Aliases for CLINT1 Gene
External Ids for CLINT1 Gene
Previous GeneCards Identifiers for CLINT1 Gene
This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
GeneCards Summary for CLINT1 Gene
CLINT1 (Clathrin Interactor 1) is a Protein Coding gene. Diseases associated with CLINT1 include Schizophrenia and Cataract 8, Multiple Types. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include lipid binding and clathrin binding. An important paralog of this gene is EPN3.
UniProtKB/Swiss-Prot for CLINT1 Gene
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.