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Aliases for CLDND2 Gene
Aliases for CLDND2 Gene
External Ids for CLDND2 Gene
- HGNC: 28511
- Entrez Gene: 125875
- Ensembl: ENSG00000160318
- UniProtKB: Q8NHS1
Previous GeneCards Identifiers for CLDND2 Gene
- GC19M056563
- GC19M051870
- GC19M048202
Summaries for CLDND2 Gene
GeneCards Summary for CLDND2 Gene
CLDND2 (Claudin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is LIM2.
Additional gene information for CLDND2 Gene
- HGNC(28511)
- Entrez Gene(125875)
- Ensembl(ENSG00000160318)
- UniProtKB(Q8NHS1)
- Open Targets Platform(ENSG00000160318)
- Search for CLDND2 at DataMed
- Search for CLDND2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLDND2 Gene
Genomics for CLDND2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CLDND2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CLDND2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLDND2
- Top Transcription factor binding sites by QIAGEN in the CLDND2 gene promoter:
-
- CP2
- GATA-1
- HSF2
- NF-kappaB
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- Pax-6
Genomic Locations for CLDND2 Gene
Genomic Locations for CLDND2 Gene
- chr19:51,366,750-51,369,255
- (GRCh38/hg38)
- Size:
- 2,506 bases
- Orientation:
- Minus strand
- chr19:51,870,352-51,872,257
- (GRCh37/hg19)
- Size:
- 1,906 bases
- Orientation:
- Minus strand
Genomic View for CLDND2 Gene
Genes around CLDND2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.41 by HGNC
- 19q13.41 by Entrez Gene
- 19q13.41 by Ensembl
CLDND2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLDND2 Gene
Proteins for CLDND2 Gene
-
Protein details for CLDND2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NHS1-CLDN2_HUMAN
- Recommended name:
- Claudin domain-containing protein 2
- Protein Accession:
- Q8NHS1
Protein attributes for CLDND2 Gene
- Size:
- 167 amino acids
- Molecular mass:
- 17984 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CLDND2 Gene
Other Protein References for CLDND2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CLDND2
- Novus Biologicals Antibodies for CLDND2
- Invitrogen Antibodies for CLDND2 (AFLGC-CLDND2)
- antibodies-online: Show 13 available CLDND2 Antibodies ranked by validation data
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CLDND2
- Origene Custom Protein Services for CLDND2
-
Abcam proteins for CLDND2
No data available for DME Specific Peptides for CLDND2 Gene
Domains & Families for CLDND2 Gene
Gene Families for CLDND2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CLDND2 Gene
- InterPro:
- Blocks:
-
- PMP-22/EMP/MP20 family
- ProtoNet:
Suggested Antigen Peptide Sequences for CLDND2 Gene
- GenScript: Design optimal peptide antigens:
-
- Claudin domain-containing protein 2 (CLDN2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8NHS1- Family:
-
- Belongs to the PMP-22/EMP/MP20 family.
Function for CLDND2 Gene
Phenotypes From GWAS Catalog for CLDND2 Gene
Phenotypes for CLDND2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLDND2 - Select products 50% OFF >
- * CLDND2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CLDND2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLDND2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLDND2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLDND2
- Browse OriGene Inhibitory RNA Products For CLDND2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDND2
Clone Products
- Applied Biological Materials (abm): Clones for CLDND2 - Select products 50% OFF >
- * CLDND2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CLDND2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLDND2
Cell Line Products
-
Horizon Cell Lines for CLDND2
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDND2 Gene
Localization for CLDND2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLDND2 Gene
- Membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| cytosol | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for CLDND2 Gene
Interacting Proteins for CLDND2 Gene
Selected Interacting proteins:
Q8NHS1-CLDN2_HUMAN
ENSP00000291715
for CLDND2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CLDND2
No data available for Pathways by source and SIGNOR curated interactions for CLDND2 Gene
Transcripts for CLDND2 Gene
mRNA/cDNA for CLDND2 Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000291715 974 nts (view in UCSC)
- ENST00000593841 417 nts (view in UCSC)
- ENST00000601435 575 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLDND2 - Select products 50% OFF >
- * CLDND2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CLDND2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLDND2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLDND2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLDND2
- Browse OriGene Inhibitory RNA Products For CLDND2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDND2
Clone Products
- Applied Biological Materials (abm): Clones for CLDND2 - Select products 50% OFF >
- * CLDND2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CLDND2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLDND2
Relevant External Links for CLDND2 Gene
- GeneLoc Exon Structure for
- CLDND2
Expression for CLDND2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for CLDND2 Gene
This gene is overexpressed in Testis (x9.4) and Whole Blood (x4.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLDND2
SOURCE GeneReport for Unigene cluster for CLDND2 Gene:
Hs.720536Primer Products
-
OriGene qPCR primer pairs for CLDND2
-
OriGene qPCR primer pairs and template standards for CLDND2
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDND2 Gene
Orthologs for CLDND2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CLDND2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CLDND2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | CLDND2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cldnd2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cldnd2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CLDND2 31 |
|
OneToOne |
- Species where no ortholog for CLDND2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CLDND2 Gene
- ENSEMBL:
- Gene Tree for CLDND2 (if available)
- TreeFam:
- Gene Tree for CLDND2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CLDND2: view image
Paralogs for CLDND2 Gene
Variants for CLDND2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1140251 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.09;
68.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLDND2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CLDND2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLDND2 Gene
Disorders for CLDND2 Gene
Additional Disease Information for CLDND2
No disorders were found for CLDND2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDND2 Gene
Publications for CLDND2 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3
- Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3
ExternalLinks
Products for CLDND2 Gene
- Custom Antibody ServicesOriGene Antibodies for CLDND2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CLDND2
- Origene Custom Protein Services for CLDND2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLDND2
- Browse OriGene Inhibitory RNA Products For CLDND2
- OriGene qPCR primer pairs for CLDND2
- OriGene qPCR primer pairs and template standards for CLDND2
- OriGene CRISPR knockouts for CLDND2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CLDND2
- Sino Biological Human cDNA Clone for CLDND2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CLDND2
- Novus Biologicals proteins and lysates for CLDND2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for CLDND2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CLDND2 (AFLGC-CLDND2)
- VectorBuilder Custom and pre-made DNA vectors for CLDND2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CLDND2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CLDND2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CLDND2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CLDND2
- antibodies-online: Show 13 available CLDND2 Antibodies ranked by validation data
- antibodies-online: Search results for available CLDND2 related products ranked by validation data
- antibodies-online: Search results for available CLDND2 related products ranked by validation data
- Horizon Cell Lines for CLDND2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLDND2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLDND2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CLDND2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDND2
Sources for CLDND2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB