Aliases for CLEC6A Gene
External Ids for CLEC6A Gene
Previous HGNC Symbols for CLEC6A Gene
Previous GeneCards Identifiers for CLEC6A Gene
The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for CLEC6A Gene
CLEC6A (C-Type Lectin Domain Containing 6A) is a Protein Coding gene. Diseases associated with CLEC6A include Cryptococcosis and Opportunistic Mycosis. Among its related pathways are CLEC7A (Dectin-1) signaling and Defective GALNT12 causes colorectal cancer 1 (CRCS1). Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC4C.
UniProtKB/Swiss-Prot Summary for CLEC6A Gene
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner (PubMed:28652405). Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).