Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tiss... See more...

Aliases for CLIC4 Gene

Aliases for CLIC4 Gene

  • Chloride Intracellular Channel 4 2 3 5
  • P64H1 2 2 3
  • Intracellular Chloride Ion Channel Protein P64H1 3 4
  • Chloride Intracellular Channel Protein 4 3 4
  • CLIC4L 2 3
  • HuH1 2 3
  • H1 2 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Chloride Intracellular Channel 4 Like 3
  • DKFZP566G223 2
  • MTCLIC 3
  • CLIC4 5

External Ids for CLIC4 Gene

Previous GeneCards Identifiers for CLIC4 Gene

  • GC01P024596
  • GC01P024141
  • GC01P024423
  • GC01P024817
  • GC01P024944
  • GC01P025071
  • GC01P023328

Summaries for CLIC4 Gene

Entrez Gene Summary for CLIC4 Gene

  • Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

GeneCards Summary for CLIC4 Gene

CLIC4 (Chloride Intracellular Channel 4) is a Protein Coding gene. Diseases associated with CLIC4 include Hemochromatosis Type 2. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC6.

UniProtKB/Swiss-Prot Summary for CLIC4 Gene

  • Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Gene Wiki entry for CLIC4 Gene

Additional gene information for CLIC4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLIC4 Gene

Genomics for CLIC4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CLIC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J024740 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 610.4 +0.1 68 9.7 CEBPG SP1 ATF7 TEAD4 PRDM10 ZNF629 LEF1 IKZF1 KDM1A ZNF692 CLIC4 MG828430 SRSF10 SRRM1 ENSG00000261349 FUCA1 SYF2 PNRC2 lnc-SRRM1-3 RUNX3
GH01J024712 Enhancer 0.9 Ensembl ENCODE dbSUPER 22.1 -31.1 -31098 3.4 HNRNPL USF2 EGR1 CEBPB ZNF316 FOS JUND ZFHX2 FOSL2 MAFK CLIC4 RNU6-1208P SRRM1 piR-58297-004 ENSG00000284699
GH01J024765 Enhancer 1.1 ENCODE dbSUPER 12.2 +20.4 20350 1.2 PRDM10 LEF1 IKZF1 JUND DDX20 MTA2 MTA1 NR2C1 ZNF24 ZNF740 SRSF10 SRRM1 CLIC4 PNRC2 NCMAP lnc-SRRM1-3 RUNX3
GH01J024682 Enhancer 1 Ensembl ENCODE dbSUPER 12.5 -61.8 -61830 2.1 JUND DPF2 ZNF600 SP1 HMBOX1 NR3C1 FOS JUN FOSL1 FOSL2 HSALNG0001732 CLIC4 RNU6-1208P NCMAP piR-59928-002 SRRM1
GH01J024704 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.4 -39.9 -39887 2.4 SP1 GATAD2A PRDM10 ZNF629 ZNF512 SOX13 RCOR2 JUND FOXA1 PRDM1 ENSG00000284699 NCMAP CLIC4 piR-58297-004 SRRM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLIC4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLIC4

Top Transcription factor binding sites by QIAGEN in the CLIC4 gene promoter:
  • C/EBPbeta
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO3a
  • FOXO3b
  • Pax-5
  • S8
  • Zic1

Genomic Locations for CLIC4 Gene

Genomic Locations for CLIC4 Gene
chr1:24,745,382-24,844,321
(GRCh38/hg38)
Size:
98,940 bases
Orientation:
Plus strand
chr1:25,071,760-25,170,815
(GRCh37/hg19)
Size:
99,056 bases
Orientation:
Plus strand

Genomic View for CLIC4 Gene

Genes around CLIC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLIC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLIC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIC4 Gene

Proteins for CLIC4 Gene

  • Protein details for CLIC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y696-CLIC4_HUMAN
    Recommended name:
    Chloride intracellular channel protein 4
    Protein Accession:
    Q9Y696
    Secondary Accessions:
    • Q9UFW9
    • Q9UQJ6

    Protein attributes for CLIC4 Gene

    Size:
    253 amino acids
    Molecular mass:
    28772 Da
    Quaternary structure:
    • Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9.

    Three dimensional structures from OCA and Proteopedia for CLIC4 Gene

neXtProt entry for CLIC4 Gene

Post-translational modifications for CLIC4 Gene

  • Ubiquitination at Lys11, Lys62, Lys130, Lys146, Lys199, and Lys212
  • Modification sites at PhosphoSitePlus

Other Protein References for CLIC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLIC4 Gene

Domains & Families for CLIC4 Gene

Gene Families for CLIC4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for CLIC4 Gene

InterPro:
Blocks:
  • Intracellular chloride (Cl-) channel signature
ProtoNet:

Suggested Antigen Peptide Sequences for CLIC4 Gene

GenScript: Design optimal peptide antigens:
  • Intracellular chloride ion channel protein p64H1 (CLIC4_HUMAN)
  • cDNA, FLJ96000, Homo sapiens chloride intracellular channel 4 (CLIC4), mRNA (Q6FIC5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y696

UniProtKB/Swiss-Prot:

CLIC4_HUMAN :
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • Belongs to the chloride channel CLIC family.
Domain:
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
Family:
  • Belongs to the chloride channel CLIC family.
genes like me logo Genes that share domains with CLIC4: view

Function for CLIC4 Gene

Molecular function for CLIC4 Gene

UniProtKB/Swiss-Prot Function:
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
UniProtKB/Swiss-Prot Induction:
Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts.

Phenotypes From GWAS Catalog for CLIC4 Gene

Gene Ontology (GO) - Molecular Function for CLIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005254 chloride channel activity IBA 21873635
GO:0005515 protein binding IPI 10793131
genes like me logo Genes that share ontologies with CLIC4: view
genes like me logo Genes that share phenotypes with CLIC4: view

Animal Models for CLIC4 Gene

MGI Knock Outs for CLIC4:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLIC4

CRISPR Products

miRNA for CLIC4 Gene

miRTarBase miRNAs that target CLIC4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLIC4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLIC4 Gene

Localization for CLIC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIC4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane. Single-pass membrane protein. Nucleus matrix. Cell membrane. Single-pass membrane protein. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLIC4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
extracellular 4
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CLIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005623 cell IEA --
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA,IDA 10793131
GO:0005739 mitochondrion IBA,IDA 14569596
genes like me logo Genes that share ontologies with CLIC4: view

Pathways & Interactions for CLIC4 Gene

PathCards logo

SuperPathways for CLIC4 Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
.77
.77
.56
2 Glucose / Energy Metabolism
3 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.40
4 Hepatic ABC Transporters
.41
genes like me logo Genes that share pathways with CLIC4: view

Pathways by source for CLIC4 Gene

5 Qiagen pathways for CLIC4 Gene
  • Activation of cAMP-Dependent PKA
  • cAMP Pathway
  • Cholera Infection
  • Hepatic ABC Transporters
  • PKA Signaling
1 Cell Signaling Technology pathway for CLIC4 Gene

Gene Ontology (GO) - Biological Process for CLIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IBA 21873635
GO:0001886 endothelial cell morphogenesis IEA --
GO:0006811 ion transport IEA --
GO:0006821 chloride transport NAS 10793131
GO:0007035 vacuolar acidification IEA --
genes like me logo Genes that share ontologies with CLIC4: view

No data available for SIGNOR curated interactions for CLIC4 Gene

Drugs & Compounds for CLIC4 Gene

(1) Drugs for CLIC4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloride ion Experimental Pharma 0

(1) Additional Compounds for CLIC4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLIC4: view

Transcripts for CLIC4 Gene

mRNA/cDNA for CLIC4 Gene

1 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLIC4

Alternative Splicing Database (ASD) splice patterns (SP) for CLIC4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: - -

Relevant External Links for CLIC4 Gene

GeneLoc Exon Structure for
CLIC4

Expression for CLIC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLIC4 Gene

mRNA differential expression in normal tissues according to GTEx for CLIC4 Gene

This gene is overexpressed in Artery - Tibial (x5.1) and Artery - Aorta (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CLIC4 Gene



Protein tissue co-expression partners for CLIC4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLIC4

SOURCE GeneReport for Unigene cluster for CLIC4 Gene:

Hs.440544

mRNA Expression by UniProt/SwissProt for CLIC4 Gene:

Q9Y696-CLIC4_HUMAN
Tissue specificity: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.

Evidence on tissue expression from TISSUES for CLIC4 Gene

  • Nervous system(4.9)
  • Kidney(4.8)
  • Liver(4.6)
  • Blood(4.4)
  • Skin(3.6)
  • Heart(3.4)
  • Lung(3.3)
  • Muscle(3)
  • Intestine(2.7)
  • Spleen(2.6)
  • Lymph node(2.3)
  • Gall bladder(2.2)
  • Stomach(2.1)
  • Adrenal gland(2.1)
  • Bone(2.1)
  • Pancreas(2)
  • Eye(2)
genes like me logo Genes that share expression patterns with CLIC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLIC4 Gene

Orthologs for CLIC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLIC4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CLIC4 30 31
  • 99.87 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CLIC4 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CLIC4 30 31
  • 95.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CLIC4 30 31
  • 94.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Clic4 30
  • 88.93 (n)
Mouse
(Mus musculus)
Mammalia Clic4 30 17 31
  • 88.41 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CLIC4 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CLIC4 30 31
  • 78.4 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CLIC4 31
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia clic5 30
  • 76.46 (n)
Str.20225 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.3485 30
Zebrafish
(Danio rerio)
Actinopterygii clic4 30 31
  • 75 (n)
OneToOne
wufc47b04 30
Fruit Fly
(Drosophila melanogaster)
Insecta Clic 31
  • 26 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea exl-1 31
  • 25 (a)
ManyToMany
exc-4 31
  • 21 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6991 31
  • 46 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2986 30
Species where no ortholog for CLIC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CLIC4 Gene

ENSEMBL:
Gene Tree for CLIC4 (if available)
TreeFam:
Gene Tree for CLIC4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLIC4: view image

Paralogs for CLIC4 Gene

(6) SIMAP similar genes for CLIC4 Gene using alignment to 2 proteins:

  • CLIC4_HUMAN
  • Q6FIC5_HUMAN

Pseudogenes.org Pseudogenes for CLIC4 Gene

genes like me logo Genes that share paralogs with CLIC4: view

Variants for CLIC4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLIC4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1557810606 Likely Pathogenic: Short stature 24,814,131(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CLIC4 Gene

Structural Variations from Database of Genomic Variants (DGV) for CLIC4 Gene

Variant ID Type Subtype PubMed ID
dgv2n73 CNV deletion 24416366
dgv63n106 CNV deletion 24896259
esv1446144 CNV deletion 17803354
esv2082154 CNV deletion 18987734
esv2525447 CNV deletion 19546169
esv2745530 CNV deletion 23290073
esv3559454 CNV deletion 23714750
esv3585512 CNV loss 21293372
esv3585513 CNV loss 21293372
esv3585514 CNV loss 21293372
esv3809 CNV loss 18987735
esv7429 CNV loss 19470904
esv995045 CNV deletion 20482838
esv995974 CNV deletion 20482838
nsv1002864 CNV loss 25217958
nsv1014245 CNV gain 25217958
nsv1076284 CNV deletion 25765185
nsv1113090 CNV deletion 24896259
nsv1121757 CNV deletion 24896259
nsv1151632 CNV deletion 26484159
nsv160319 CNV deletion 16902084
nsv498666 CNV loss 21111241
nsv511684 CNV loss 21212237
nsv522437 CNV gain 19592680
nsv7076 CNV deletion 18451855
nsv945829 CNV duplication 23825009

Variation tolerance for CLIC4 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLIC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLIC4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIC4 Gene

Disorders for CLIC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLIC4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemochromatosis type 2
  • hfe2
- elite association - COSMIC cancer census association via MalaCards
Search CLIC4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CLIC4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CLIC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLIC4 Gene

Publications for CLIC4 Gene

  1. Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro. (PMID: 19247789) Tung JJ … Kitajewski J (Angiogenesis 2009) 3 4 23
  2. Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. (PMID: 17200346) Suh KS … Yuspa SH (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 4 23
  3. Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis. (PMID: 16239224) Bohman S … Claesson-Welsh L (The Journal of biological chemistry 2005) 3 4 23
  4. Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts. (PMID: 12163372) Rønnov-Jessen L … Petersen OW (The American journal of pathology 2002) 3 4 23
  5. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (PMID: 10793131) Berryman M … Bretscher A (Molecular biology of the cell 2000) 3 4 23

Products for CLIC4 Gene

Sources for CLIC4 Gene