CLDND2 Gene (Protein Coding)

Claudin Domain Containing 2

GC19M051367
GIFtS:
29
See more...

Aliases for CLDND2 Gene

Aliases for CLDND2 Gene

  • Claudin Domain Containing 2 2 3 5
  • Claudin Domain-Containing Protein 2 3 4
  • MGC33839 2
  • CLDND2 5

External Ids for CLDND2 Gene

Previous GeneCards Identifiers for CLDND2 Gene

  • GC19M056563
  • GC19M051870
  • GC19M048202

Summaries for CLDND2 Gene

GeneCards Summary for CLDND2 Gene

CLDND2 (Claudin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is LIM2.

Additional gene information for CLDND2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLDND2 Gene

Genomics for CLDND2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CLDND2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLDND2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLDND2

Top Transcription factor binding sites by QIAGEN in the CLDND2 gene promoter:
  • CP2
  • GATA-1
  • HSF2
  • NF-kappaB
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Pax-6

Genomic Locations for CLDND2 Gene

Latest Assembly
chr19:51,366,750-51,369,255
(GRCh38/hg38)
Size:
2,506 bases
Orientation:
Minus strand

Previous Assembly
chr19:51,870,352-51,872,257
(GRCh37/hg19 by Entrez Gene)
Size:
1,906 bases
Orientation:
Minus strand

chr19:51,870,352-51,872,257
(GRCh37/hg19 by Ensembl)
Size:
1,906 bases
Orientation:
Minus strand

Genomic View for CLDND2 Gene

Genes around CLDND2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDND2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDND2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CLDND2 Gene

Proteins for CLDND2 Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for CLDND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHS1-CLDN2_HUMAN
    Recommended name:
    Claudin domain-containing protein 2
    Protein Accession:
    Q8NHS1

    Protein attributes for CLDND2 Gene

    Size:
    167 amino acids
    Molecular mass:
    17984 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDND2 Gene

Post-translational modifications for CLDND2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDND2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDND2 Gene

Domains & Families for CLDND2 Gene

Gene Families for CLDND2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CLDND2 Gene

InterPro:
Blocks:
  • PMP-22/EMP/MP20 family
ProtoNet:

Suggested Antigen Peptide Sequences for CLDND2 Gene

GenScript: Design optimal peptide antigens:
  • Claudin domain-containing protein 2 (CLDN2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHS1

UniProtKB/Swiss-Prot:

CLDN2_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family.
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with CLDND2: view

Function for CLDND2 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for CLDND2 Gene

Gene Ontology (GO) - Molecular Function for CLDND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with CLDND2: view
genes like me logo Genes that share phenotypes with CLDND2: view

Animal Models for CLDND2 Gene

MGI Knock Outs for CLDND2:
  • Cldnd2 Cldnd2<tm1b(EUCOMM)Hmgu>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDND2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLDND2 Gene

Localization for CLDND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDND2 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDND2 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLDND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDND2: view

Pathways & Interactions for CLDND2 Gene

PathCards logo

SuperPathways for CLDND2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLDND2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLDND2 Gene

Drugs & Compounds for CLDND2 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for CLDND2 Gene

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  3. Inhibitory RNAs for research
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mRNA/cDNA for CLDND2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDND2

Alternative Splicing Database (ASD) splice patterns (SP) for CLDND2 Gene

No ASD Table

Relevant External Links for CLDND2 Gene

GeneLoc Exon Structure for
CLDND2

Expression for CLDND2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLDND2 Gene

mRNA expression in normal human tissues for CLDND2 Gene
mRNA expression by BioGPS for CLDND2 GenemRNA expression by GTEx for CLDND2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for CLDND2 Gene

This gene is overexpressed in Testis (x9.4) and Whole Blood (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLDND2

SOURCE GeneReport for Unigene cluster for CLDND2 Gene:

Hs.720536
genes like me logo Genes that share expression patterns with CLDND2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDND2 Gene

Orthologs for CLDND2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLDND2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CLDND2 30 31
  • 99.8 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CLDND2 30
  • 84.14 (n)
Cow
(Bos Taurus)
 Mammalia CLDND2 30 31
  • 82.93 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cldnd2 30
  • 76.65 (n)
Mouse
(Mus musculus)
 Mammalia Cldnd2 30 17 31
  • 74.65 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CLDND2 31
  • 48 (a)
 OneToOne
Species where no ortholog for CLDND2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CLDND2 Gene

ENSEMBL:
Gene Tree for CLDND2 (if available)
TreeFam:
Gene Tree for CLDND2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLDND2: view image

Paralogs for CLDND2 Gene

Paralogs for CLDND2 Gene

genes like me logo Genes that share paralogs with CLDND2: view

Variants for CLDND2 Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CLDND2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CLDND2 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for CLDND2 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 68.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDND2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDND2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLDND2 Gene

Disorders for CLDND2 Gene

Additional Disease Information for CLDND2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for CLDND2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDND2 Gene

Publications for CLDND2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3

ExternalLinks

View latest publications for CLDND2 gene in Mastermind

Products for CLDND2 Gene

  • Biorbyt antibodies for CLDND2

Sources for CLDND2 Gene