External Ids for CLGN Gene
Previous GeneCards Identifiers for CLGN Gene
Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLGN Gene
CLGN (Calmegin) is a Protein Coding gene. Diseases associated with CLGN include Colloid Adenoma and Carotid Artery Dissection. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein binding involved in protein folding. An important paralog of this gene is CANX.
UniProtKB/Swiss-Prot Summary for CLGN Gene
Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).