Aliases for CLEC16A Gene
External Ids for CLEC16A Gene
Previous HGNC Symbols for CLEC16A Gene
Previous GeneCards Identifiers for CLEC16A Gene
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for CLEC16A Gene
CLEC16A (C-Type Lectin Domain Containing 16A) is a Protein Coding gene. Diseases associated with CLEC16A include Selective Immunoglobulin Deficiency Disease and Interleukin-7 Receptor Alpha Deficiency.
UniProtKB/Swiss-Prot for CLEC16A Gene
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.