Aliases for CLDN7 Gene
Aliases for CLDN7 Gene
External Ids for CLDN7 Gene
- HGNC: 2049
- Entrez Gene: 1366
- Ensembl: ENSG00000181885
- OMIM: 609131
- UniProtKB: O95471
Previous HGNC Symbols for CLDN7 Gene
- CEPTRL2
- CPETRL2
Previous GeneCards Identifiers for CLDN7 Gene
- GC17M007585
- GC17M007893
- GC17M007106
- GC17M007364
- GC17M007104
- GC17M007103
- GC17M007163
- GC17M007054
Summaries for CLDN7 Gene
-
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
GeneCards Summary for CLDN7 Gene
CLDN7 (Claudin 7) is a Protein Coding gene. Diseases associated with CLDN7 include Ductal Carcinoma In Situ and Chromophobe Renal Cell Carcinoma. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Blood-Brain Barrier Pathway: Anatomy. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN1.
UniProtKB/Swiss-Prot for CLDN7 Gene
-
Plays a major role in tight junction-specific obliteration of the intercellular space.
Additional gene information for CLDN7 Gene
- Monarch Initiative
- Search for CLDN7 at DataMed
- Search for CLDN7 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN7 Gene
Genomics for CLDN7 Gene
GeneHancer (GH) Regulatory Elements for CLDN7 Gene
Promoters and enhancers for CLDN7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CLDN7 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CLDN7 gene promoter:
Regulatory Element Products
Genomic Locations for CLDN7 Gene
Genomic Locations for CLDN7 Gene
- chr17:7,259,903-7,263,983
- (GRCh38/hg38)
- Size:
- 4,081 bases
- Orientation:
- Minus strand
- chr17:7,163,222-7,167,302
- (GRCh37/hg19)
Genomic View for CLDN7 Gene
Genes around CLDN7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC
CLDN7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLDN7 Gene
Proteins for CLDN7 Gene
-
Protein details for CLDN7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95471-CLD7_HUMAN
- Recommended name:
- Claudin-7
- Protein Accession:
- O95471
- B2R9X7
- D3DTP0
- Q6IPN3
- Q7Z4Y7
- Q9BVN0
Protein attributes for CLDN7 Gene
- Size:
- 211 amino acids
- Molecular mass:
- 22418 Da
- Quaternary structure:
-
- Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM (PubMed:16054130). Does not interact with CD81 (PubMed:20375010).
- SequenceCaution:
-
- Sequence=AAP97219.1; Type=Frameshift; Positions=18, 23; Evidence={ECO:0000305};
Protein Expression for CLDN7 Gene
Post-translational modifications for CLDN7 Gene
- Phosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CLDN7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CLDN7
-
Abcam antibodies for CLDN7
- Invitrogen Antibodies for CLDN7
- antibodies-online: Search results for 123 available CLDN7 Antibodies ranked by validation data
- Compare Top CLDN7 Antibodies
-
Recommended
- 1 IHC Antibody (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 49 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 50 WB Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-human)
- 11 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 87 WB Antibodies (anti-human)
- GeneTex CLDN7 antibody for CLDN7
Protein Products
-
OriGene Purified Proteins for CLDN7
- Search Origene for MassSpec and Protein Over-expression Lysates for CLDN7
- Origene Custom Protein Services for CLDN7
- Search GeneTex for Proteins for CLDN7
-
Abcam proteins for CLDN7
Assay Products
No data available for DME Specific Peptides for CLDN7 Gene
Domains & Families for CLDN7 Gene
Gene Families for CLDN7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted membrane proteins
- Predicted secreted proteins
- Transporters
Protein Domains for CLDN7 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CLDN7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95471- Family:
-
- Belongs to the claudin family.
Function for CLDN7 Gene
Molecular function for CLDN7 Gene
- GENATLAS Biochemistry:
- claudin 7,clostridium perfringens enterotoxin receptor-like 2,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,primarly expressed in lung and kidney
- UniProtKB/Swiss-Prot Function:
- Plays a major role in tight junction-specific obliteration of the intercellular space.
- UniProtKB/Swiss-Prot Induction:
- By androgens.
Phenotypes From GWAS Catalog for CLDN7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16054130 |
| GO:0042802 | identical protein binding | ISS | -- |
| GO:0050839 | cell adhesion molecule binding | IEA | -- |
Phenotypes for CLDN7 Gene
- MGI mutant phenotypes for CLDN7:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CLDN7:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
Animal Models for CLDN7 Gene
- MGI Knock Outs for CLDN7:
-
- Cldn7 tm1Yche
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CLDN7
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CLDN7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CLDN7 gene
- Search ViGene Biosciences for CLDN7
CRISPR Products
-
OriGene CRISPR knockouts for CLDN7
- genomics-online: gRNA clones - Search results for available CLDN7 gene related products
- Applied Biological Materials CRISPR for CLDN7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLDN7
- GenScript: Design CRISPR guide RNA sequences for CLDN7
miRNA for CLDN7 Gene
- miRTarBase miRNAs that target CLDN7
-
- hsa-mir-335-5p (MIRT017878)
- hsa-mir-484 (MIRT042085)
- hsa-mir-140-3p (MIRT737569)
- hsa-mir-3620-3p (MIRT741736)
- hsa-mir-3670 (MIRT742088)
- hsa-mir-3929 (MIRT743064)
- hsa-mir-4419b (MIRT744231)
- hsa-mir-4438 (MIRT744501)
- hsa-mir-4478 (MIRT745070)
- hsa-mir-4663 (MIRT746711)
- hsa-mir-6752-3p (MIRT754608)
- hsa-mir-6854-5p (MIRT757669)
miRNA Products
- Search ViGene Biosciences for CLDN7
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for CLDN7
- Browse OriGene Inhibitory RNA Products For CLDN7
- genomics-online: shRNA clones - Search results for available CLDN7 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CLDN7 gene
Clone Products
-
OriGene ORF clones in human for CLDN7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CLDN7
- VectorBuilder custom plasmid, inducible vectors for CLDN7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CLDN7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CLDN7
- genomics-online: cdna clones - Search results for available CLDN7 gene related products
- orf clones - Search results for available CLDN7 gene related products
- Applied Biological Materials Clones for CLDN7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CLDN7 (Claudin-7)
Cell Line Products
-
Horizon Cell Lines for CLDN7
-
ViGene Biosciences adenoviral particle packaged cDNA for CLDN7 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CLDN7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CLDN7 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLDN7 Gene
Localization for CLDN7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLDN7 Gene
- Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cell junction, tight junction. Note=Co-localizes with EPCAM at the basolateral cell membrane and tight junction. {ECO:0000269 PubMed:16054130}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 2 |
| extracellular | 1 |
| nucleus | 1 |
- Cell Junctions (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IDA,IEA | 20375010 |
| GO:0005923 | bicellular tight junction | ISS,IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016323 | basolateral plasma membrane | IEA | -- |
Pathways & Interactions for CLDN7 Gene
Pathways by source for CLDN7 Gene
4 Reactome pathways for CLDN7 Gene
4 KEGG pathways for CLDN7 Gene
1 GeneGo (Thomson Reuters) pathway for CLDN7 Gene
6 R&D Systems pathways for CLDN7 Gene
- Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways
3 Qiagen pathways for CLDN7 Gene
Interacting Proteins for CLDN7 Gene
Selected Interacting proteins:
ENSP00000353475
O95471-CLD7_HUMAN
for CLDN7 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007162 | negative regulation of cell adhesion | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
| GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules | ISS | -- |
| GO:0032463 | negative regulation of protein homooligomerization | IEA | -- |
| GO:0043066 | negative regulation of apoptotic process | IEA | -- |
No data available for SIGNOR curated interactions for CLDN7 Gene
Transcripts for CLDN7 Gene
mRNA/cDNA for CLDN7 Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (672) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CLDN7
- genomics-online: gRNA clones - Search results for available CLDN7 gene related products
- Applied Biological Materials CRISPR for CLDN7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLDN7
- GenScript: Design CRISPR guide RNA sequences for CLDN7
miRNA Products
- Search ViGene Biosciences for CLDN7
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for CLDN7
- Browse OriGene Inhibitory RNA Products For CLDN7
- genomics-online: shRNA clones - Search results for available CLDN7 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CLDN7 gene
Clone Products
-
OriGene ORF clones in human for CLDN7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CLDN7
- VectorBuilder custom plasmid, inducible vectors for CLDN7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CLDN7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CLDN7
- genomics-online: cdna clones - Search results for available CLDN7 gene related products
- orf clones - Search results for available CLDN7 gene related products
- Applied Biological Materials Clones for CLDN7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CLDN7 (Claudin-7)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||
| SP5: |
Expression for CLDN7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Presumptive Podocytes Podocyte Layer
- Ureteric Bud Tip Cells Ureteric Bud
- Renal Collecting Duct System
- Ureteric Bud
- Gut Tube (Gastrointestinal Tract)
-
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
- Oviduct
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
- Thyroid (Endocrine System)
- Lung (Respiratory System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Inner Cell Mass (Early Embryonic Tissues)
- NULL (Uncategorized)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CLDN7 Gene
This gene is overexpressed in Colon - Transverse (x13.2), Esophagus - Mucosa (x8.7), Small Intestine - Terminal Ileum (x5.1), and Minor Salivary Gland (x4.9).
This gene is overexpressed in Oral epithelium (14.8), Salivary gland (11.2), Stomach (7.1), Islet of Langerhans (6.4), and Tonsil (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLDN7 Gene
NURSA nuclear receptor signaling pathways regulating expression of CLDN7 Gene:
CLDN7SOURCE GeneReport for Unigene cluster for CLDN7 Gene:
Hs.513915mRNA Expression by UniProt/SwissProt for CLDN7 Gene:
O95471-CLD7_HUMAN
Tissue specificity:
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Evidence on tissue expression from TISSUES for CLDN7 Gene
- Intestine(4.7)
- Lung(2.7)
- Kidney(2.4)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs for CLDN7
-
OriGene qPCR primer pairs and template standards for CLDN7
- genomics-online: primer clones - Search results for available CLDN7 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN7 Gene
Orthologs for CLDN7 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CLDN7 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CLDN7 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CLDN7 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cldn7 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cldn7 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CLDN7 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | cldn7b 33 34 |
|
||
| cldn7a 34 |
|
OneToMany |
- Species where no ortholog for CLDN7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CLDN7 Gene
Paralogs for CLDN7 Gene
(19) SIMAP similar genes for CLDN7 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for CLDN7 Gene
Variants for CLDN7 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000420016 | -- | 7,262,465(-) | C/T | 5_prime_UTR_variant, intron_variant | |
| rs1001008709 | -- | 7,260,316(-) | C/T | 3_prime_UTR_variant | |
| rs1001778472 | -- | 7,264,559(-) | GGG/GGGG | upstream_transcript_variant | |
| rs1002355560 | -- | 7,263,725(-) | C/G | upstream_transcript_variant | |
| rs1002503196 | -- | 7,263,072(-) | T/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv885e212 | CNV | loss | 25503493 |
| esv2422288 | CNV | deletion | 17116639 |
| esv2665200 | CNV | deletion | 23128226 |
| esv3639861 | CNV | loss | 21293372 |
| nsv1963 | CNV | deletion | 18451855 |
| nsv457659 | CNV | loss | 19166990 |
| nsv480494 | CNV | novel sequence insertion | 20440878 |
| nsv574322 | CNV | loss | 21841781 |
| nsv952118 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.05;
21.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLDN7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CLDN7
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN7 Gene
Disorders for CLDN7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ductal carcinoma in situ |
|
|
| chromophobe renal cell carcinoma |
|
|
| prostate transitional cell carcinoma |
|
|
| gastric adenocarcinoma |
|
|
| breast cancer |
|
Search CLDN7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CLDN7
No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN7 Gene
Publications for CLDN7 Gene
- The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. (PMID: 16054130) Ladwein M … Zöller M (Experimental cell research 2005) 3 4 22 58
- Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. (PMID: 12673207) Kominsky SL … Sukumar S (Oncogene 2003) 3 4 22 58
- Regulation of the expression of the prostate-specific antigen by claudin-7. (PMID: 14502431) Zheng JY … Pang S (The Journal of membrane biology 2003) 3 4 22 58
- Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas. (PMID: 19960275) Rendón-Huerta E … Montaño LF (Journal of gastrointestinal cancer 2010) 3 22 58
- Claudin association with CD81 defines hepatitis C virus entry. (PMID: 20375010) Harris HJ … McKeating JA (The Journal of biological chemistry 2010) 3 4 58
Products for CLDN7 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for CLDN7
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- OriGene qPCR primer pairs and template standards for CLDN7
- OriGene qPCR primer pairs for CLDN7
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- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
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- Novus Biologicals Antibodies for CLDN7
- Novus Biologicals lysates and proteins for CLDN7
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for CLDN7
- Abcam proteins for CLDN7
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- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for CLDN7
- VectorBuilder custom plasmid, inducible vectors for CLDN7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CLDN7
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CLDN7
- antibodies-online: Search results for 123 available CLDN7 Antibodies ranked by validation data
- Compare Top CLDN7 Antibodies
- Recommended
- 87 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 11 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 50 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 49 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Search results for 23 available CLDN7 Elisa Kits ranked by validation data
- Compare Top CLDN7 Elisa Kits
- antibodies-online: Search results for 4 available CLDN7 Proteins ranked by validation data
- Compare Top CLDN7 Proteins
- GeneTex CLDN7 antibody for CLDN7
- Search GeneTex for Proteins for CLDN7
- ViGene Biosciences adenoviral particle packaged cDNA for CLDN7 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CLDN7 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CLDN7 gene
- Search ViGene Biosciences for CLDN7
- Horizon Cell Lines for CLDN7
- genomics-online: cdna clones - Search results for available CLDN7 gene related products
- orf clones - Search results for available CLDN7 gene related products
- genomics-online: gRNA clones - Search results for available CLDN7 gene related products
- genomics-online: primer clones - Search results for available CLDN7 gene related products
- genomics-online: shRNA clones - Search results for available CLDN7 gene related products
Sources for CLDN7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems