This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two tra... See more...

Aliases for CLEC10A Gene

Aliases for CLEC10A Gene

  • C-Type Lectin Domain Containing 10A 2 3 5
  • C-Type Lectin Domain Family 10 Member A 2 3 4
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 14 (Macrophage-Derived) 2 3
  • Macrophage Lectin 2 (Calcium Dependent) 2 3
  • CLECSF13 3 4
  • CLECSF14 3 4
  • HML 3 4
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 13 (Macrophage-Derived) 3
  • C-Type Lectin Domain Family 10, Member A 2
  • C-Type Lectin Superfamily Member 14 4
  • Macrophage Lectin 2 4
  • CD301 Antigen 4
  • CD301 3
  • HML2 3
  • MGL 3

External Ids for CLEC10A Gene

Previous HGNC Symbols for CLEC10A Gene

  • CLECSF13
  • CLECSF14

Previous GeneCards Identifiers for CLEC10A Gene

  • GC17M006919
  • GC17M006923
  • GC17M006977
  • GC17M006871

Summaries for CLEC10A Gene

Entrez Gene Summary for CLEC10A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC10A Gene

CLEC10A (C-Type Lectin Domain Containing 10A) is a Protein Coding gene. Among its related pathways are CLEC7A (Dectin-1) signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ASGR1.

UniProtKB/Swiss-Prot Summary for CLEC10A Gene

  • Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.

Gene Wiki entry for CLEC10A Gene

Additional gene information for CLEC10A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLEC10A Gene

Genomics for CLEC10A Gene

GeneHancer (GH) Regulatory Elements for CLEC10A Gene

Promoters and enhancers for CLEC10A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007080 Promoter 0.4 EPDnew 500.7 +0.3 330 0.1 POLR2A CLEC10A lnc-ASGR2-1
GH17J007081 Promoter 0.4 Ensembl 500.7 +0.1 100 0.2 POLR2A CLEC10A lnc-ASGR2-1
GH17J007078 Enhancer 0.2 Ensembl 500.7 +2.0 2000 0.4 CLEC10A lnc-ASGR2-1 lnc-CLEC10A-1
GH17J007010 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13 +63.1 63100 14.2 RXRA FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G RNASEK BCL6B C17orf49 ENSG00000267047 MIR195 MIR497 DVL2 ENSG00000262089 NLGN2 SNORD10
GH17J007130 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 15.5 -51.6 -51591 3.9 CTCF SP1 EP300 TCF7 RELA RCOR1 POLR2A HDAC2 BCL11A NR2F2 LOC105371512 piR-31655-002 CLEC10A SLC16A11 ASGR1 BCL6B EIF5A RPL7AP64 TRAPPC1 CD68
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC10A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLEC10A

Top Transcription factor binding sites by QIAGEN in the CLEC10A gene promoter:
  • Arnt
  • Lmo2
  • MyoD
  • NF-1/L
  • Pax-2
  • Pax-2a
  • Pax-2b
  • PPAR-gamma1
  • PPAR-gamma2
  • Spz1

Genomic Locations for CLEC10A Gene

Genomic Locations for CLEC10A Gene
chr17:7,074,537-7,080,601
(GRCh38/hg38)
Size:
6,065 bases
Orientation:
Minus strand
chr17:6,977,856-6,983,626
(GRCh37/hg19)
Size:
5,771 bases
Orientation:
Minus strand

Genomic View for CLEC10A Gene

Genes around CLEC10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC10A Gene

Proteins for CLEC10A Gene

  • Protein details for CLEC10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUN9-CLC10_HUMAN
    Recommended name:
    C-type lectin domain family 10 member A
    Protein Accession:
    Q8IUN9
    Secondary Accessions:
    • A8K8J8
    • Q14538
    • Q6PIW3

    Protein attributes for CLEC10A Gene

    Size:
    316 amino acids
    Molecular mass:
    35446 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLEC10A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC10A Gene

Post-translational modifications for CLEC10A Gene

  • Glycosylation at Asn78 and Asn173
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLEC10A Gene

Domains & Families for CLEC10A Gene

Gene Families for CLEC10A Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CLEC10A Gene

Blocks:
  • Type II antifreeze protein signature
  • Hepatic lectin, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLEC10A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ78539, highly similar to Homo sapiens C-type lectin domain family 10, member A, mRNA (A8K7G0_HUMAN)
  • Macrophage lectin 2 (CLC10_HUMAN)
genes like me logo Genes that share domains with CLEC10A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CLEC10A Gene

Function for CLEC10A Gene

Molecular function for CLEC10A Gene

UniProtKB/Swiss-Prot Function:
Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.

Phenotypes From GWAS Catalog for CLEC10A Gene

Gene Ontology (GO) - Molecular Function for CLEC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding TAS,IEA --
genes like me logo Genes that share ontologies with CLEC10A: view
genes like me logo Genes that share phenotypes with CLEC10A: view

Animal Models for CLEC10A Gene

MGI Knock Outs for CLEC10A:
  • Mgl2 Mgl2<tm1b(KOMP)Wtsi>
  • Mgl2 Mgl2<tm1.1(HBEGF/EGFP)Aiwsk>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC10A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC10A Gene

Localization for CLEC10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC10A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC10A gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CLEC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC10A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC10A Gene

Pathways & Interactions for CLEC10A Gene

genes like me logo Genes that share pathways with CLEC10A: view

Pathways by source for CLEC10A Gene

Gene Ontology (GO) - Biological Process for CLEC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006897 endocytosis IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with CLEC10A: view

No data available for SIGNOR curated interactions for CLEC10A Gene

Drugs & Compounds for CLEC10A Gene

(2) Drugs for CLEC10A Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with CLEC10A: view

Transcripts for CLEC10A Gene

mRNA/cDNA for CLEC10A Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC10A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC10A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for CLEC10A Gene

GeneLoc Exon Structure for
CLEC10A

Expression for CLEC10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC10A Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for CLEC10A Gene

This gene is overexpressed in Heart (61.9) and Fetal Liver (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC10A Gene



Protein tissue co-expression partners for CLEC10A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLEC10A

SOURCE GeneReport for Unigene cluster for CLEC10A Gene:

Hs.54403

Evidence on tissue expression from TISSUES for CLEC10A Gene

  • Blood(4.3)
  • Nervous system(4.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CLEC10A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC10A Gene

Orthologs for CLEC10A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC10A 31 30
  • 98.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC10A 30
  • 77.03 (n)
-- 31
  • 22 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia CLEC10A 31 30
  • 71.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mgl2 17 31 30
  • 68.83 (n)
Clec10a 31
  • 51 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Clec10a 30
  • 68.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 35 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia clec10a 30
  • 52.83 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882127 30
  • 49.03 (n)
si:ch211-283g2.2 31
  • 31 (a)
ManyToMany
si:ch73-361h17.1 31
  • 30 (a)
ManyToMany
si:ch211-283g2.3 31
  • 24 (a)
ManyToMany
Species where no ortholog for CLEC10A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLEC10A Gene

ENSEMBL:
Gene Tree for CLEC10A (if available)
TreeFam:
Gene Tree for CLEC10A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLEC10A: view image

Paralogs for CLEC10A Gene

(18) SIMAP similar genes for CLEC10A Gene using alignment to 4 proteins:

  • CLC10_HUMAN
  • A8K7G0_HUMAN
  • I3NI09_HUMAN
  • J3KR22_HUMAN
genes like me logo Genes that share paralogs with CLEC10A: view

Variants for CLEC10A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLEC10A Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
711652 Benign: not provided 7,076,012(-) A/G MISSENSE_VARIANT
780396 Benign: not provided 7,075,798(-) G/C MISSENSE_VARIANT
rs16956478 - p.Arg73Lys
rs35101468 - p.Ala203Gly
rs35318160 - p.Thr100Met

Additional dbSNP identifiers (rs#s) for CLEC10A Gene

Structural Variations from Database of Genomic Variants (DGV) for CLEC10A Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2657406 CNV deletion 23128226
esv2669929 CNV deletion 23128226
esv5167 CNV loss 18987735
nsv1110711 CNV insertion 24896259
nsv1119455 CNV insertion 24896259
nsv1129588 CNV tandem duplication 24896259
nsv1142894 CNV tandem duplication 24896259
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781

Variation tolerance for CLEC10A Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC10A Gene

Disorders for CLEC10A Gene

Additional Disease Information for CLEC10A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CLEC10A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC10A Gene

Publications for CLEC10A Gene

  1. Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen. (PMID: 8598452) Suzuki N … Irimura T (Journal of immunology (Baltimore, Md. : 1950) 1996) 2 3 4 23 54
  2. Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP. (PMID: 19776380) Iijima M … Sobue G (Neurology 2009) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion. (PMID: 29755453) Heger L … Dudziak D (Frontiers in immunology 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for CLEC10A Gene

Sources for CLEC10A Gene