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Aliases for CLEC17A Gene

Aliases for CLEC17A Gene

  • C-Type Lectin Domain Containing 17A 2 3 5
  • C-Type Lectin Domain Family 17, Member A 2 3 4
  • Prolectin 2 3 4
  • C-Type Lectin Domain Family 17 Member A 2 3

External Ids for CLEC17A Gene

Previous GeneCards Identifiers for CLEC17A Gene

  • GC19P014559
  • GC19P014693
  • GC19P014264

Summaries for CLEC17A Gene

GeneCards Summary for CLEC17A Gene

CLEC17A (C-Type Lectin Domain Containing 17A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include mannose binding and fucose binding. An important paralog of this gene is FCER2.

UniProtKB/Swiss-Prot for CLEC17A Gene

  • Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.

Additional gene information for CLEC17A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC17A Gene

Genomics for CLEC17A Gene

GeneHancer (GH) Regulatory Elements for CLEC17A Gene

Promoters and enhancers for CLEC17A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014582 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.8 770 1.9 NKRF POLR2A ZNF687 RELA CREM MLLT1 ZBED1 IKZF1 ZBTB33 BACH1 CLEC17A RN7SL337P
GH19J014584 Promoter/Enhancer 0.8 Ensembl dbSUPER 600.7 +2.0 1987 0.2 MLLT1 CLEC17A RN7SL337P RN7SL842P
GH19J014580 Enhancer 0.8 ENCODE 6.5 -2.1 -2050 0.2 CBFA2T2 NKRF CREM ZBED1 IKZF1 IKZF2 ZNF143 LARP7 RELA TRIM22 CLEC17A NDUFB7
GH19J014587 Enhancer 0.7 Ensembl dbSUPER 6.2 +5.8 5786 3.4 IKZF1 IKZF2 PKNOX1 HDGF FOS TARDBP RN7SL842P CLEC17A C19orf57 ENSG00000269378
GH19J014576 Enhancer 0.7 dbSUPER 6.1 -5.0 -4961 3.8 ZKSCAN8 ZNF121 IKZF1 PRDM10 IKZF2 ZNF24 PKNOX1 ZNF316 EED RUNX3 ZNF333 CLEC17A NDUFB7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC17A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLEC17A gene promoter:
  • AML1a
  • ER-alpha
  • NF-kappaB
  • NF-kappaB1
  • Pbx1a
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • STAT5A
  • ZID

Genomic Locations for CLEC17A Gene

Genomic Locations for CLEC17A Gene
chr19:14,582,914-14,611,157
(GRCh38/hg38)
Size:
28,244 bases
Orientation:
Plus strand
chr19:14,693,896-14,721,969
(GRCh37/hg19)
Size:
28,074 bases
Orientation:
Plus strand

Genomic View for CLEC17A Gene

Genes around CLEC17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC17A Gene

Proteins for CLEC17A Gene

  • Protein details for CLEC17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS10-CL17A_HUMAN
    Recommended name:
    C-type lectin domain family 17, member A
    Protein Accession:
    Q6ZS10
    Secondary Accessions:
    • A8MX68
    • B2RTX0
    • B7ZMM4

    Protein attributes for CLEC17A Gene

    Size:
    378 amino acids
    Molecular mass:
    42935 Da
    Quaternary structure:
    • Oligomer; disulfide-linked.
    SequenceCaution:
    • Sequence=EAW84437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC17A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC17A Gene

Post-translational modifications for CLEC17A Gene

  • Phosphorylated on tyrosine residues.
  • Glycosylation at posLast=215215, posLast=237237, and posLast=285285
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLEC17A Gene

Domains & Families for CLEC17A Gene

Gene Families for CLEC17A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLEC17A Gene

Suggested Antigen Peptide Sequences for CLEC17A Gene

GenScript: Design optimal peptide antigens:
  • Prolectin (CL17A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLEC17A: view

No data available for UniProtKB/Swiss-Prot for CLEC17A Gene

Function for CLEC17A Gene

Molecular function for CLEC17A Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.

Phenotypes From GWAS Catalog for CLEC17A Gene

Gene Ontology (GO) - Molecular Function for CLEC17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005537 mannose binding IDA 19419970
GO:0030246 carbohydrate binding IEA --
GO:0042806 fucose binding IDA 19419970
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CLEC17A: view
genes like me logo Genes that share phenotypes with CLEC17A: view

Animal Model Products

CRISPR Products

miRNA for CLEC17A Gene

miRTarBase miRNAs that target CLEC17A

Clone Products

  • Applied Biological Materials (abm): Clones for CLEC17A - Now 50% OFF >
  • * CLEC17A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CLEC17A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC17A Gene

Localization for CLEC17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC17A Gene

Membrane; Single-pass type II membrane protein. Note=In fibroblasts, expressed on the cell surface. {ECO:0000269 PubMed:19419970}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC17A gene
Compartment Confidence
plasma membrane 2
nucleus 0
cytosol 0

Gene Ontology (GO) - Cellular Components for CLEC17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 19419970
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC17A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC17A Gene

Pathways & Interactions for CLEC17A Gene

PathCards logo

SuperPathways for CLEC17A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLEC17A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLEC17A Gene

Drugs & Compounds for CLEC17A Gene

No Compound Related Data Available

Transcripts for CLEC17A Gene

mRNA/cDNA for CLEC17A Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for CLEC17A Gene

C-type lectin domain family 17, member A:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CLEC17A - Now 50% OFF >
  • * CLEC17A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CLEC17A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC17A Gene

No ASD Table

Relevant External Links for CLEC17A Gene

GeneLoc Exon Structure for
CLEC17A
ECgene alternative splicing isoforms for
CLEC17A

Expression for CLEC17A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC17A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC17A Gene

This gene is overexpressed in Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for CLEC17A Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC17A Gene



Protein tissue co-expression partners for CLEC17A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLEC17A Gene:

CLEC17A

SOURCE GeneReport for Unigene cluster for CLEC17A Gene:

Hs.567933

mRNA Expression by UniProt/SwissProt for CLEC17A Gene:

Q6ZS10-CL17A_HUMAN
Tissue specificity: Expressed on dividing B-cells of germinal centers in various tissues, including lymph nodes, tonsils, stomach, intestine, appendix and spleen.

Evidence on tissue expression from TISSUES for CLEC17A Gene

  • Spleen(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with CLEC17A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC17A Gene

Orthologs for CLEC17A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC17A 35 34
  • 99.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC17A 35 34
  • 84.58 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 27 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC426106 34
  • 48.68 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
ManyToMany
Species where no ortholog for CLEC17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC17A Gene

ENSEMBL:
Gene Tree for CLEC17A (if available)
TreeFam:
Gene Tree for CLEC17A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLEC17A: view image

Paralogs for CLEC17A Gene

(6) SIMAP similar genes for CLEC17A Gene using alignment to 3 proteins:

  • CL17A_HUMAN
  • F8W1T8_HUMAN
  • H9KVA4_HUMAN
genes like me logo Genes that share paralogs with CLEC17A: view

Variants for CLEC17A Gene

Sequence variations from dbSNP and Humsavar for CLEC17A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000087526 -- 14,609,399(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000109830 -- 14,579,227(+) G/A upstream_transcript_variant
rs1000156985 -- 14,582,027(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000335974 -- 14,589,547(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000436052 -- 14,594,884(+) TTTTTTTT/TTTTTTT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC17A Gene

Variant ID Type Subtype PubMed ID
esv25063 CNV loss 19812545
esv2650508 CNV insertion 19546169
esv2718215 CNV deletion 23290073
esv2718216 CNV deletion 23290073
esv3352877 CNV duplication 20981092
esv3381235 CNV duplication 20981092
esv3643748 CNV loss 21293372
esv3893167 CNV gain 25118596
esv7099 CNV loss 19470904
nsv820025 CNV insertion 19587683

Variation tolerance for CLEC17A Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC17A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC17A Gene

Disorders for CLEC17A Gene

Additional Disease Information for CLEC17A

No disorders were found for CLEC17A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC17A Gene

Publications for CLEC17A Gene

  1. Prolectin, a glycan-binding receptor on dividing B cells in germinal centers. (PMID: 19419970) Graham SA … Drickamer K (The Journal of biological chemistry 2009) 2 3 4 58
  2. Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through CLEC17A (Prolectin). (PMID: 26908442) Breiman A … Le Pendu J (Oncotarget 2016) 3 58
  3. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PMID: 23453885) Cross-Disorder Group of the Psychiatric Genomics Consortium (Lancet (London, England) 2013) 3 58
  4. The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. (PMID: 21822214) Oellerich T … Wienands J (The EMBO journal 2011) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for CLEC17A Gene

Sources for CLEC17A Gene

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