External Ids for CLIC3 Gene
Previous GeneCards Identifiers for CLIC3 Gene
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLIC3 Gene
CLIC3 (Chloride Intracellular Channel 3) is a Protein Coding gene. Diseases associated with CLIC3 include Deafness, Autosomal Recessive 33. Among its related pathways are Activation of cAMP-Dependent PKA and Hepatic ABC Transporters. Gene Ontology (GO) annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC1.
UniProtKB/Swiss-Prot for CLIC3 Gene
Can insert into membranes and form chloride ion channels. May participate in cellular growth control.