Aliases for CLEC4D Gene
External Ids for CLEC4D Gene
Previous HGNC Symbols for CLEC4D Gene
Previous GeneCards Identifiers for CLEC4D Gene
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC4D Gene
CLEC4D (C-Type Lectin Domain Family 4 Member D) is a Protein Coding gene. Diseases associated with CLEC4D include Subcutaneous Mycosis and Chromoblastomycosis. Among its related pathways are Innate Immune System and CLEC7A (Dectin-1) signaling. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC6A.
UniProtKB/Swiss-Prot Summary for CLEC4D Gene
A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766). Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells (PubMed:14971047).