Aliases for CLEC2D Gene
External Ids for CLEC2D Gene
Previous GeneCards Identifiers for CLEC2D Gene
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for CLEC2D Gene
CLEC2D (C-Type Lectin Domain Family 2 Member D) is a Protein Coding gene. Diseases associated with CLEC2D include Inflammatory Bowel Disease 6. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC2A.
UniProtKB/Swiss-Prot Summary for CLEC2D Gene
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).