Aliases for CLEC17A Gene

Aliases for CLEC17A Gene

  • C-Type Lectin Domain Containing 17A 2 3 5
  • C-Type Lectin Domain Family 17, Member A 2 3 4
  • Prolectin 2 3 4
  • C-Type Lectin Domain Family 17 Member A 2 3

External Ids for CLEC17A Gene

Previous GeneCards Identifiers for CLEC17A Gene

  • GC19P014559
  • GC19P014565
  • GC19P014693
  • GC19P014264

Summaries for CLEC17A Gene

GeneCards Summary for CLEC17A Gene

CLEC17A (C-Type Lectin Domain Containing 17A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include mannose binding and fucose binding. An important paralog of this gene is FCER2.

UniProtKB/Swiss-Prot Summary for CLEC17A Gene

  • Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.

Additional gene information for CLEC17A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLEC17A Gene

Genomics for CLEC17A Gene

GeneHancer (GH) Regulatory Elements for CLEC17A Gene

Promoters and enhancers for CLEC17A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014582 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 500.7 +0.8 770 1.9 SIN3A EP300 POLR2A RELA TRIM22 BCL11A TCF12 CBFB USF2 SRF CLEC17A RF00017-2845 RN7SL337P lnc-TECR-2
GH19J014580 Enhancer 1.2 Ensembl ENCODE dbSUPER 6.5 -3.0 -3013 3 EP300 TRIM22 RBM25 MIER1 BCL11A NCOR1 RELA ZNF316 NFIC NKRF CLEC17A RF00017-2844
GH19J014573 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 0.4 -8.4 -8393 1.4 ZNF217 CTCF NRF1 SP1 ZIC2 REST ZBTB25 MYC RCOR1 RAD21 RF00017-2844 ZNF333 CLEC17A
GH19J014585 Enhancer 0.9 ENCODE dbSUPER 0.7 +2.4 2390 0.2 TRIM22 ARNT MEF2B NBN BATF IKZF1 NR2F1 NFATC3 ATF2 TBX21 RF00017-2845 RF00017-2846 RN7SL337P lnc-TECR-2 CLEC17A
GH19J014577 Enhancer 0.9 Ensembl dbSUPER 0.7 -4.9 -4854 0.7 ZNF316 USF2 TARDBP MEF2B NBN SMARCA5 BCOR USF1 ZNF335 EBF1 CLEC17A RF00017-2844
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC17A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLEC17A

Top Transcription factor binding sites by QIAGEN in the CLEC17A gene promoter:
  • AML1a
  • ER-alpha
  • NF-kappaB
  • NF-kappaB1
  • Pbx1a
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • STAT5A
  • ZID

Genomic Locations for CLEC17A Gene

Genomic Locations for CLEC17A Gene
chr19:14,582,914-14,611,157
(GRCh38/hg38)
Size:
28,244 bases
Orientation:
Plus strand
chr19:14,693,896-14,721,969
(GRCh37/hg19)
Size:
28,074 bases
Orientation:
Plus strand

Genomic View for CLEC17A Gene

Genes around CLEC17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC17A Gene

Proteins for CLEC17A Gene

  • Protein details for CLEC17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS10-CL17A_HUMAN
    Recommended name:
    C-type lectin domain family 17, member A
    Protein Accession:
    Q6ZS10
    Secondary Accessions:
    • A8MX68
    • B2RTX0
    • B7ZMM4

    Protein attributes for CLEC17A Gene

    Size:
    378 amino acids
    Molecular mass:
    42935 Da
    Quaternary structure:
    • Oligomer; disulfide-linked.
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=EAW84437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC17A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC17A Gene

Post-translational modifications for CLEC17A Gene

  • Phosphorylated on tyrosine residues.
  • Glycosylation at Asn215, Asn237, and Asn285
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLEC17A Gene

Domains & Families for CLEC17A Gene

Gene Families for CLEC17A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLEC17A Gene

Suggested Antigen Peptide Sequences for CLEC17A Gene

GenScript: Design optimal peptide antigens:
  • Prolectin (CL17A_HUMAN)
genes like me logo Genes that share domains with CLEC17A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CLEC17A Gene

Function for CLEC17A Gene

Molecular function for CLEC17A Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.

Phenotypes From GWAS Catalog for CLEC17A Gene

Gene Ontology (GO) - Molecular Function for CLEC17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005537 mannose binding IDA 19419970
GO:0030246 carbohydrate binding IEA --
GO:0042806 fucose binding IDA 19419970
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CLEC17A: view
genes like me logo Genes that share phenotypes with CLEC17A: view

miRNA for CLEC17A Gene

miRTarBase miRNAs that target CLEC17A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC17A Gene

Localization for CLEC17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC17A Gene

Membrane; Single-pass type II membrane protein. Note=In fibroblasts, expressed on the cell surface. {ECO:0000269 PubMed:19419970}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC17A gene
Compartment Confidence
plasma membrane 2
extracellular 1
nucleus 1
endoplasmic reticulum 1
cytosol 0

Gene Ontology (GO) - Cellular Components for CLEC17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 19419970
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC17A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC17A Gene

Pathways & Interactions for CLEC17A Gene

PathCards logo

SuperPathways for CLEC17A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLEC17A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLEC17A Gene

Drugs & Compounds for CLEC17A Gene

No Compound Related Data Available

Transcripts for CLEC17A Gene

mRNA/cDNA for CLEC17A Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC17A Gene

No ASD Table

Relevant External Links for CLEC17A Gene

GeneLoc Exon Structure for
CLEC17A

Expression for CLEC17A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC17A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC17A Gene

This gene is overexpressed in Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for CLEC17A Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC17A Gene



Protein tissue co-expression partners for CLEC17A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLEC17A

SOURCE GeneReport for Unigene cluster for CLEC17A Gene:

Hs.567933

mRNA Expression by UniProt/SwissProt for CLEC17A Gene:

Q6ZS10-CL17A_HUMAN
Tissue specificity: Expressed on dividing B-cells of germinal centers in various tissues, including lymph nodes, tonsils, stomach, intestine, appendix and spleen.

Evidence on tissue expression from TISSUES for CLEC17A Gene

  • Spleen(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with CLEC17A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC17A Gene

Orthologs for CLEC17A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC17A 31 30
  • 99.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC17A 31 30
  • 84.58 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 42 (a)
OneToMany
-- 31
  • 38 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 27 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC426106 30
  • 48.68 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 36 (a)
ManyToMany
Species where no ortholog for CLEC17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC17A Gene

ENSEMBL:
Gene Tree for CLEC17A (if available)
TreeFam:
Gene Tree for CLEC17A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLEC17A: view image

Paralogs for CLEC17A Gene

(6) SIMAP similar genes for CLEC17A Gene using alignment to 3 proteins:

  • CL17A_HUMAN
  • F8W1T8_HUMAN
  • H9KVA4_HUMAN
genes like me logo Genes that share paralogs with CLEC17A: view

Variants for CLEC17A Gene

Additional dbSNP identifiers (rs#s) for CLEC17A Gene

Structural Variations from Database of Genomic Variants (DGV) for CLEC17A Gene

Variant ID Type Subtype PubMed ID
esv25063 CNV loss 19812545
esv2650508 CNV insertion 19546169
esv2718215 CNV deletion 23290073
esv2718216 CNV deletion 23290073
esv3352877 CNV duplication 20981092
esv3381235 CNV duplication 20981092
esv3643748 CNV loss 21293372
esv3893167 CNV gain 25118596
esv7099 CNV loss 19470904
nsv820025 CNV insertion 19587683

Variation tolerance for CLEC17A Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC17A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLEC17A Gene

Disorders for CLEC17A Gene

Additional Disease Information for CLEC17A

No disorders were found for CLEC17A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC17A Gene

Publications for CLEC17A Gene

  1. Prolectin, a glycan-binding receptor on dividing B cells in germinal centers. (PMID: 19419970) Graham SA … Drickamer K (The Journal of biological chemistry 2009) 2 3 4 54
  2. Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through CLEC17A (Prolectin). (PMID: 26908442) Breiman A … Le Pendu J (Oncotarget 2016) 3 54
  3. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PMID: 23453885) Cross-Disorder Group of the Psychiatric Genomics Consortium (Lancet (London, England) 2013) 3 54
  4. The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. (PMID: 21822214) Oellerich T … Wienands J (The EMBO journal 2011) 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for CLEC17A Gene

Sources for CLEC17A Gene