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The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
CLIP1 (CAP-Gly Domain Containing Linker Protein 1) is a Protein Coding gene. Diseases associated with CLIP1 include Autosomal Recessive Non-Syndromic Intellectual Disability and Subserous Uterine Fibroid. Among its related pathways are Signaling by GPCR and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and microtubule binding. An important paralog of this gene is CLIP2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 11940666 |
GO:0008017 | microtubule binding | IEA,IDA | 17889670 |
GO:0008270 | zinc ion binding | IDA | 17828275 |
GO:0015631 | tubulin binding | IDA | 17889670 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000776 | kinetochore | TAS | 15928712 |
GO:0001726 | ruffle | IEA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005635 | nuclear envelope | IEA | -- |
GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Mitotic Metaphase and Anaphase |
.94
|
|
3 | Mitotic Prometaphase | ||
4 | Signaling by Rho GTPases | ||
5 | Cytoskeletal Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | TAS | 15928712 |
GO:0001578 | microtubule bundle formation | IMP | 17889670 |
GO:0031116 | positive regulation of microtubule polymerization | IMP | 15262990 |
GO:0031122 | cytoplasmic microtubule organization | IBA | 21873635 |
GO:0044861 | protein transport into plasma membrane raft | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c | · | 27d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CLIP1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | CLIP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CLIP1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Clip1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CLIP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CLIP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CLIP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | clip1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CLIP1 (2 of 2) 31 |
|
OneToMany | |
clip1a 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CLIP-190 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708546 | Benign: not provided | 122,361,061(-) | C/T | SYNONYMOUS_VARIANT | |
711098 | Likely Benign: not provided | 122,377,442(-) | C/G | MISSENSE_VARIANT | |
717357 | Benign: not provided | 122,278,196(-) | T/C | SYNONYMOUS_VARIANT | |
721639 | Benign: not provided | 122,328,016(-) | G/A | SYNONYMOUS_VARIANT | |
726068 | Benign: not provided | 122,364,054(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv324e199 | CNV | deletion | 23128226 |
esv2672169 | CNV | deletion | 23128226 |
esv3630973 | CNV | gain | 21293372 |
esv3630974 | CNV | loss | 21293372 |
esv3630975 | CNV | loss | 21293372 |
nsv1138177 | CNV | deletion | 24896259 |
nsv1138178 | CNV | deletion | 24896259 |
nsv476982 | CNV | novel sequence insertion | 20440878 |
nsv973131 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
autosomal recessive non-syndromic intellectual disability |
|
|
subserous uterine fibroid |
|
|
extratemporal epilepsy |
|
|
perry syndrome |
|
|
lissencephaly |
|
|