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Aliases for CLEC18A Gene

Aliases for CLEC18A Gene

  • C-Type Lectin Domain Family 18 Member A 2 3 5
  • Mannose Receptor-Like Protein 2 3 4
  • MRLP2 3 4
  • C-Type Lectin Domain Family 18, Member A 2
  • Mannose Receptor-Like Protein 3 3
  • Mannose Receptor-Like 1 3
  • Mannose Receptor-Like 2
  • MRCL1 3
  • MRCL 3

External Ids for CLEC18A Gene

Previous HGNC Symbols for CLEC18A Gene

  • MRCL

Previous GeneCards Identifiers for CLEC18A Gene

  • GC16P068544
  • GC16P069985

Summaries for CLEC18A Gene

Entrez Gene Summary for CLEC18A Gene

  • This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]

GeneCards Summary for CLEC18A Gene

CLEC18A (C-Type Lectin Domain Family 18 Member A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC18C.

UniProtKB/Swiss-Prot for CLEC18A Gene

  • Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455).

Additional gene information for CLEC18A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC18A Gene

Genomics for CLEC18A Gene

GeneHancer (GH) Regulatory Elements for CLEC18A Gene

Promoters and enhancers for CLEC18A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I069950 Promoter 0.5 EPDnew 550.8 +0.5 462 0.1 CLEC18A GC16P069952
GH16I070064 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 54.1 +115.2 115158 2.5 CLOCK ATF1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B ZNF48 GLIS2 ZNF207 PDXDC2P-NPIPB14P PDXDC2P CLEC18A NONOP1 NPIPB14P NFAT5 SF3B3 NOB1 PDPR DDX19B
GH16I070113 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 36.1 +163.9 163941 2.1 HDGF CLOCK ATF1 MLX ARID4B SIN3A FEZF1 DMAP1 BRCA1 GLIS2 PDPR CLEC18A AARS COG4 EXOSC6 PIR41675
GH16I070436 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.7 +487.7 487747 3.9 FEZF1 YY1 SLC30A9 ZNF213 ZNF143 SP3 MEF2D SSRP1 ZNF610 GLIS1 ST3GAL2 SMG1P7 CLEC18A HYDIN COG4 LOC400541 AARS DDX19B FUK PDXDC2P-NPIPB14P
GH16I070025 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 49.1 +75.8 75844 1.7 JUN CLEC18A NPIPB14P PDXDC2P-NPIPB14P WWP2 EXOSC6 MIR1972-2 PDXDC2P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLEC18A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLEC18A gene promoter:

Genomic Locations for CLEC18A Gene

Genomic Locations for CLEC18A Gene
14,059 bases
Plus strand

Genomic View for CLEC18A Gene

Genes around CLEC18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC18A Gene

Proteins for CLEC18A Gene

  • Protein details for CLEC18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 18 member A
    Protein Accession:
    Secondary Accessions:
    • A8K1G9
    • Q6DCB3
    • Q7Z5K9
    • Q96HH2

    Protein attributes for CLEC18A Gene

    446 amino acids
    Molecular mass:
    49602 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH08616.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC18A Gene


neXtProt entry for CLEC18A Gene

Post-translational modifications for CLEC18A Gene

No data available for DME Specific Peptides for CLEC18A Gene

Domains & Families for CLEC18A Gene

Gene Families for CLEC18A Gene

Suggested Antigen Peptide Sequences for CLEC18A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLEC18A: view

No data available for UniProtKB/Swiss-Prot for CLEC18A Gene

Function for CLEC18A Gene

Molecular function for CLEC18A Gene

UniProtKB/Swiss-Prot Function:
Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455).

Phenotypes From GWAS Catalog for CLEC18A Gene

Gene Ontology (GO) - Molecular Function for CLEC18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
GO:0030247 polysaccharide binding IDA 26170455
genes like me logo Genes that share ontologies with CLEC18A: view

Phenotypes for CLEC18A Gene

GenomeRNAi human phenotypes for CLEC18A:
genes like me logo Genes that share phenotypes with CLEC18A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC18A Gene

Localization for CLEC18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC18A Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC18A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 5
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLEC18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 26170455
GO:0005768 endosome TAS 26170455
GO:0005783 endoplasmic reticulum TAS 26170455
GO:0005794 Golgi apparatus TAS 26170455
genes like me logo Genes that share ontologies with CLEC18A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC18A Gene

Pathways & Interactions for CLEC18A Gene

SuperPathways for CLEC18A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLEC18A Gene


No data available for Pathways by source and SIGNOR curated interactions for CLEC18A Gene

Drugs & Compounds for CLEC18A Gene

No Compound Related Data Available

Transcripts for CLEC18A Gene

Unigene Clusters for CLEC18A Gene

C-type lectin domain family 18, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC18A Gene

No ASD Table

Relevant External Links for CLEC18A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC18A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC18A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC18A Gene

This gene is overexpressed in Kidney - Cortex (x17.7) and Artery - Aorta (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of CLEC18A Gene:


SOURCE GeneReport for Unigene cluster for CLEC18A Gene:


mRNA Expression by UniProt/SwissProt for CLEC18A Gene:

Tissue specificity: Dectected in all cell lines tested and in peripheral blood cells.

Evidence on tissue expression from TISSUES for CLEC18A Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with CLEC18A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC18A Gene

Orthologs for CLEC18A Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC18A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLEC18A 34
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
(Canis familiaris)
Mammalia -- 34
  • 68 (a)
(Mus musculus)
Mammalia Clec18a 34
  • 63 (a)
(Bos Taurus)
Mammalia MRCL 34
  • 46 (a)
(Gallus gallus)
Aves -- 34
  • 65 (a)
(Caenorhabditis elegans)
Secernentea lon-1 34
  • 23 (a)
Species where no ortholog for CLEC18A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CLEC18A Gene

Gene Tree for CLEC18A (if available)
Gene Tree for CLEC18A (if available)

Paralogs for CLEC18A Gene

Paralogs for CLEC18A Gene

(3) SIMAP similar genes for CLEC18A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLEC18A: view

Variants for CLEC18A Gene

Sequence variations from dbSNP and Humsavar for CLEC18A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000491644 -- 69,967,317(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000570275 -- 69,952,801(+) C/T intron_variant
rs1001195522 -- 69,965,350(+) T/C genic_downstream_transcript_variant, intron_variant
rs1001995751 -- 69,966,531(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1002009958 -- 69,950,434(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC18A Gene

Variant ID Type Subtype PubMed ID
dgv2997n100 CNV loss 25217958
nsv974827 CNV duplication 23825009
nsv9452 CNV loss 18304495
nsv509630 CNV insertion 20534489
nsv428328 CNV gain+loss 18775914
nsv1853 CNV deletion 18451855
nsv1151295 CNV duplication 26484159
nsv1124741 CNV duplication 24896259
nsv1110289 CNV duplication 24896259
nsv1071293 CNV deletion 25765185
nsv1056602 CNV gain 25217958
esv3428880 CNV duplication 20981092
esv2762188 CNV gain+loss 21179565
esv2758652 CNV gain+loss 17122850
esv2714669 CNV deletion 23290073
esv25670 CNV gain+loss 19812545
dgv849e212 CNV gain 25503493
dgv848e212 CNV loss 25503493
dgv485n67 CNV loss 20364138
dgv3000n100 CNV gain+loss 25217958
dgv2999n100 CNV loss 25217958
dgv2998n100 CNV gain 25217958

Variation tolerance for CLEC18A Gene

Gene Damage Index Score: 11.26; 92.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC18A Gene

Disorders for CLEC18A Gene

Additional Disease Information for CLEC18A

No disorders were found for CLEC18A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC18A Gene

Publications for CLEC18A Gene

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. (PMID: 26170455) Huang YL … Hsieh SL (The Journal of biological chemistry 2015) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CLEC18A Gene

Sources for CLEC18A Gene

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