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CLDND2 Gene(Protein Coding)

Claudin Domain Containing 2

GCID:
GC19M051367
GIFtS:
35
Genes Participants
UDN Logo

Aliases for CLDND2 Gene

Aliases for CLDND2 Gene

  • Claudin Domain Containing 2 2 3 5

External Ids for CLDND2 Gene

Previous GeneCards Identifiers for CLDND2 Gene

  • GC19M056563
  • GC19M051870
  • GC19M048202

Summaries for CLDND2 Gene

GeneCards Summary for CLDND2 Gene

CLDND2 (Claudin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000269403.

Additional gene information for CLDND2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDND2 Gene

Genomics for CLDND2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CLDND2 Gene

Promoters and enhancers for CLDND2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I051360 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +4.3 4298 8.5 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A MEF2D ETFB CLDND2 ENSG00000268520 ZNF616 POLD1 ZNF766 ZNF836 ZNF841 ZNF577 ZNF175
GH19I051369 Enhancer 0.3 ENCODE 550.8 -0.4 -437 0.4 ZNF121 CLDND2 ENSG00000269403 NKG7
GH19I051338 Promoter/Enhancer 1.6 Ensembl ENCODE 12.2 +29.5 29456 2.8 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A YY1 POLR2B ZNF766 ZNF416 ENSG00000267905 ZNF841 ZNF577 POLD1 ZNF616 ZNF175 ZNF480 ZNF766 ZNF350 ZNF836
GH19I051406 Enhancer 1 Ensembl ENCODE 11.9 -39.0 -39026 2.9 ATF1 RAD21 ARID2 ZNF143 FOS ATF7 RCOR1 SMARCA5 REST MIER2 CLDND2 NKG7 ETFB SIGLEC8 VSIG10L RPL7P51 SIGLEC14 SIGLEC5 FPR3 SIGLEC10
GH19I051326 Enhancer 1 Ensembl ENCODE 11.4 +42.0 41998 1.9 HDAC1 ATF1 RB1 ARID4B ZBTB40 RAD21 ZNF48 ZNF335 POLR2B ATF7 ETFB CLDND2 NKG7 SIGLEC8 CEACAM18 SIGLEC14 SIGLEC5 RPL7P51 ENSG00000267905 GC19M051338
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLDND2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLDND2 gene promoter:

Genomic Locations for CLDND2 Gene

Genomic Locations for CLDND2 Gene
chr19:51,366,957-51,369,241
(GRCh38/hg38)
Size:
2,285 bases
Orientation:
Minus strand
chr19:51,870,352-51,872,257
(GRCh37/hg19)

Genomic View for CLDND2 Gene

Genes around CLDND2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDND2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDND2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CLDND2 Gene

Proteins for CLDND2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CLDND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHS1-CLDN2_HUMAN
    Recommended name:
    Claudin domain-containing protein 2
    Protein Accession:
    Q8NHS1

    Protein attributes for CLDND2 Gene

    Size:
    167 amino acids
    Molecular mass:
    17984 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDND2 Gene

Post-translational modifications for CLDND2 Gene

No Post-translational modifications

Other Protein References for CLDND2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDND2 Gene

Domains & Families for CLDND2 Gene

Gene Families for CLDND2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CLDND2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CLDND2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHS1

UniProtKB/Swiss-Prot:

CLDN2_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family.
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with CLDND2: view

Function for CLDND2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
genes like me logo Genes that share phenotypes with CLDND2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDND2 Gene

Localization for CLDND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDND2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDND2 gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLDND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDND2: view

Pathways & Interactions for CLDND2 Gene

SuperPathways for CLDND2 Gene

PathCards logo More details on SuperPathways for CLDND2
No Data Available

Interacting Proteins for CLDND2 Gene

Selected Interacting proteins: Q8NHS1-CLDN2_HUMAN for CLDND2 Gene via IID

Symbol External ID(s) Details
CREB3

Gene Ontology (GO) - Biological Process for CLDND2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLDND2 Gene

Drugs & Compounds for CLDND2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CLDND2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CLDND2 Gene

(7) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(320) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLDND2 Gene

Claudin domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDND2 Gene

No ASD Table

Relevant External Links for CLDND2 Gene

GeneLoc Exon Structure for
CLDND2
ECgene alternative splicing isoforms for
CLDND2

Expression for CLDND2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDND2 Gene

mRNA expression in normal human tissues for CLDND2 Gene
mRNA expression by BioGPS for CLDND2 GenemRNA expression by GTEx for CLDND2 Gene

mRNA differential expression in normal tissues according to GTEx for CLDND2 Gene

This gene is overexpressed in Testis (x9.4) and Whole Blood (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of CLDND2 Gene:

CLDND2

SOURCE GeneReport for Unigene cluster for CLDND2 Gene:

Hs.720536
genes like me logo Genes that share expression patterns with CLDND2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDND2 Gene

Orthologs for CLDND2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLDND2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CLDND2 33 34
  • 99.8 (n)
dog
(Canis familiaris)
 Mammalia CLDND2 33
  • 84.14 (n)
cow
(Bos Taurus)
 Mammalia CLDND2 33 34
  • 82.93 (n)
rat
(Rattus norvegicus)
 Mammalia Cldnd2 33
  • 76.65 (n)
mouse
(Mus musculus)
 Mammalia Cldnd2 33 16 34
  • 74.65 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CLDND2 34
  • 48 (a)
 OneToOne
Species where no ortholog for CLDND2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLDND2 Gene

ENSEMBL:
Gene Tree for CLDND2 (if available)
TreeFam:
Gene Tree for CLDND2 (if available)

Paralogs for CLDND2 Gene

Paralogs for CLDND2 Gene

genes like me logo Genes that share paralogs with CLDND2: view

Variants for CLDND2 Gene

Sequence variations from dbSNP and Humsavar for CLDND2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs202118581 benign, not specified 51,366,362(-) C/G/T downstream_transcript_variant
rs1002323217 -- 51,366,731(-) T/A downstream_transcript_variant
rs1002963012 -- 51,368,782(-) C/T 5_prime_UTR_variant, intron_variant
rs1004336890 -- 51,369,261(-) G/A upstream_transcript_variant
rs1004369396 -- 51,369,004(-) GGGGGG/GGGGGGG 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLDND2 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for CLDND2 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 68.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDND2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDND2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDND2 Gene

Disorders for CLDND2 Gene

Additional Disease Information for CLDND2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CLDND2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDND2 Gene

Publications for CLDND2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58
  4. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3

Products for CLDND2 Gene

Sources for CLDND2 Gene

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