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Aliases for CLEC18B Gene

Aliases for CLEC18B Gene

  • C-Type Lectin Domain Family 18 Member B 2 3 5
  • Mannose Receptor-Like Protein 1 3 4
  • Mannose Receptor-Like 2 2 3
  • C-Type Lectin Domain Family 18, Member B 2
  • Secretory Protein LOC497190 3
  • MRCL2 3
  • MRLP1 4

External Ids for CLEC18B Gene

Previous HGNC Symbols for CLEC18B Gene

  • MRCL2

Previous GeneCards Identifiers for CLEC18B Gene

  • GC16M073002

Summaries for CLEC18B Gene

GeneCards Summary for CLEC18B Gene

CLEC18B (C-Type Lectin Domain Family 18 Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC18A.

UniProtKB/Swiss-Prot for CLEC18B Gene

  • Binds polysaccharides in a Ca(2+)-independent manner (By similarity).

Additional gene information for CLEC18B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC18B Gene

Genomics for CLEC18B Gene

GeneHancer (GH) Regulatory Elements for CLEC18B Gene

Promoters and enhancers for CLEC18B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I074421 Promoter 0.5 EPDnew 550.8 +0.8 752 0.1 CLEC18B ENSG00000261170 LOC105376772
GH16I074479 Enhancer 1 Ensembl ENCODE 19.8 -58.2 -58233 2.8 SIN3A FEZF1 RAD21 RFX5 TCF12 EGR2 GATAD2B ZNF843 SP1 ZNF217 RFWD3 CLEC18B RNU6-237P ENSG00000207525 GC16M074463 RPS10P23 GLG1
GH16I074605 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.2 -185.1 -185110 4.3 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GLG1 RFWD3 ENSG00000259972 RPL21P118 ENSG00000260884 ENSG00000214331 BCAR1 TMEM231 WDR59 CLEC18B
GH16I074366 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 5.9 +54.1 54050 2.4 CLOCK MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLR2B E2F8 KLF13 ENSG00000261079 ENSG00000214331 LOC283922 PSMD7 CLEC18B RFWD3
GH16I074476 Enhancer 0.6 ENCODE 12.1 -55.4 -55374 1.8 FOXA2 SAP130 ZBTB11 ZFP64 ZC3H11A ZNF623 ZNF781 ZNF518A ZNF697 ZNF555 RFWD3 ENSG00000214331 CLEC18B ENSG00000260884 GLG1 RPL21P118 WDR59 ZFP1 ENSG00000259972 ENSG00000261079
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLEC18B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLEC18B gene promoter:

Genomic Locations for CLEC18B Gene

Genomic Locations for CLEC18B Gene
13,979 bases
Minus strand

Genomic View for CLEC18B Gene

Genes around CLEC18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC18B Gene

Proteins for CLEC18B Gene

  • Protein details for CLEC18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 18 member B
    Protein Accession:
    Secondary Accessions:
    • B4DF90

    Protein attributes for CLEC18B Gene

    455 amino acids
    Molecular mass:
    50490 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLEC18B Gene


neXtProt entry for CLEC18B Gene

Post-translational modifications for CLEC18B Gene

Other Protein References for CLEC18B Gene

No data available for DME Specific Peptides for CLEC18B Gene

Domains & Families for CLEC18B Gene

Suggested Antigen Peptide Sequences for CLEC18B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLEC18B: view

No data available for UniProtKB/Swiss-Prot for CLEC18B Gene

Function for CLEC18B Gene

Molecular function for CLEC18B Gene

UniProtKB/Swiss-Prot Function:
Binds polysaccharides in a Ca(2+)-independent manner (By similarity).

Gene Ontology (GO) - Molecular Function for CLEC18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC18B: view

Phenotypes for CLEC18B Gene

GenomeRNAi human phenotypes for CLEC18B:
genes like me logo Genes that share phenotypes with CLEC18B: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC18B Gene

Localization for CLEC18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC18B Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC18B gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 5
plasma membrane 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CLEC18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005768 endosome TAS 26170455
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus TAS 26170455
GO:0016529 sarcoplasmic reticulum TAS 26170455
genes like me logo Genes that share ontologies with CLEC18B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC18B Gene

Pathways & Interactions for CLEC18B Gene

SuperPathways for CLEC18B Gene

No Data Available

Interacting Proteins for CLEC18B Gene

Gene Ontology (GO) - Biological Process for CLEC18B Gene


No data available for Pathways by source and SIGNOR curated interactions for CLEC18B Gene

Drugs & Compounds for CLEC18B Gene

No Compound Related Data Available

Transcripts for CLEC18B Gene

mRNA/cDNA for CLEC18B Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC18B Gene

C-type lectin domain family 18, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC18B Gene

No ASD Table

Relevant External Links for CLEC18B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC18B Gene

mRNA differential expression in normal tissues according to GTEx for CLEC18B Gene

This gene is overexpressed in Kidney - Cortex (x21.8) and Testis (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of CLEC18B Gene:


SOURCE GeneReport for Unigene cluster for CLEC18B Gene:


Evidence on tissue expression from TISSUES for CLEC18B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CLEC18B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC18B Gene

Orthologs for CLEC18B Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC18B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 98 (a)
(Canis familiaris)
Mammalia CLEC18A 33
  • 85.71 (n)
-- 34
  • 68 (a)
(Bos Taurus)
Mammalia MRCL 33 34
  • 83.06 (n)
(Mus musculus)
Mammalia Clec18a 33 16 34
  • 82.58 (n)
(Rattus norvegicus)
Mammalia Clec18a 33
  • 81.92 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
(Gallus gallus)
Aves CLEC18A 33
  • 72.4 (n)
-- 34
  • 65 (a)
(Caenorhabditis elegans)
Secernentea lon-1 34
  • 23 (a)
Species where no ortholog for CLEC18B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CLEC18B Gene

Gene Tree for CLEC18B (if available)
Gene Tree for CLEC18B (if available)

Paralogs for CLEC18B Gene

Paralogs for CLEC18B Gene

(2) SIMAP similar genes for CLEC18B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLEC18B: view

Variants for CLEC18B Gene

Sequence variations from dbSNP and Humsavar for CLEC18B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000262178 -- 74,422,771(-) C/T upstream_transcript_variant
rs1000314176 -- 74,423,861(-) T/C upstream_transcript_variant
rs1000599627 -- 74,418,693(-) T/C/G intron_variant
rs1000650571 -- 74,419,332(-) G/A intron_variant
rs1002323828 -- 74,421,565(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC18B Gene

Variant ID Type Subtype PubMed ID
nsv974836 CNV duplication 23825009
nsv9457 CNV gain+loss 18304495
nsv833278 CNV loss 17160897
nsv833277 CNV loss 17160897
nsv827736 CNV gain 20364138
nsv821530 CNV duplication 20802225
nsv819754 CNV loss 19587683
nsv572974 CNV loss 21841781
nsv509632 CNV insertion 20534489
nsv442726 CNV gain 18776908
nsv1160432 CNV duplication 26073780
nsv1151078 CNV duplication 26484159
nsv1124743 CNV duplication 24896259
nsv1118585 CNV duplication 24896259
nsv1076436 CNV duplication 25765185
nsv1065964 CNV gain 25217958
esv3571520 CNV gain 25503493
esv32572 CNV gain 17666407
esv2762054 CNV gain 21179565
esv2760420 CNV gain+loss 21179565
esv2758656 CNV gain+loss 17122850
esv22159 CNV gain+loss 19812545
dgv855e212 CNV gain 25503493
dgv854e212 CNV loss 25503493
dgv853e212 CNV gain 25503493
dgv852e212 CNV loss 25503493
dgv488n67 CNV loss 20364138

Variation tolerance for CLEC18B Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC18B Gene

Disorders for CLEC18B Gene

Additional Disease Information for CLEC18B

No disorders were found for CLEC18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC18B Gene

Publications for CLEC18B Gene

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. (PMID: 26170455) Huang YL … Hsieh SL (The Journal of biological chemistry 2015) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The C-type lectin-like domain superfamily. (PMID: 16336259) Zelensky AN … Gready JE (The FEBS journal 2005) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for CLEC18B Gene

Sources for CLEC18B Gene

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