Aliases for CLEC4C Gene
External Ids for CLEC4C Gene
Previous HGNC Symbols for CLEC4C Gene
Previous GeneCards Identifiers for CLEC4C Gene
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC4C Gene
CLEC4C (C-Type Lectin Domain Family 4 Member C) is a Protein Coding gene. Diseases associated with CLEC4C include Cardiomyopathy, Dilated, 1C, With Or Without Left Ventricular Noncompaction and Pitt-Hopkins Syndrome. Among its related pathways are Innate Immune System and CLEC7A (Dectin-1) signaling. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC6A.
UniProtKB/Swiss-Prot Summary for CLEC4C Gene
Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283).