CLEC18C Gene (Protein Coding)

C-Type Lectin Domain Family 18 Member C

GC16P070173
GIFtS:
29
See more...

Aliases for CLEC18C Gene

Aliases for CLEC18C Gene

  • C-Type Lectin Domain Family 18 Member C 2 3 4 5
  • Mannose Receptor-Like Protein 3 3 4
  • Mannose Receptor-Like 3 2 3
  • C-Type Lectin Domain Family 18, Member C 2
  • MGC34761 2
  • CLEC18C 5
  • MRCL3 3
  • MRLP3 4
  • MRCL 3

External Ids for CLEC18C Gene

Previous HGNC Symbols for CLEC18C Gene

  • MRCL3

Previous GeneCards Identifiers for CLEC18C Gene

  • GC16P068767
  • GC16P070207
  • GC16M060201

Summaries for CLEC18C Gene

GeneCards Summary for CLEC18C Gene

CLEC18C (C-Type Lectin Domain Family 18 Member C) is a Protein Coding gene. Diseases associated with CLEC18C include Cellular Myxoid Liposarcoma and Pleomorphic Liposarcoma. Among its related pathways are Guidance Cues and Growth Cone Motility and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC18A.

UniProtKB/Swiss-Prot Summary for CLEC18C Gene

  • Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.

Additional gene information for CLEC18C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLEC18C Gene

Genomics for CLEC18C Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CLEC18C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC18C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLEC18C

Top Transcription factor binding sites by QIAGEN in the CLEC18C gene promoter:
  • AML1a
  • AREB6
  • ATF6
  • C/EBPalpha
  • ER-alpha
  • Olf-1
  • Pax-5
  • STAT5A
  • Tal-1

Genomic Locations for CLEC18C Gene

Genomic Locations for CLEC18C Gene
chr16:70,173,322-70,187,361
(GRCh38/hg38)
Size:
14,040 bases
Orientation:
Plus strand
chr16:70,207,225-70,221,264
(GRCh37/hg19)
Size:
14,040 bases
Orientation:
Plus strand

Genomic View for CLEC18C Gene

Genes around CLEC18C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC18C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC18C Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CLEC18C Gene

Proteins for CLEC18C Gene

Products:

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  • Protein details for CLEC18C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCF0-CL18C_HUMAN
    Recommended name:
    C-type lectin domain family 18 member C
    Protein Accession:
    Q8NCF0
    Secondary Accessions:
    • Q8IUW8

    Protein attributes for CLEC18C Gene

    Size:
    446 amino acids
    Molecular mass:
    49585 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39068.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC18C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC18C Gene

Post-translational modifications for CLEC18C Gene

  • Glycosylation at Asn144
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC18C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC18C Gene

Domains & Families for CLEC18C Gene

Gene Families for CLEC18C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CLEC18C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLEC18C Gene

GenScript: Design optimal peptide antigens:
  • Mannose receptor-like protein 3 (CL18C_HUMAN)
genes like me logo Genes that share domains with CLEC18C: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CLEC18C Gene

Function for CLEC18C Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CLEC18C Gene

UniProtKB/Swiss-Prot Function:
Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.

Phenotypes From GWAS Catalog for CLEC18C Gene

Gene Ontology (GO) - Molecular Function for CLEC18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:0030247 polysaccharide binding IDA 26170455
genes like me logo Genes that share ontologies with CLEC18C: view

Phenotypes for CLEC18C Gene

GenomeRNAi human phenotypes for CLEC18C:
genes like me logo Genes that share phenotypes with CLEC18C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC18C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC18C Gene

Localization for CLEC18C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC18C Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC18C gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
extracellular 4
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for CLEC18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005768 endosome TAS 26170455
GO:0005783 endoplasmic reticulum TAS 26170455
GO:0005794 Golgi apparatus TAS 26170455
genes like me logo Genes that share ontologies with CLEC18C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC18C Gene

Pathways & Interactions for CLEC18C Gene

PathCards logo

SuperPathways for CLEC18C Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
Activation of PKA through GPCR
.71
PKA Signaling
.56
2 PAK Pathway
Antioxidant Action of Vitamin-C
.56
PAK Pathway
.56
Epithelial Adherens Junctions
.36
3 Actin Nucleation by ARP-WASP Complex
Actin Nucleation by ARP-WASP Complex
.66
RhoA Pathway
.35
4 RhoGDI Pathway
Fc-GammaR-Mediated Phagocytosis in Macrophages
.33
RhoGDI Pathway
.33
5 Sweet Taste Signaling
Cellular Effects of Sildenafil
.46
genes like me logo Genes that share pathways with CLEC18C: view

Pathways by source for CLEC18C Gene

16 Qiagen pathways for CLEC18C Gene
  • Actin Nucleation by ARP-WASP Complex
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Antioxidant Action of Vitamin-C
  • cAMP Pathway

Interacting Proteins for CLEC18C Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000477846 Q8NCF0-CL18C_HUMAN for CLEC18C Gene via STRING IID

GPS-Prot Interaction Network for CLEC18C

Gene Ontology (GO) - Biological Process for CLEC18C Gene

None

No data available for SIGNOR curated interactions for CLEC18C Gene

Drugs & Compounds for CLEC18C Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CLEC18C Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CLEC18C Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC18C

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC18C Gene

No ASD Table

Relevant External Links for CLEC18C Gene

GeneLoc Exon Structure for
CLEC18C

Expression for CLEC18C Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC18C Gene

mRNA expression in normal human tissues for CLEC18C Gene
mRNA expression by BioGPS for CLEC18C GenemRNA expression by GTEx for CLEC18C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC18C Gene

This gene is overexpressed in Kidney - Cortex (x30.0) and Testis (x6.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLEC18C

mRNA Expression by UniProt/SwissProt for CLEC18C Gene:

Q8NCF0-CL18C_HUMAN
Tissue specificity: Detected in peripheral blood cells.

Evidence on tissue expression from TISSUES for CLEC18C Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with CLEC18C: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC18C Gene

Orthologs for CLEC18C Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC18C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia -- 31
  • 95 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 72 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 70 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia -- 31
  • 68 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Clec18a 31
  • 62 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia MRCL 31
  • 46 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves -- 31
  • 64 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea lon-1 31
  • 23 (a)
 OneToMany
Species where no ortholog for CLEC18C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for CLEC18C Gene

ENSEMBL:
Gene Tree for CLEC18C (if available)
TreeFam:
Gene Tree for CLEC18C (if available)

Paralogs for CLEC18C Gene

Paralogs for CLEC18C Gene

(3) SIMAP similar genes for CLEC18C Gene using alignment to 4 proteins:

  • CL18C_HUMAN
  • F5H550_HUMAN
  • H3BSF2_HUMAN
  • H3BUD1_HUMAN
genes like me logo Genes that share paralogs with CLEC18C: view

Variants for CLEC18C Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for CLEC18C Gene

Structural Variations from Database of Genomic Variants (DGV) for CLEC18C Gene

Variant ID Type Subtype PubMed ID
dgv1365n106 CNV duplication 24896259
dgv25e213 CNV gain 24956385
dgv2998n100 CNV gain 25217958
dgv3005n100 CNV gain+loss 25217958
dgv3006n100 CNV loss 25217958
dgv3011n100 CNV gain+loss 25217958
dgv3012n100 CNV loss 25217958
dgv3013n100 CNV gain 25217958
dgv485n67 CNV loss 20364138
dgv849e212 CNV gain 25503493
dgv851e212 CNV loss 25503493
esv1007882 CNV loss 20482838
esv25519 CNV gain+loss 19812545
esv2657437 CNV deletion 23128226
esv2758652 CNV gain+loss 17122850
esv2760404 CNV gain+loss 21179565
esv2762188 CNV gain+loss 21179565
esv3344778 CNV duplication 20981092
esv33745 CNV gain+loss 17666407
nsv1058068 CNV gain+loss 25217958
nsv1060953 CNV gain 25217958
nsv1062268 CNV gain+loss 25217958
nsv1146597 CNV duplication 26484159
nsv1148716 CNV duplication 26484159
nsv1853 CNV deletion 18451855
nsv428328 CNV gain+loss 18775914
nsv436059 CNV insertion 17901297
nsv469646 CNV gain 16826518
nsv471695 CNV loss 15918152
nsv482196 CNV gain 20164927
nsv572916 CNV loss 21841781
nsv7285 OTHER inversion 18451855
nsv820087 CNV loss 19587683
nsv827728 CNV loss 20364138
nsv833269 CNV loss 17160897
nsv833271 CNV gain+loss 17160897
nsv9455 CNV gain+loss 18304495
nsv977993 CNV duplication 23825009

Variation tolerance for CLEC18C Gene

Gene Damage Index Score: 2.82; 47.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC18C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC18C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLEC18C Gene

Disorders for CLEC18C Gene

MalaCards: The human disease database

(6) MalaCards diseases for CLEC18C Gene - From: DISEASES

Disorder Aliases PubMed IDs
cellular myxoid liposarcoma
  • round cell liposarcoma
pleomorphic liposarcoma
  • pls
myxoid liposarcoma
  • liposarcoma
well-differentiated liposarcoma
  • pleomorphic lipoma
synovium cancer
  • malignant tumor of synovium
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CLEC18C

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CLEC18C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC18C Gene

Publications for CLEC18C Gene

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. (PMID: 26170455) Huang YL … Hsieh SL (The Journal of biological chemistry 2015) 2 3 4
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The C-type lectin-like domain superfamily. (PMID: 16336259) Zelensky AN … Gready JE (The FEBS journal 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4

ExternalLinks

View latest publications for CLEC18C gene in Mastermind

Products for CLEC18C Gene

  • Biorbyt antibodies for CLEC18C

Sources for CLEC18C Gene