Aliases for CLEC19A Gene

Aliases for CLEC19A Gene

  • C-Type Lectin Domain Containing 19A 2 3 5
  • C-Type Lectin Domain Family 19 Member A 2 3 4
  • C-Type Lectin Domain Family 19, Member A 2
  • CLEC19A 5

External Ids for CLEC19A Gene

Previous GeneCards Identifiers for CLEC19A Gene

  • GC00U926688

Summaries for CLEC19A Gene

GeneCards Summary for CLEC19A Gene

CLEC19A (C-Type Lectin Domain Containing 19A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG3A.

Additional gene information for CLEC19A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLEC19A Gene

Genomics for CLEC19A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CLEC19A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J019284 Enhancer 0.8 Ensembl ENCODE 600.7 -1.7 -1667 1.3 PRDM10 JUND ZIC2 ESR1 NFE2 ZNF316 MAFF MAFK FOSL1 MAFG CLEC19A piR-39300-056 lnc-GDE1-4 LOC105371114 SYT17
GH16J019304 Promoter 0.5 EPDnew 600.4 +19.1 19065 0.1 MAFG MAFK NONHSAG018780.2 CLEC19A lnc-GDE1-4 LOC105371114 TMC5
GH16J019285 Promoter 0.3 EPDnew 600.7 0.0 -19 0.1 CLEC19A piR-39300-056 lnc-GDE1-4 LOC105371114 SYT17
GH16J019286 Enhancer 0.3 Ensembl 600.7 -0.8 -830 0.2 ZNF664 CLEC19A piR-39300-056 lnc-GDE1-4 LOC105371114 SYT17
GH16J019289 Enhancer 0.6 ENCODE CraniofacialAtlas 0.7 +4.3 4302 1.1 USF1 ZFHX2 ADNP ZNF398 ZMYM3 EGR2 CLEC19A lnc-GDE1-4 LOC105371114 TMC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC19A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLEC19A

Genomic Locations for CLEC19A Gene

Genomic Locations for CLEC19A Gene
36,415 bases
Plus strand
36,407 bases
Plus strand

Genomic View for CLEC19A Gene

Genes around CLEC19A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC19A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC19A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC19A Gene

Proteins for CLEC19A Gene

  • Protein details for CLEC19A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 19 member A
    Protein Accession:
    Secondary Accessions:
    • Q0VF32

    Protein attributes for CLEC19A Gene

    136 amino acids
    Molecular mass:
    15448 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC19A Gene

Post-translational modifications for CLEC19A Gene

  • Glycosylation at Asn58

Other Protein References for CLEC19A Gene

No data available for DME Specific Peptides for CLEC19A Gene

Domains & Families for CLEC19A Gene

Gene Families for CLEC19A Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CLEC19A Gene

Suggested Antigen Peptide Sequences for CLEC19A Gene

GenScript: Design optimal peptide antigens:
  • C-type lectin domain family 19 member A (CL19A_HUMAN)
genes like me logo Genes that share domains with CLEC19A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CLEC19A Gene

Function for CLEC19A Gene

Phenotypes From GWAS Catalog for CLEC19A Gene

Gene Ontology (GO) - Molecular Function for CLEC19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC19A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC19A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC19A Gene

Localization for CLEC19A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC19A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC19A gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for CLEC19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CLEC19A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC19A Gene

Pathways & Interactions for CLEC19A Gene

PathCards logo

SuperPathways for CLEC19A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLEC19A Gene


No data available for Pathways by source and SIGNOR curated interactions for CLEC19A Gene

Drugs & Compounds for CLEC19A Gene

No Compound Related Data Available

Transcripts for CLEC19A Gene

mRNA/cDNA for CLEC19A Gene

3 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC19A

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC19A Gene

No ASD Table

Relevant External Links for CLEC19A Gene

GeneLoc Exon Structure for

Expression for CLEC19A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC19A Gene

Protein differential expression in normal tissues from HIPED for CLEC19A Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC19A Gene

Protein tissue co-expression partners for CLEC19A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLEC19A

SOURCE GeneReport for Unigene cluster for CLEC19A Gene:

genes like me logo Genes that share expression patterns with CLEC19A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC19A Gene

Orthologs for CLEC19A Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC19A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLEC19A 30
  • 98.75 (n)
(Canis familiaris)
Mammalia CLEC19A 30
  • 88.71 (n)
(Bos Taurus)
Mammalia CLEC19A 30 31
  • 88.35 (n)
(Ornithorhynchus anatinus)
Mammalia CLEC19A 31
  • 75 (a)
(Monodelphis domestica)
Mammalia CLEC19A 31
  • 70 (a)
(Gallus gallus)
Aves LOC771758 30
  • 76.97 (n)
CLEC19A 31
  • 58 (a)
(Anolis carolinensis)
Reptilia CLEC19A 31
  • 42 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia clec19a 30
  • 67.77 (n)
(Danio rerio)
Actinopterygii clec19a 30 31
  • 67.58 (n)
(Caenorhabditis elegans)
Secernentea clec-149 31
  • 9 (a)
Species where no ortholog for CLEC19A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CLEC19A Gene

Gene Tree for CLEC19A (if available)
Gene Tree for CLEC19A (if available)
Evolutionary constrained regions (ECRs) for CLEC19A: view image

Paralogs for CLEC19A Gene

Paralogs for CLEC19A Gene

(1) SIMAP similar genes for CLEC19A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLEC19A: view

Variants for CLEC19A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLEC19A Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
715677 Benign: not provided 19,298,815(+) C/T SYNONYMOUS_VARIANT
740596 Likely Benign: not provided 19,304,125(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CLEC19A Gene

Structural Variations from Database of Genomic Variants (DGV) for CLEC19A Gene

Variant ID Type Subtype PubMed ID
nsv1160368 CNV deletion 26073780
nsv436835 CNV insertion 17901297
nsv571582 CNV gain 21841781
nsv833162 CNV loss 17160897

Variation tolerance for CLEC19A Gene

Gene Damage Index Score: 7.55; 82.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC19A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC19A Gene

Disorders for CLEC19A Gene

No disorders were found for CLEC19A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC19A Gene

Publications for CLEC19A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for CLEC19A Gene

Sources for CLEC19A Gene