Aliases for CLEC18B Gene

Aliases for CLEC18B Gene

  • C-Type Lectin Domain Family 18 Member B 2 3 4 5
  • Mannose Receptor-Like Protein 1 3 4
  • Mannose Receptor-Like 2 2 3
  • C-Type Lectin Domain Family 18, Member B 2
  • Secretory Protein LOC497190 3
  • CLEC18B 5
  • MRCL2 3
  • MRLP1 4

External Ids for CLEC18B Gene

Previous HGNC Symbols for CLEC18B Gene

  • MRCL2

Previous GeneCards Identifiers for CLEC18B Gene

  • GC16M073002

Summaries for CLEC18B Gene

GeneCards Summary for CLEC18B Gene

CLEC18B (C-Type Lectin Domain Family 18 Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC18C.

UniProtKB/Swiss-Prot Summary for CLEC18B Gene

  • Binds polysaccharides in a Ca(2+)-independent manner (By similarity).

Additional gene information for CLEC18B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLEC18B Gene

Genomics for CLEC18B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CLEC18B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC18B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLEC18B

Top Transcription factor binding sites by QIAGEN in the CLEC18B gene promoter:
  • AML1a
  • AREB6
  • ATF6
  • C/EBPalpha
  • GR
  • GR-alpha
  • GR-beta
  • Olf-1
  • STAT5A
  • USF-1

Genomic Locations for CLEC18B Gene

Genomic Locations for CLEC18B Gene
chr16:74,408,270-74,422,248
(GRCh38/hg38)
Size:
13,979 bases
Orientation:
Minus strand
chr16:74,442,529-74,455,368
(GRCh37/hg19)
Size:
12,840 bases
Orientation:
Minus strand

Genomic View for CLEC18B Gene

Genes around CLEC18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC18B Gene

Proteins for CLEC18B Gene

  • Protein details for CLEC18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXF7-CL18B_HUMAN
    Recommended name:
    C-type lectin domain family 18 member B
    Protein Accession:
    Q6UXF7
    Secondary Accessions:
    • B4DF90

    Protein attributes for CLEC18B Gene

    Size:
    455 amino acids
    Molecular mass:
    50490 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLEC18B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC18B Gene

Post-translational modifications for CLEC18B Gene

  • Glycosylation at Asn144

Other Protein References for CLEC18B Gene

No data available for DME Specific Peptides for CLEC18B Gene

Domains & Families for CLEC18B Gene

Gene Families for CLEC18B Gene

Suggested Antigen Peptide Sequences for CLEC18B Gene

GenScript: Design optimal peptide antigens:
  • Mannose receptor-like protein 1 (CL18B_HUMAN)
genes like me logo Genes that share domains with CLEC18B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CLEC18B Gene

Function for CLEC18B Gene

Molecular function for CLEC18B Gene

UniProtKB/Swiss-Prot Function:
Binds polysaccharides in a Ca(2+)-independent manner (By similarity).

Phenotypes From GWAS Catalog for CLEC18B Gene

Gene Ontology (GO) - Molecular Function for CLEC18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:0030247 polysaccharide binding IBA 21873635
genes like me logo Genes that share ontologies with CLEC18B: view

Phenotypes for CLEC18B Gene

genes like me logo Genes that share phenotypes with CLEC18B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC18B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC18B Gene

Localization for CLEC18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC18B Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC18B gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
extracellular 4
plasma membrane 1
cytoskeleton 1
nucleus 1
peroxisome 0
cytosol 0

Gene Ontology (GO) - Cellular Components for CLEC18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005768 endosome TAS 26170455
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus TAS 26170455
genes like me logo Genes that share ontologies with CLEC18B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC18B Gene

Pathways & Interactions for CLEC18B Gene

PathCards logo

SuperPathways for CLEC18B Gene

No Data Available

Interacting Proteins for CLEC18B Gene

Gene Ontology (GO) - Biological Process for CLEC18B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLEC18B Gene

Drugs & Compounds for CLEC18B Gene

No Compound Related Data Available

Transcripts for CLEC18B Gene

mRNA/cDNA for CLEC18B Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC18B

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC18B Gene

No ASD Table

Relevant External Links for CLEC18B Gene

GeneLoc Exon Structure for
CLEC18B

Expression for CLEC18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC18B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC18B Gene

This gene is overexpressed in Kidney - Cortex (x21.8) and Testis (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLEC18B

SOURCE GeneReport for Unigene cluster for CLEC18B Gene:

Hs.454670

Evidence on tissue expression from TISSUES for CLEC18B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CLEC18B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC18B Gene

Orthologs for CLEC18B Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC18B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 98 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia CLEC18A 30
  • 85.71 (n)
-- 31
  • 68 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia MRCL 30 31
  • 83.06 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Clec18a 30 17 31
  • 82.58 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Clec18a 30
  • 81.92 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 72 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 70 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CLEC18A 30
  • 72.4 (n)
-- 31
  • 65 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea lon-1 31
  • 23 (a)
OneToMany
Species where no ortholog for CLEC18B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for CLEC18B Gene

ENSEMBL:
Gene Tree for CLEC18B (if available)
TreeFam:
Gene Tree for CLEC18B (if available)

Paralogs for CLEC18B Gene

(2) SIMAP similar genes for CLEC18B Gene using alignment to 1 proteins:

  • CL18B_HUMAN
genes like me logo Genes that share paralogs with CLEC18B: view

Variants for CLEC18B Gene

Additional dbSNP identifiers (rs#s) for CLEC18B Gene

Structural Variations from Database of Genomic Variants (DGV) for CLEC18B Gene

Variant ID Type Subtype PubMed ID
dgv488n67 CNV loss 20364138
dgv852e212 CNV loss 25503493
dgv853e212 CNV gain 25503493
dgv854e212 CNV loss 25503493
dgv855e212 CNV gain 25503493
esv22159 CNV gain+loss 19812545
esv2758656 CNV gain+loss 17122850
esv2760420 CNV gain+loss 21179565
esv2762054 CNV gain 21179565
esv32572 CNV gain 17666407
esv3571520 CNV gain 25503493
nsv1065964 CNV gain 25217958
nsv1076436 CNV duplication 25765185
nsv1118585 CNV duplication 24896259
nsv1124743 CNV duplication 24896259
nsv1151078 CNV duplication 26484159
nsv1160432 CNV duplication 26073780
nsv442726 CNV gain 18776908
nsv509632 CNV insertion 20534489
nsv572974 CNV loss 21841781
nsv819754 CNV loss 19587683
nsv821530 CNV duplication 20802225
nsv827736 CNV gain 20364138
nsv833277 CNV loss 17160897
nsv833278 CNV loss 17160897
nsv9457 CNV gain+loss 18304495
nsv974836 CNV duplication 23825009

Variation tolerance for CLEC18B Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC18B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLEC18B Gene

Disorders for CLEC18B Gene

No disorders were found for CLEC18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC18B Gene

Publications for CLEC18B Gene

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. (PMID: 26170455) Huang YL … Hsieh SL (The Journal of biological chemistry 2015) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  3. Overexpression of CLEC18B Associates With the Proliferation, Migration, and Prognosis of Glioblastoma. (PMID: 29914265) Guo RM … Yang B (ASN neuro 2018) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for CLEC18B Gene

Sources for CLEC18B Gene