Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLECL1 Gene

Aliases for CLECL1 Gene

  • C-Type Lectin Like 1 2 3 5
  • Dendritic Cell-Associated Lectin 1 3 4
  • DC-Associated Lectin-1 3 4
  • DCAL-1 3 4
  • DCAL1 3 4
  • Type II Transmembrane Protein DCAL1 3
  • Dendritic Cell Associated Lectin 1 2
  • C-Type Lectin-Like Domain Family 1 3
  • C-Type Lectin-Like 1 2

External Ids for CLECL1 Gene

Previous GeneCards Identifiers for CLECL1 Gene

  • GC12M009767
  • GC12M009875
  • GC12M009618
  • GC12M009964
  • GC12M010063
  • GC12M010257
  • GC12M010499
  • GC12M009807
  • GC12M010164
  • GC12M010759
  • GC12M010992
  • GC12M011289
  • GC12M011524
  • GC12M011718

Summaries for CLECL1 Gene

Entrez Gene Summary for CLECL1 Gene

  • This gene encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B cells. This protein may act as a T-cell costimulatory molecule that enhances interleukin-4 production, and maybe involved in the regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for CLECL1 Gene

CLECL1 (C-Type Lectin Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding.

UniProtKB/Swiss-Prot for CLECL1 Gene

  • May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.

Additional gene information for CLECL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLECL1 Gene

Genomics for CLECL1 Gene

GeneHancer (GH) Regulatory Elements for CLECL1 Gene

Promoters and enhancers for CLECL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I009720 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 588.6 +6.1 6087 13.1 PKNOX1 FOXA2 IRF4 ATF7 FOS RUNX3 JUNB REST SMARCA4 NBN CLECL1 KLRB1 ENSG00000213443 ENSG00000257027 OLR1 CLEC12A CD69 CLEC7A LINC02367 LOC374443
GH12I009756 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.5 -28.0 -27980 10 HDGF PKNOX1 ATF1 SMAD1 ARNT IRF4 TCF12 POLR2B GATA2 ATF7 CD69 CLECL1 KLRF1 CLEC7A OLR1 KLRB1 CLEC12A ENSG00000213443 DDX12P PZP
GH12I009701 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 33 +30.8 30751 2.2 ZFP64 ZC3H11A EBF1 ZNF781 ZNF518A ZNF697 ZNF555 ZFHX2 RUNX3 EGR2 LINC02390 CLECL1 PHC1 CLEC2D KLRA1P LOC642846 KLRB1 DDX12P LINC00612 ENSG00000213443
GH12I009646 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 17 +81.6 81566 10 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 IRF4 SLC30A9 ZNF207 ZNF143 LOC105369728 CLEC2D LOC374443 DDX12P KLRB1 CLECL1 CLEC7A M6PR CLEC12A LOC642846
GH12I009707 Enhancer 1 Ensembl ENCODE dbSUPER 30.3 +25.1 25054 1.6 CTCF ZNF654 TRIM22 OVOL3 REST EBF1 RAD21 ZNF316 POLR2A ZNF585B CLECL1 PHC1 KLRA1P KLRB1 MAGOHB LOC374443 LINC02390 GC12P009754
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLECL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLECL1 gene promoter:

Genomic Locations for CLECL1 Gene

Genomic Locations for CLECL1 Gene
chr12:9,715,860-9,733,299
(GRCh38/hg38)
Size:
17,440 bases
Orientation:
Minus strand
chr12:9,868,456-9,885,895
(GRCh37/hg19)

Genomic View for CLECL1 Gene

Genes around CLECL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLECL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLECL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLECL1 Gene

Proteins for CLECL1 Gene

  • Protein details for CLECL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZS7-CLCL1_HUMAN
    Recommended name:
    C-type lectin-like domain family 1
    Protein Accession:
    Q8IZS7

    Protein attributes for CLECL1 Gene

    Size:
    167 amino acids
    Molecular mass:
    19115 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLECL1 Gene

Post-translational modifications for CLECL1 Gene

  • Glycosylation at posLast=109109, Asn140, and Asn149
  • Modification sites at PhosphoSitePlus

Other Protein References for CLECL1 Gene

No data available for DME Specific Peptides for CLECL1 Gene

Domains & Families for CLECL1 Gene

Gene Families for CLECL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CLECL1 Gene

Suggested Antigen Peptide Sequences for CLECL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLECL1: view

No data available for UniProtKB/Swiss-Prot for CLECL1 Gene

Function for CLECL1 Gene

Molecular function for CLECL1 Gene

UniProtKB/Swiss-Prot Function:
May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.

Phenotypes From GWAS Catalog for CLECL1 Gene

Gene Ontology (GO) - Molecular Function for CLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLECL1: view
genes like me logo Genes that share phenotypes with CLECL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLECL1 Gene

Localization for CLECL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLECL1 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLECL1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,IEA 12421943
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLECL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLECL1 Gene

Pathways & Interactions for CLECL1 Gene

SuperPathways for CLECL1 Gene

No Data Available

Interacting Proteins for CLECL1 Gene

Gene Ontology (GO) - Biological Process for CLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042102 positive regulation of T cell proliferation IDA 12421943
GO:0072602 interleukin-4 secretion IDA 12421943
GO:0097323 B cell adhesion IDA 12421943
genes like me logo Genes that share ontologies with CLECL1: view

No data available for Pathways by source and SIGNOR curated interactions for CLECL1 Gene

Drugs & Compounds for CLECL1 Gene

No Compound Related Data Available

Transcripts for CLECL1 Gene

mRNA/cDNA for CLECL1 Gene

Unigene Clusters for CLECL1 Gene

C-type lectin-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLECL1 Gene

No ASD Table

Relevant External Links for CLECL1 Gene

GeneLoc Exon Structure for
CLECL1
ECgene alternative splicing isoforms for
CLECL1

Expression for CLECL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLECL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLECL1 Gene

This gene is overexpressed in Spleen (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLECL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CLECL1 Gene:

CLECL1

SOURCE GeneReport for Unigene cluster for CLECL1 Gene:

Hs.560087

mRNA Expression by UniProt/SwissProt for CLECL1 Gene:

Q8IZS7-CLCL1_HUMAN
Tissue specificity: Expressed in spleen, lymph node, and tonsil. Lower expression in peripheral blood, bone marrow, and colon. No expression detected in thymus. Highly expressed in dendritic and B-cells.

Evidence on tissue expression from TISSUES for CLECL1 Gene

  • Nervous system(4)
  • Eye(2.5)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with CLECL1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLECL1 Gene

Orthologs for CLECL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLECL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLECL1 33 34
  • 98.43 (n)
cow
(Bos Taurus)
Mammalia CLECL1 34
  • 18 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 18 (a)
OneToMany
-- 34
  • 18 (a)
OneToMany
-- 34
  • 14 (a)
OneToMany
-- 34
  • 13 (a)
OneToMany
Species where no ortholog for CLECL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLECL1 Gene

ENSEMBL:
Gene Tree for CLECL1 (if available)
TreeFam:
Gene Tree for CLECL1 (if available)

Paralogs for CLECL1 Gene

No data available for Paralogs for CLECL1 Gene

Variants for CLECL1 Gene

Sequence variations from dbSNP and Humsavar for CLECL1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000348866 -- 9,717,678(-) AAAAA/AA genic_downstream_transcript_variant, intron_variant
rs1000373077 -- 9,722,481(-) C/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000458688 -- 9,729,676(-) T/A/G intron_variant
rs1000584139 -- 9,724,706(-) A/G intron_variant
rs1000707667 -- 9,730,865(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLECL1 Gene

Variant ID Type Subtype PubMed ID
esv2651553 CNV insertion 19546169
esv2759878 CNV gain+loss 17122850
esv3443832 CNV insertion 20981092
esv3628513 CNV loss 21293372
esv3628514 CNV gain 21293372
nsv1051530 CNV gain 25217958
nsv442255 CNV loss 18776908
nsv8910 CNV gain 18304495

Variation tolerance for CLECL1 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLECL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLECL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLECL1 Gene

Disorders for CLECL1 Gene

Additional Disease Information for CLECL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CLECL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLECL1 Gene

Publications for CLECL1 Gene

  1. Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4. (PMID: 12421943) Ryan EJ … Clark EA (Journal of immunology (Baltimore, Md. : 1950) 2002) 2 3 4 22 58
  2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 44 58
  3. Ligation of dendritic cell-associated lectin-1 induces partial maturation of human monocyte derived dendritic cells. (PMID: 19027044) Ryan EJ … Clark EA (Human immunology 2009) 3 22 58
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 58
  5. Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia. (PMID: 19648166) Zhao X … Korver W (Haematologica 2010) 3 58

Products for CLECL1 Gene

Sources for CLECL1 Gene

Content
Loading form....