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Aliases for CLEC12B Gene

Aliases for CLEC12B Gene

  • C-Type Lectin Domain Family 12 Member B 2 3 5
  • Macrophage Antigen H 3 4
  • Testis Secretory Sperm-Binding Protein Li 205a 3
  • C-Type Lectin Domain Family 12, Member B 2
  • UNQ5782 3

External Ids for CLEC12B Gene

Previous GeneCards Identifiers for CLEC12B Gene

  • GC12P010055
  • GC12P010125

Summaries for CLEC12B Gene

GeneCards Summary for CLEC12B Gene

CLEC12B (C-Type Lectin Domain Family 12 Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC12A.

UniProtKB/Swiss-Prot for CLEC12B Gene

  • Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Additional gene information for CLEC12B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC12B Gene

Genomics for CLEC12B Gene

GeneHancer (GH) Regulatory Elements for CLEC12B Gene

Promoters and enhancers for CLEC12B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I010010 Promoter 0.5 EPDnew 550.8 +1.6 1569 0.1 CLEC12B CLEC1B
GH12I009970 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.8 -36.5 -36546 4.2 POLR2A REST CLEC12A OLR1 CLEC12B CLEC7A CLEC1B GABARAPL1 CLEC2B CLEC12A-AS1
GH12I010030 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 11 +22.5 22522 2.7 STAT1 JUN MAFG BACH1 CBFA2T3 POLR2A GABPB1 NFE2 EMSY CLEC9A LOC102724020 CLEC7A CLEC12B TMEM52B OLR1 CLEC1A STYK1 LOC100421202
GH12I009948 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.4 -60.1 -60098 1.1 PKNOX1 BMI1 BATF IRF4 ATF7 ETV6 IKZF2 RUNX3 TRIM22 JUNB CLEC12A CLEC12B CLEC1B CLEC7A CLEC9A LOC102724020 CLEC12A-AS1 LINC02470
GH12I009947 Enhancer 0.8 ENCODE dbSUPER 11.4 -61.2 -61190 0.1 JUNB DPF2 BATF ATF2 IRF4 IKZF1 RUNX3 IKZF2 SPI1 CLEC12B CLEC1B CLEC7A CLEC9A LOC102724020 CLEC12A LINC02470
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLEC12B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLEC12B gene promoter:

Genomic Locations for CLEC12B Gene

Genomic Locations for CLEC12B Gene
chr12:10,009,047-10,018,800
(GRCh38/hg38)
Size:
9,754 bases
Orientation:
Plus strand
chr12:10,163,226-10,171,399
(GRCh37/hg19)

Genomic View for CLEC12B Gene

Genes around CLEC12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC12B Gene

Proteins for CLEC12B Gene

  • Protein details for CLEC12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2HXU8-CL12B_HUMAN
    Recommended name:
    C-type lectin domain family 12 member B
    Protein Accession:
    Q2HXU8
    Secondary Accessions:
    • Q6UWF2
    • Q6ZRG0

    Protein attributes for CLEC12B Gene

    Size:
    276 amino acids
    Molecular mass:
    31616 Da
    Quaternary structure:
    • Homodimer. Interacts with PTPN6 and PTPN11.

    Alternative splice isoforms for CLEC12B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC12B Gene

Post-translational modifications for CLEC12B Gene

  • Glycosylation at posLast=9191, posLast=176176, and Asn237
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLEC12B Gene

Domains & Families for CLEC12B Gene

Gene Families for CLEC12B Gene

Suggested Antigen Peptide Sequences for CLEC12B Gene

Graphical View of Domain Structure for InterPro Entry

Q2HXU8

UniProtKB/Swiss-Prot:

CL12B_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
genes like me logo Genes that share domains with CLEC12B: view

Function for CLEC12B Gene

Molecular function for CLEC12B Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Phenotypes From GWAS Catalog for CLEC12B Gene

Gene Ontology (GO) - Molecular Function for CLEC12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019903 protein phosphatase binding IPI 17562706
GO:0030246 carbohydrate binding IEA --
GO:0030547 receptor inhibitor activity IMP 17562706
genes like me logo Genes that share ontologies with CLEC12B: view
genes like me logo Genes that share phenotypes with CLEC12B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC12B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC12B Gene

Localization for CLEC12B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC12B Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC12B gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CLEC12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane IMP 17562706
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043234 protein complex IMP 17562706
genes like me logo Genes that share ontologies with CLEC12B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC12B Gene

Pathways & Interactions for CLEC12B Gene

SuperPathways for CLEC12B Gene

No Data Available

Interacting Proteins for CLEC12B Gene

Gene Ontology (GO) - Biological Process for CLEC12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002769 natural killer cell inhibitory signaling pathway IMP 17562706
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity IMP 17562706
GO:2000272 negative regulation of receptor activity IMP 17562706
genes like me logo Genes that share ontologies with CLEC12B: view

No data available for Pathways by source and SIGNOR curated interactions for CLEC12B Gene

Drugs & Compounds for CLEC12B Gene

No Compound Related Data Available

Transcripts for CLEC12B Gene

Unigene Clusters for CLEC12B Gene

C-type lectin domain family 12, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC12B Gene

No ASD Table

Relevant External Links for CLEC12B Gene

GeneLoc Exon Structure for
CLEC12B
ECgene alternative splicing isoforms for
CLEC12B

Expression for CLEC12B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC12B Gene

This gene is overexpressed in Testis (x18.7) and Whole Blood (x15.0).

Protein differential expression in normal tissues from HIPED for CLEC12B Gene

This gene is overexpressed in Plasma (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLEC12B Gene



Protein tissue co-expression partners for CLEC12B Gene

NURSA nuclear receptor signaling pathways regulating expression of CLEC12B Gene:

CLEC12B

SOURCE GeneReport for Unigene cluster for CLEC12B Gene:

Hs.127937

mRNA Expression by UniProt/SwissProt for CLEC12B Gene:

Q2HXU8-CL12B_HUMAN
Tissue specificity: Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis.
genes like me logo Genes that share expression patterns with CLEC12B: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC12B Gene

Orthologs for CLEC12B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC12B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC12B 33 34
  • 98.54 (n)
dog
(Canis familiaris)
Mammalia LOC611402 33
  • 85.27 (n)
CLEC12B 34
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC12B 33 34
  • 85.14 (n)
mouse
(Mus musculus)
Mammalia Clec12b 33 16 34
  • 75.52 (n)
rat
(Rattus norvegicus)
Mammalia Clec12b 33
  • 74.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
OneToMany
Species where no ortholog for CLEC12B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC12B Gene

ENSEMBL:
Gene Tree for CLEC12B (if available)
TreeFam:
Gene Tree for CLEC12B (if available)

Paralogs for CLEC12B Gene

Paralogs for CLEC12B Gene

(7) SIMAP similar genes for CLEC12B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLEC12B: view

Variants for CLEC12B Gene

Sequence variations from dbSNP and Humsavar for CLEC12B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000533348 -- 10,011,658(+) T/C intron_variant
rs1000685912 -- 10,006,182(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000722848 -- 10,009,573(+) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000990775 -- 10,011,894(+) G/A intron_variant
rs1001158510 -- 10,009,349(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC12B Gene

Variant ID Type Subtype PubMed ID
dgv1374n100 CNV gain 25217958
esv9698 OTHER inversion 19470904

Variation tolerance for CLEC12B Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.39; 90.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC12B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC12B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC12B Gene

Disorders for CLEC12B Gene

Additional Disease Information for CLEC12B

No disorders were found for CLEC12B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC12B Gene

Publications for CLEC12B Gene

  1. Identification of CLEC12B, an inhibitory receptor on myeloid cells. (PMID: 17562706) Hoffmann SC … Watzl C (The Journal of biological chemistry 2007) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy. (PMID: 23834954) Kobayashi D … Fukuda K (Molecular pain 2013) 3 58
  4. Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis. (PMID: 24091439) Kulkarni YM … Liu J (The Analyst 2013) 3 58
  5. Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease. (PMID: 24058526) Bhatnagar P … Arking DE (PloS one 2013) 3 58

Products for CLEC12B Gene

Sources for CLEC12B Gene

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