712 |
| GO:0001578 | microtubule bundle formation | IMP | 17889670 |
| GO:0031116 | positive regulation of microtubule polymerization | IBA,IMP | 15262990 |
| GO:0031122 | cytoplasmic microtubule organization | IBA | 21873635 |
Transcripts for CLIP1 Gene
mRNA/cDNA for CLIP1 Gene
- 4 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000302528 5833 nts (view in UCSC)
- ENST00000358808 5880 nts (view in UCSC)
- ENST00000361654 5568 nts (view in UCSC)
- ENST00000501271 2426 nts (view in UCSC)
- ENST00000514271 3493 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CLIP1 - Starting at $85 >
- * CLIP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CLIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLIP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLIP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLIP1
- Browse OriGene Inhibitory RNA Products For CLIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLIP1
Clone products for research
- Applied Biological Materials (abm): Clones for CLIP1 - Starting at $45 >
- * CLIP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CLIP1
- Addgene plasmids for CLIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLIP1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c | · | 27d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||
| SP9: |
Relevant External Links for CLIP1 Gene
- GeneLoc Exon Structure for
- CLIP1
Expression for CLIP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CLIP1 Gene
This gene is overexpressed in Muscle - Skeletal (x8.4).
This gene is overexpressed in Peripheral blood mononuclear cells (15.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CLIP1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLIP1
SOURCE GeneReport for Unigene cluster for CLIP1 Gene:
Hs.524809mRNA Expression by UniProt/SwissProt for CLIP1 Gene:
P30622-CLIP1_HUMAN
Tissue specificity:
Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.
Evidence on tissue expression from TISSUES for CLIP1 Gene
- Blood(4.5)
- Liver(4.5)
- Intestine(4.4)
- Nervous system(3.9)
- Muscle(3)
- Kidney(2.7)
- Skin(2.7)
- Heart(2.6)
- Lung(2.2)
- Eye(2.1)
- Thyroid gland(2)
- Spleen(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CLIP1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- pharynx
- skull
- tooth
Thorax:
- chest wall
- heart
Abdomen:
- abdominal wall
Limb:
- foot
- lower limb
General:
- blood vessel
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
Primer products for research
-
OriGene qPCR primer pairs for CLIP1
-
OriGene qPCR primer pairs and template standards for CLIP1
Gene Expression Assays for research
Orthologs for CLIP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CLIP1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | CLIP1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CLIP1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Clip1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CLIP1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CLIP1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CLIP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | clip1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CLIP1 (2 of 2) 31 |
|
OneToMany | |
| clip1a 30 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CLIP-190 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for CLIP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CLIP1 Gene
- ENSEMBL:
- Gene Tree for CLIP1 (if available)
- TreeFam:
- Gene Tree for CLIP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CLIP1: view image
Paralogs for CLIP1 Gene
(6) SIMAP similar genes for CLIP1 Gene using alignment to 11 proteins:
- CLIP1_HUMAN
- F5H0N7_HUMAN
- F5H1T5_HUMAN
- F5H270_HUMAN
- F5H367_HUMAN
- F5H6A0_HUMAN
- F5H6H4_HUMAN
- F6VGP8_HUMAN
- J3KP58_HUMAN
- Q6P5Z9_HUMAN
- Q86WU4_HUMAN
Variants for CLIP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLIP1 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 839306 | Uncertain Significance: not provided | 122,355,294(-) |
G/A NM_002956.2(CLIP1):c.1024C>T (p.Arg342Cys) |
MISSENSE | |
| 978177 | Uncertain Significance: Global developmental delay | 122,273,074(-) |
T/C NM_002956.3(CLIP1):c.4085A>G (p.Lys1362Arg) |
MISSENSE | |
| rs1012699618 | Likely Benign: not provided | 122,341,620(-) |
C/T NM_002956.2(CLIP1):c.1551G>A (p.Glu517=) |
SYNONYMOUS | |
| rs115643125 | Benign: not provided | 122,361,061(-) |
C/T NM_002956.2(CLIP1):c.903G>A (p.Ala301=) |
SYNONYMOUS | |
| rs115820623 | Benign: not provided | 122,377,740(-) |
C/T NM_002956.2(CLIP1):c.306G>A (p.Ser102=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv324e199 | CNV | deletion | 23128226 |
| esv2672169 | CNV | deletion | 23128226 |
| esv3630973 | CNV | gain | 21293372 |
| esv3630974 | CNV | loss | 21293372 |
| esv3630975 | CNV | loss | 21293372 |
| nsv1138177 | CNV | deletion | 24896259 |
| nsv1138178 | CNV | deletion | 24896259 |
| nsv476982 | CNV | novel sequence insertion | 20440878 |
| nsv973131 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
4.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
19.86;
98.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLIP1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIP1 Gene
Disorders for CLIP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| autosomal recessive non-syndromic intellectual disability |
|
|
| perry syndrome |
|
|
| lissencephaly |
|
|
| neuronopathy, distal hereditary motor, type viib |
|
|
| distal hereditary motor neuronopathy type 7 |
|
|
Search CLIP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CLIP1
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CLIP1 Gene
Publications for CLIP1 Gene
- Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. (PMID: 17563362) Mishima M … Hakoshima T (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 23
- Structure-function relationship of CAP-Gly domains. (PMID: 17828277) Weisbrich A … Steinmetz MO (Nature structural & molecular biology 2007) 3 4 23
- The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. (PMID: 12231510) Choi JH … Zheng XF (EMBO reports 2002) 3 4 23
- Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus. (PMID: 8222754) Hilliker C … Van den Berghe H (Cytogenetics and cell genetics 1994) 2 3 23
- SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. (PMID: 21646404) van der Vaart B … Akhmanova A (The Journal of cell biology 2011) 3 4
ExternalLinks
Products for CLIP1 Gene
- Custom Antibody ServicesOriGene Antibodies for CLIP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CLIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for CLIP1
- Origene Custom Protein Services for CLIP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLIP1
- Browse OriGene Inhibitory RNA Products For CLIP1
- OriGene qPCR primer pairs for CLIP1
- OriGene qPCR primer pairs and template standards for CLIP1
- OriGene CRISPR knockouts for CLIP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CLIP1
- Sino Biological Human cDNA Clone for CLIP1
- Browse Sino Biological Recombinant Proteins
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- Sino Biological Antibodies for CLIP1
- Browse Sino Biological Assays
- Browse Antibodies
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins for CLIP1
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- Browse Primary Antibodies
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- Invitrogen Antibodies for CLIP1 (AFLGC-CLIP1)
- VectorBuilder Custom and pre-made DNA vectors for CLIP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CLIP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CLIP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CLIP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CLIP1
- Addgene plasmids for CLIP1
- antibodies-online: Show 41 available CLIP1 Antibodies ranked by validation data
- Compare Top CLIP1 Antibodies
- antibodies-online: Search results for available CLIP1 related products ranked by validation data
- antibodies-online: Search results for available CLIP1 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for CLIP1
- Search Santa Cruz Biotechnology (SCBT) for CLIP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CLIP1
- Horizon Cell Lines for CLIP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLIP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CLIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLIP1
Sources for CLIP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB