This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by... See more...

Aliases for CLEC18A Gene

Aliases for CLEC18A Gene

  • C-Type Lectin Domain Family 18 Member A 2 3 4 5
  • Mannose Receptor-Like Protein 2 3 4
  • MRLP2 3 4
  • C-Type Lectin Domain Family 18, Member A 2
  • Mannose Receptor-Like Protein 3 3
  • Mannose Receptor-Like 1 3
  • Mannose Receptor-Like 2
  • MRCL1 3
  • MRCL 3

External Ids for CLEC18A Gene

Previous HGNC Symbols for CLEC18A Gene

  • MRCL

Previous GeneCards Identifiers for CLEC18A Gene

  • GC16P068544
  • GC16P069985

Summaries for CLEC18A Gene

Entrez Gene Summary for CLEC18A Gene

  • This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]

GeneCards Summary for CLEC18A Gene

CLEC18A (C-Type Lectin Domain Family 18 Member A) is a Protein Coding gene. Diseases associated with CLEC18A include Cellular Myxoid Liposarcoma. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot Summary for CLEC18A Gene

  • Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455).

Additional gene information for CLEC18A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLEC18A Gene

Genomics for CLEC18A Gene

GeneHancer (GH) Regulatory Elements for CLEC18A Gene

Promoters and enhancers for CLEC18A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J069950 Promoter/Enhancer 0.5 EPDnew Ensembl 772.5 +1.8 1807 3.2 CLEC18A NPIPB14P COG4 piR-50090-001
GH16J070063 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 54.1 +115.1 115107 3.8 SREBF1 RBPJ MNT NKRF ELF3 POLR2A ZFX SP1 ZNF384 MLLT1 PDXDC2P-NPIPB14P PDXDC2P lnc-EXOSC6-3 lnc-EXOSC6-8 CLEC18A ENSG00000260290 NPIPB14P NFAT5 PDPR SF3B3
GH16J070113 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 36.1 +163.9 163907 3.8 ZBTB40 MLX USF2 L3MBTL2 MAX MNT NKRF GTF2F1 POLR2A CBFA2T2 PDPR RF00017-2131 CLEC18A COG4 FCSK ENSG00000247228 AARS1 NPIPB14P SF3B3 VAC14
GH16J070250 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 42.2 +300.5 300540 3.9 SIN3A ZBTB40 CTCF ZBTB6 MLX RBPJ POLR2A HCFC1 MIXL1 MYC EXOSC6 HSALNG0112427 DDX19B SF3B3 COG4 CLEC18A NFAT5 PDPR ENSG00000247228 ENSG00000260290
GH16J070023 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 49.1 +75.3 75307 5 MAFK ZNF316 MAFG JUN EMSY CLEC18A NPIPB14P PDXDC2P-NPIPB14P PDXDC2P ENSG00000261777 WWP2 EXOSC6 MIR1972-2 HE856235-002 lnc-EXOSC6-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC18A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLEC18A gene promoter:
  • c-Myc
  • ER-alpha
  • GR
  • GR-alpha
  • GR-beta
  • Max1
  • Pbx1a
  • STAT5A
  • Zic1
  • ZIC2

Genomic Locations for CLEC18A Gene

Genomic Locations for CLEC18A Gene
chr16:69,950,394-69,964,452
(GRCh38/hg38)
Size:
14,059 bases
Orientation:
Plus strand
chr16:69,984,626-69,998,141
(GRCh37/hg19)
Size:
13,516 bases
Orientation:
Plus strand

Genomic View for CLEC18A Gene

Genes around CLEC18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC18A Gene

Proteins for CLEC18A Gene

  • Protein details for CLEC18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5D8T8-CL18A_HUMAN
    Recommended name:
    C-type lectin domain family 18 member A
    Protein Accession:
    A5D8T8
    Secondary Accessions:
    • A8K1G9
    • Q6DCB3
    • Q7Z5K9
    • Q96HH2

    Protein attributes for CLEC18A Gene

    Size:
    446 amino acids
    Molecular mass:
    49602 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08616.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC18A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC18A Gene

Post-translational modifications for CLEC18A Gene

No data available for DME Specific Peptides for CLEC18A Gene

Domains & Families for CLEC18A Gene

Gene Families for CLEC18A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CLEC18A Gene

GenScript: Design optimal peptide antigens:
  • Mannose receptor-like protein 2 (CL18A_HUMAN)
genes like me logo Genes that share domains with CLEC18A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CLEC18A Gene

Function for CLEC18A Gene

Molecular function for CLEC18A Gene

UniProtKB/Swiss-Prot Function:
Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455).

Phenotypes From GWAS Catalog for CLEC18A Gene

Gene Ontology (GO) - Molecular Function for CLEC18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
GO:0030247 polysaccharide binding IDA 26170455
genes like me logo Genes that share ontologies with CLEC18A: view

Phenotypes for CLEC18A Gene

genes like me logo Genes that share phenotypes with CLEC18A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC18A

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC18A Gene

Localization for CLEC18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC18A Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC18A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
plasma membrane 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for CLEC18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,IDA 26170455
GO:0005768 endosome TAS 26170455
GO:0005783 endoplasmic reticulum TAS 26170455
GO:0005794 Golgi apparatus TAS 26170455
genes like me logo Genes that share ontologies with CLEC18A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC18A Gene

Pathways & Interactions for CLEC18A Gene

PathCards logo

SuperPathways for CLEC18A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLEC18A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLEC18A Gene

Drugs & Compounds for CLEC18A Gene

No Compound Related Data Available

Transcripts for CLEC18A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC18A Gene

No ASD Table

Relevant External Links for CLEC18A Gene

GeneLoc Exon Structure for
CLEC18A
ECgene alternative splicing isoforms for
CLEC18A

Expression for CLEC18A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC18A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC18A Gene

This gene is overexpressed in Kidney - Cortex (x17.7) and Artery - Aorta (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of CLEC18A Gene:

CLEC18A

SOURCE GeneReport for Unigene cluster for CLEC18A Gene:

Hs.592064

mRNA Expression by UniProt/SwissProt for CLEC18A Gene:

A5D8T8-CL18A_HUMAN
Tissue specificity: Dectected in all cell lines tested and in peripheral blood cells.

Evidence on tissue expression from TISSUES for CLEC18A Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with CLEC18A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC18A Gene

Orthologs for CLEC18A Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC18A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC18A 33
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 33
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Clec18a 33
  • 63 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MRCL 33
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 33
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lon-1 33
  • 23 (a)
OneToMany
Species where no ortholog for CLEC18A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CLEC18A Gene

ENSEMBL:
Gene Tree for CLEC18A (if available)
TreeFam:
Gene Tree for CLEC18A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLEC18A: view image

Paralogs for CLEC18A Gene

(3) SIMAP similar genes for CLEC18A Gene using alignment to 3 proteins:

  • CL18A_HUMAN
  • F8W692_HUMAN
  • H3BNR9_HUMAN
genes like me logo Genes that share paralogs with CLEC18A: view

Variants for CLEC18A Gene

Sequence variations from dbSNP and Humsavar for CLEC18A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000491644 -- 69,967,317(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000570275 -- 69,952,801(+) C/T intron_variant
rs1001195522 -- 69,965,350(+) T/C/G genic_downstream_transcript_variant, intron_variant
rs1001995751 -- 69,966,531(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1002009958 -- 69,950,434(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC18A Gene

Variant ID Type Subtype PubMed ID
dgv2997n100 CNV loss 25217958
dgv2998n100 CNV gain 25217958
dgv2999n100 CNV loss 25217958
dgv3000n100 CNV gain+loss 25217958
dgv485n67 CNV loss 20364138
dgv848e212 CNV loss 25503493
dgv849e212 CNV gain 25503493
esv25670 CNV gain+loss 19812545
esv2714669 CNV deletion 23290073
esv2758652 CNV gain+loss 17122850
esv2762188 CNV gain+loss 21179565
esv3428880 CNV duplication 20981092
nsv1056602 CNV gain 25217958
nsv1071293 CNV deletion 25765185
nsv1110289 CNV duplication 24896259
nsv1124741 CNV duplication 24896259
nsv1151295 CNV duplication 26484159
nsv1853 CNV deletion 18451855
nsv428328 CNV gain+loss 18775914
nsv509630 CNV insertion 20534489
nsv9452 CNV loss 18304495
nsv974827 CNV duplication 23825009

Variation tolerance for CLEC18A Gene

Gene Damage Index Score: 11.26; 92.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC18A Gene

Disorders for CLEC18A Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLEC18A Gene - From: DISEASES

Disorder Aliases PubMed IDs
cellular myxoid liposarcoma
  • round cell liposarcoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CLEC18A

genes like me logo Genes that share disorders with CLEC18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC18A Gene

Publications for CLEC18A Gene

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. (PMID: 26170455) Huang YL … Hsieh SL (The Journal of biological chemistry 2015) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 56
  4. The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection. (PMID: 30055605) Tsai TY … Hsieh SL (Journal of biomedical science 2018) 3 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for CLEC18A Gene

Sources for CLEC18A Gene