Aliases for CLEC1B Gene
External Ids for CLEC1B Gene
Previous GeneCards Identifiers for CLEC1B Gene
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
GeneCards Summary for CLEC1B Gene
CLEC1B (C-Type Lectin Domain Family 1 Member B) is a Protein Coding gene. Diseases associated with CLEC1B include Bleeding Disorder, Platelet-Type, 11 and Human Immunodeficiency Virus Type 1. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and G beta-gamma signalling through PI3Kgamma. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC12B.
UniProtKB/Swiss-Prot Summary for CLEC1B Gene
C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).
(Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485).
(Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).