This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in ... See more...

Aliases for CLEC14A Gene

Aliases for CLEC14A Gene

  • C-Type Lectin Domain Containing 14A 2 3 5
  • C-Type Lectin Domain Family 14 Member A 2 3 4
  • Epidermal Growth Factor Receptor 5 3 4
  • C14orf27 3 4
  • EGFR-5 3 4
  • ClECT And EGF-Like Domain Containing Protein 3
  • C-Type Lectin Domain Family 14, Member A 2
  • Chromosome 14 Open Reading Frame 27 2
  • CLEC14A 5
  • EGFR5 4
  • CEG1 3

External Ids for CLEC14A Gene

Previous HGNC Symbols for CLEC14A Gene

  • C14orf27

Previous GeneCards Identifiers for CLEC14A Gene

  • GC14M037794
  • GC14M038723
  • GC14M018838

Summaries for CLEC14A Gene

Entrez Gene Summary for CLEC14A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]

GeneCards Summary for CLEC14A Gene

CLEC14A (C-Type Lectin Domain Containing 14A) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p70S6K Signaling. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD93.

Additional gene information for CLEC14A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLEC14A Gene

Genomics for CLEC14A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CLEC14A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J038251 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.6 +2.2 2229 8.5 CTCF KDM1A EZH2 CEBPB FOXA2 JUN MAFF FOS MAFK JUND piR-44391 CLEC14A SSTR1 ENSG00000259072 LOC112268136 HSALNG0100724
GH14J038206 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 10.8 +46.4 46367 5.7 REST ZIC2 SP1 POLR2A EZH2 ZNF561 CTCF ZNF207 RAD21 SMARCC1 HSALNG0100724 SSTR1 PNN CLEC14A piR-44391 LOC112268136
GH14J038289 Enhancer 0.9 Ensembl ENCODE 16.5 -35.0 -35008 4.2 PHB2 CEBPA TCF7 TCF7L2 CEBPB FOS CHD2 FOXA2 JUN RCOR1 CLEC14A SSTR1 SEC23A-AS1 HSALNG0100729 piR-31534-190 ENSG00000259072 LOC112268136 SEC23A
GH14J038197 Enhancer 1 Ensembl ENCODE dbSUPER 10.4 +56.8 56813 3 CTCF SP1 POLR2A BRCA1 CEBPB CHD2 JUN CREB1 JUND MAX CLEC14A SSTR1 lnc-CLEC14A-3 ENSG00000258649 FOXA1
GH14J038286 Enhancer 0.8 Ensembl ENCODE 11.9 -30.2 -30208 1.4 CEBPB BRCA1 CHD2 JUN RCOR1 JUND MAX EP300 RFX5 SMC3 HSALNG0100729 CLEC14A LOC112268136 ENSG00000259072 piR-31534-190 SEC23A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC14A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLEC14A

Top Transcription factor binding sites by QIAGEN in the CLEC14A gene promoter:
  • AP-2rep
  • CUTL1
  • MZF-1
  • POU2F1
  • POU2F1a
  • RSRFC4

Genomic Locations for CLEC14A Gene

Genomic Locations for CLEC14A Gene
chr14:38,254,000-38,256,093
(GRCh38/hg38)
Size:
2,094 bases
Orientation:
Minus strand
chr14:38,723,308-38,725,574
(GRCh37/hg19)
Size:
2,267 bases
Orientation:
Minus strand

Genomic View for CLEC14A Gene

Genes around CLEC14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC14A Gene

Proteins for CLEC14A Gene

  • Protein details for CLEC14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T13-CLC14_HUMAN
    Recommended name:
    C-type lectin domain family 14 member A
    Protein Accession:
    Q86T13
    Secondary Accessions:
    • Q695G9
    • Q6PWT6
    • Q8N5V5

    Protein attributes for CLEC14A Gene

    Size:
    490 amino acids
    Molecular mass:
    51636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC14A Gene

Post-translational modifications for CLEC14A Gene

  • Glycosylation at Asn189 and Asn381
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC14A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC14A Gene

Domains & Families for CLEC14A Gene

Gene Families for CLEC14A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLEC14A Gene

Suggested Antigen Peptide Sequences for CLEC14A Gene

GenScript: Design optimal peptide antigens:
  • Epidermal growth factor receptor 5 (CLC14_HUMAN)
genes like me logo Genes that share domains with CLEC14A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CLEC14A Gene

Function for CLEC14A Gene

Phenotypes From GWAS Catalog for CLEC14A Gene

Gene Ontology (GO) - Molecular Function for CLEC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27991863
GO:0030246 carbohydrate binding IEA --
GO:0050840 extracellular matrix binding IBA 21873635
GO:1990430 extracellular matrix protein binding IDA 25745997
genes like me logo Genes that share ontologies with CLEC14A: view
genes like me logo Genes that share phenotypes with CLEC14A: view

Animal Models for CLEC14A Gene

MGI Knock Outs for CLEC14A:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC14A

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC14A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC14A Gene

Localization for CLEC14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC14A Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC14A gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
peroxisome 1
nucleus 1
cytosol 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLEC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IDA 25745997
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0062023 collagen-containing extracellular matrix HDA 23979707
genes like me logo Genes that share ontologies with CLEC14A: view

Pathways & Interactions for CLEC14A Gene

PathCards logo

SuperPathways for CLEC14A Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.72
.66
.65
.62
.61
.60
.57
2 CREB Pathway
.68
.63
3 PAK Pathway
.56
.56
4 p70S6K Signaling
.60
.60
5 Phospholipase-C Pathway
.56
.56
genes like me logo Genes that share pathways with CLEC14A: view

Pathways by source for CLEC14A Gene

22 Qiagen pathways for CLEC14A Gene
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Antioxidant Action of Vitamin-C
  • Apoptotic Pathways in Synovial Fibroblasts
  • Breast Cancer Regulation by Stathmin1

Gene Ontology (GO) - Biological Process for CLEC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002042 cell migration involved in sprouting angiogenesis IEA --
GO:0016477 cell migration IBA 21873635
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway IMP 27991863
GO:0036325 vascular endothelial growth factor receptor-3 signaling pathway IMP 27991863
genes like me logo Genes that share ontologies with CLEC14A: view

No data available for SIGNOR curated interactions for CLEC14A Gene

Drugs & Compounds for CLEC14A Gene

(1) Drugs for CLEC14A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Resveratrol Investigational Pharma Target Cyclooxygenase inhibitor 156
genes like me logo Genes that share compounds with CLEC14A: view

Transcripts for CLEC14A Gene

mRNA/cDNA for CLEC14A Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC14A

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC14A Gene

No ASD Table

Relevant External Links for CLEC14A Gene

GeneLoc Exon Structure for
CLEC14A

Expression for CLEC14A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC14A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLEC14A Gene

This gene is overexpressed in Lung (20.9), Heart (17.4), Urine (11.5), and Fetal heart (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC14A Gene



Protein tissue co-expression partners for CLEC14A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLEC14A

SOURCE GeneReport for Unigene cluster for CLEC14A Gene:

Hs.525307

Evidence on tissue expression from TISSUES for CLEC14A Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Blood(2.5)
  • Heart(2.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with CLEC14A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC14A Gene

Orthologs for CLEC14A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC14A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CLEC14A 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CLEC14A 30 31
  • 86.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CLEC14A 30 31
  • 81.97 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Clec14a 30
  • 74.41 (n)
Mouse
(Mus musculus)
Mammalia Clec14a 30 17 31
  • 73.7 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CLEC14A 31
  • 32 (a)
OneToOne
Species where no ortholog for CLEC14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CLEC14A Gene

ENSEMBL:
Gene Tree for CLEC14A (if available)
TreeFam:
Gene Tree for CLEC14A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLEC14A: view image

Paralogs for CLEC14A Gene

Paralogs for CLEC14A Gene

genes like me logo Genes that share paralogs with CLEC14A: view

Variants for CLEC14A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLEC14A Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
790141 Benign: not provided 38,254,838(-) G/A SYNONYMOUS_VARIANT
790683 Benign: not provided 38,255,200(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CLEC14A Gene

Structural Variations from Database of Genomic Variants (DGV) for CLEC14A Gene

Variant ID Type Subtype PubMed ID
nsv456210 CNV gain 19166990
nsv564399 CNV gain 21841781
nsv832773 CNV loss 17160897

Variation tolerance for CLEC14A Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC14A Gene

Disorders for CLEC14A Gene

Additional Disease Information for CLEC14A

No disorders were found for CLEC14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC14A Gene

Publications for CLEC14A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4
  3. [Cloning and characterization of a novel human ceg1 gene cDNA]. (PMID: 15636369) Fu JQ … Li YP (Shi yan sheng wu xue bao 2004) 4 23
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for CLEC14A Gene

  • Boster Bio Antibodies for CLEC14A
  • Boster Bio ELISA Kits for CLEC14A
  • Biorbyt antibodies for CLEC14A

Sources for CLEC14A Gene