This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functi... See more...

Aliases for CLEC4G Gene

Aliases for CLEC4G Gene

  • C-Type Lectin Domain Family 4 Member G 2 3 4 5
  • LSECtin 2 3 4
  • Liver And Lymph Node Sinusoidal Endothelial Cell C-Type Lectin 3 4
  • C-Type Lectin Superfamily 4, Member G 2 3
  • UNQ431 2 3
  • C-Type Lectin Domain Family 4, Member G 2
  • DTTR431 3
  • LP2698 3
  • CLEC4G 5

External Ids for CLEC4G Gene

Previous GeneCards Identifiers for CLEC4G Gene

  • GC19M007703
  • GC19M007463
  • GC19M007793

Summaries for CLEC4G Gene

Entrez Gene Summary for CLEC4G Gene

  • This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

GeneCards Summary for CLEC4G Gene

CLEC4G (C-Type Lectin Domain Family 4 Member G) is a Protein Coding gene. Diseases associated with CLEC4G include Lymphocytic Choriomeningitis and Japanese Encephalitis. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is FCER2.

UniProtKB/Swiss-Prot Summary for CLEC4G Gene

  • Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.
  • (Microbial infection) Acts as a receptor for Japanese encephalitis virus.
  • (Microbial infection) Acts as a receptor for Ebolavirus.
  • (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV.
  • (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).

Additional gene information for CLEC4G Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLEC4G Gene

Genomics for CLEC4G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CLEC4G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007734 Promoter 0.6 Ensembl 609.8 -0.6 -595 0.2 CEBPA SCRT2 CEBPB CEBPG HLF CLEC4G HSALNG0123670 CD209
GH19J007732 Promoter 0.3 EPDnew 600.7 +1.8 1778 0.1 CLEC4G lnc-CD209-1 RF00017-2790 FCER2
GH19J007700 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.4 +29.4 29418 7 SP1 IKZF1 KDM1A POLR2A BACH1 LARP7 STAT3 ZNF143 RELA ZIC2 FCER2 STXBP2 ELAVL1 HNRNPM XAB2 PEX11G MAP2K7 CD209 CLEC4G RPL21P129
GH19J007807 Enhancer 1.1 Ensembl ENCODE 11.6 -74.0 -74018 2.2 SP1 TEAD4 ZNF629 BACH1 JUND STAT3 RELA TCF12 IKZF2 TRIM22 ELAVL1 HNRNPM XAB2 ZNF557 ZNF414 MAP2K7 TRAPPC5 MCEMP1 RPL21P129 CD209
GH19J007616 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.9 +115.3 115268 4.5 ZNF300 ZNF776 RBFOX2 SP1 ZNF341 SCRT2 ZFX SP2 ZNF157 ZIK1 MIR6792 XAB2 ELAVL1 HNRNPM PET100 PCP2 CAMSAP3 ZNF414 CLEC4G MAP2K7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC4G on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLEC4G

Top Transcription factor binding sites by QIAGEN in the CLEC4G gene promoter:
  • ARP-1
  • FOXO1
  • FOXO1a
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • RFX1
  • RP58

Genomic Locations for CLEC4G Gene

Genomic Locations for CLEC4G Gene
chr19:7,728,957-7,733,906
(GRCh38/hg38)
Size:
4,950 bases
Orientation:
Minus strand
chr19:7,793,843-7,798,792
(GRCh37/hg19)
Size:
4,950 bases
Orientation:
Minus strand

Genomic View for CLEC4G Gene

Genes around CLEC4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC4G Gene

Proteins for CLEC4G Gene

  • Protein details for CLEC4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXB4-CLC4G_HUMAN
    Recommended name:
    C-type lectin domain family 4 member G
    Protein Accession:
    Q6UXB4

    Protein attributes for CLEC4G Gene

    Size:
    293 amino acids
    Molecular mass:
    32562 Da
    Quaternary structure:
    • (Microbial infection) Interacts with Japanese encephalitis virus envelope protein E.
    • (Microbial infection) Interacts with ebolavirus glycoprotein.
    • (Microbial infection) Interacts with SARS coronavirus/SARS-CoV spike glycoprotein.
    • (Microbial infection) Interacts with lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).

neXtProt entry for CLEC4G Gene

Post-translational modifications for CLEC4G Gene

  • Glycosylation at Asn73 and Asn159
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC4G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC4G Gene

Domains & Families for CLEC4G Gene

Gene Families for CLEC4G Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLEC4G Gene

InterPro:
Blocks:
  • Type II antifreeze protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for CLEC4G Gene

GenScript: Design optimal peptide antigens:
  • CLEC4G protein (B7ZKQ2_HUMAN)
  • C-type lectin domain family 4 member G (CLC4G_HUMAN)
genes like me logo Genes that share domains with CLEC4G: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CLEC4G Gene

Function for CLEC4G Gene

Molecular function for CLEC4G Gene

UniProtKB/Swiss-Prot Function:
Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Japanese encephalitis virus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Ebolavirus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).

Phenotypes From GWAS Catalog for CLEC4G Gene

Gene Ontology (GO) - Molecular Function for CLEC4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 18624398
GO:0030246 carbohydrate binding IEA --
GO:0030247 polysaccharide binding IEA --
genes like me logo Genes that share ontologies with CLEC4G: view
genes like me logo Genes that share phenotypes with CLEC4G: view

Animal Models for CLEC4G Gene

MGI Knock Outs for CLEC4G:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC4G

CRISPR Products

miRNA for CLEC4G Gene

miRTarBase miRNAs that target CLEC4G

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC4G

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC4G Gene

Localization for CLEC4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC4G Gene

Cell membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC4G gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for CLEC4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC4G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC4G Gene

Pathways & Interactions for CLEC4G Gene

PathCards logo

SuperPathways for CLEC4G Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLEC4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002710 negative regulation of T cell mediated immunity IEA --
GO:0016032 viral process IEA --
GO:0042130 negative regulation of T cell proliferation IEA --
GO:0046718 viral entry into host cell IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CLEC4G: view

No data available for Pathways by source and SIGNOR curated interactions for CLEC4G Gene

Drugs & Compounds for CLEC4G Gene

(1) Additional Compounds for CLEC4G Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLEC4G: view

Transcripts for CLEC4G Gene

mRNA/cDNA for CLEC4G Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC4G

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4G Gene

No ASD Table

Relevant External Links for CLEC4G Gene

GeneLoc Exon Structure for
CLEC4G

Expression for CLEC4G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC4G Gene

This gene is overexpressed in Liver (x14.6), Brain - Cerebellum (x6.9), and Brain - Cerebellar Hemisphere (x5.4).

Protein differential expression in normal tissues from HIPED for CLEC4G Gene

This gene is overexpressed in Urine (39.1), Liver (14.0), Gallbladder (9.7), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC4G Gene



Protein tissue co-expression partners for CLEC4G Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLEC4G

SOURCE GeneReport for Unigene cluster for CLEC4G Gene:

Hs.220649

mRNA Expression by UniProt/SwissProt for CLEC4G Gene:

Q6UXB4-CLC4G_HUMAN
Tissue specificity: Expressed exclusively in fetal and adult liver and in lymph nodes. Specifically expressed by endothelial cells lining lymph node and liver sinuses (at protein level).

Evidence on tissue expression from TISSUES for CLEC4G Gene

  • Liver(4.5)
  • Lymph node(2.6)
genes like me logo Genes that share expression patterns with CLEC4G: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC4G Gene

Orthologs for CLEC4G Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC4G Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CLEC4G 30 31
  • 96.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CLEC4G 30 31
  • 79.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CLEC4G 30 31
  • 79.43 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Clec4g 30
  • 75.24 (n)
Mouse
(Mus musculus)
Mammalia Clec4g 30 17 31
  • 73.83 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CLEC4G 31
  • 44 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 43 (a)
OneToMany
-- 31
  • 38 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 30 (a)
OneToMany
Species where no ortholog for CLEC4G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CLEC4G Gene

ENSEMBL:
Gene Tree for CLEC4G (if available)
TreeFam:
Gene Tree for CLEC4G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLEC4G: view image

Paralogs for CLEC4G Gene

(2) SIMAP similar genes for CLEC4G Gene using alignment to 3 proteins:

  • CLC4G_HUMAN
  • B7ZKQ2_HUMAN
  • M0R277_HUMAN

Pseudogenes.org Pseudogenes for CLEC4G Gene

genes like me logo Genes that share paralogs with CLEC4G: view

Variants for CLEC4G Gene

Additional dbSNP identifiers (rs#s) for CLEC4G Gene

Structural Variations from Database of Genomic Variants (DGV) for CLEC4G Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv833731 CNV loss 17160897
nsv833732 CNV gain 17160897

Variation tolerance for CLEC4G Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC4G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC4G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLEC4G Gene

Disorders for CLEC4G Gene

MalaCards: The human disease database

(6) MalaCards diseases for CLEC4G Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphocytic choriomeningitis
  • lcm
japanese encephalitis
  • japanese b encephalitis
encephalitis
lassa fever
  • lf
argentine hemorrhagic fever
  • argentinian hemorrhagic fever
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CLEC4G

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CLEC4G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC4G Gene

Publications for CLEC4G Gene

  1. LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus. (PMID: 16051304) Gramberg T … Pöhlmann S (Virology 2005) 3 4 23
  2. Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node. (PMID: 14711836) Liu W … He F (The Journal of biological chemistry 2004) 3 4 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  4. Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin. (PMID: 24623090) Shimojima M … Maeda K (Archives of virology 2014) 3 4
  5. Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. (PMID: 22156524) Shimojima M … Kawaoka Y (Journal of virology 2012) 3 4

Products for CLEC4G Gene

Sources for CLEC4G Gene