Aliases for CLEC4G Gene
External Ids for CLEC4G Gene
Previous GeneCards Identifiers for CLEC4G Gene
This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]
GeneCards Summary for CLEC4G Gene
CLEC4G (C-Type Lectin Domain Family 4 Member G) is a Protein Coding gene. Diseases associated with CLEC4G include Lymphocytic Choriomeningitis and Japanese Encephalitis. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is FCER2.
UniProtKB/Swiss-Prot Summary for CLEC4G Gene
Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.
(Microbial infection) Acts as a receptor for Japanese encephalitis virus.
(Microbial infection) Acts as a receptor for Ebolavirus.
(Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV.
(Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).