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This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofaci... See more...
Aliases for CLDN5 Gene
Aliases for CLDN5 Gene
External Ids for CLDN5 Gene
- HGNC: 2047
- Entrez Gene: 7122
- Ensembl: ENSG00000184113
- OMIM: 602101
- UniProtKB: O00501
Previous HGNC Symbols for CLDN5 Gene
- AWAL
- TMVCF
Previous GeneCards Identifiers for CLDN5 Gene
- GC22M016450
- GC22M017885
- GC22M019510
- GC22M003131
Summaries for CLDN5 Gene
-
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]
GeneCards Summary for CLDN5 Gene
CLDN5 (Claudin 5) is a Protein Coding gene. Diseases associated with CLDN5 include Velocardiofacial Syndrome and Brain Edema. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Pathogenic Escherichia coli infection. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN3.
UniProtKB/Swiss-Prot Summary for CLDN5 Gene
-
Plays a major role in tight junction-specific obliteration of the intercellular space.
Additional gene information for CLDN5 Gene
- HGNC(2047)
- Entrez Gene(7122)
- Ensembl(ENSG00000184113)
- OMIM(602101)
- UniProtKB(O00501)
- Open Targets Platform(ENSG00000184113)
- Search for CLDN5 at DataMed
- Search for CLDN5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLDN5 Gene
Genomics for CLDN5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CLDN5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CLDN5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLDN5
- Top Transcription factor binding sites by QIAGEN in the CLDN5 gene promoter:
-
- AP-2alpha
- ATF-2
- c-Myb
- CRE-BP1
- GATA-1
- MyoD
- PPAR-alpha
- Spz1
- TBP
- Zic3
Genomic Locations for CLDN5 Gene
Genomic Locations for CLDN5 Gene
- chr22:19,523,024-19,527,545
- (GRCh38/hg38)
- Size:
- 4,522 bases
- Orientation:
- Minus strand
- chr22:19,510,547-19,515,068
- (GRCh37/hg19)
- Size:
- 4,522 bases
- Orientation:
- Minus strand
Genomic View for CLDN5 Gene
Genes around CLDN5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by HGNC
- 22q11.21 by Entrez Gene
- 22q11.21 by Ensembl
CLDN5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLDN5 Gene
Proteins for CLDN5 Gene
-
Protein details for CLDN5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00501-CLD5_HUMAN
- Recommended name:
- Claudin-5
- Protein Accession:
- O00501
- B3KS11
- Q53XW2
- Q8WUW3
Protein attributes for CLDN5 Gene
- Size:
- 218 amino acids
- Molecular mass:
- 23147 Da
- Quaternary structure:
-
- Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ (By similarity).
Protein Expression for CLDN5 Gene
Post-translational modifications for CLDN5 Gene
Other Protein References for CLDN5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CLDN5 / Claudin 5 Monoclonal Antibody and CLDN5 / Claudin 5 Antibody
- GeneTex Anti-Claudin 5 antibody
-
Custom Antibody ServicesOriGene Antibodies for CLDN5
- Novus Biologicals Antibodies for CLDN5
-
Abcam antibodies for CLDN5
- Invitrogen Antibodies for CLDN5 (AFLGC-CLDN5)
- antibodies-online: Show 26 available CLDN5 Antibodies ranked by validation data
- Compare Top CLDN5 Antibodies
-
Recommended
- 47 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 41 WB Antibodies (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 36 WB Antibodies (anti-rat)
- 8 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for CLDN5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CLDN5
Protein Products
-
OriGene Purified Proteins for CLDN5
- Search Origene for MassSpec and Protein Over-expression Lysates for CLDN5
- Origene Custom Protein Services for CLDN5
-
Abcam proteins for CLDN5
Assay Products
- G Biosciences Immunotag™ Human CLDN5 (Claudin 5) ELISA
- Novus Biologicals ELISA Kits for CLDN5
- antibodies-online: Show 47 available CLDN5 Elisa Kits ranked by validation data
- Compare Top CLDN5 Elisa Kits
-
Quality Products:
- ABIN831363
- ABIN420914
- ABIN1569031
- ABIN5520334
- ABIN4993381
- ABIN1381027
- ABIN5652989
- ABIN2543006
- ABIN1742872
- ABIN6203382
- ABIN831364
- ABIN428291
- ABIN2851062
- ABIN2543007
- ABIN1745312
- ABIN5652990
- ABIN6203383
- ABIN2683828
- ABIN2043163
- ABIN831365
- ABIN435187
- ABIN1569032
- ABIN5520337
- ABIN4993382
- ABIN2543008
- ABIN1744093
- ABIN5652991
- ABIN6203384
-
Boster Bio ELISA Kits for CLDN5
-
Signalway ELISA kits for CLDN5
No data available for DME Specific Peptides for CLDN5 Gene
Domains & Families for CLDN5 Gene
Gene Families for CLDN5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for CLDN5 Gene
- InterPro:
- Blocks:
-
- Claudin family signature
- Claudin-5 signature
- ProtoNet:
Suggested Antigen Peptide Sequences for CLDN5 Gene
- GenScript: Design optimal peptide antigens:
-
- Transmembrane protein deleted in VCFS (CLD5_HUMAN)
- Claudin 5 (Transmembrane protein deleted in velocardiofacial syndrome), isoform CRA_a (D3DX19_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O00501- Family:
-
- Belongs to the claudin family.
Function for CLDN5 Gene
Molecular function for CLDN5 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a major role in tight junction-specific obliteration of the intercellular space.
- GENATLAS Biochemistry:
- claudin 5,clostridium perfringens enterotoxin receptor-like,transmembrane protein,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,expressed in lung,heart,skeletal muscle,homolog to rat ventral prostate protein,deleted in velocardiofacial syndrome,DiGeorge region
Phenotypes From GWAS Catalog for CLDN5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25323998 |
| GO:0042802 | identical protein binding | ISS | -- |
Phenotypes for CLDN5 Gene
- MGI mutant phenotypes for CLDN5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CLDN5:
Animal Models for CLDN5 Gene
- MGI Knock Outs for CLDN5:
-
- Cldn5 Cldn5<tm1Sts>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLDN5 - Select products 50% OFF >
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OriGene CRISPR knockouts for CLDN5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLDN5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLDN5
miRNA for CLDN5 Gene
- miRTarBase miRNAs that target CLDN5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLDN5
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Clone Products
- Applied Biological Materials (abm): Clones for CLDN5 - Select products 50% OFF >
- * CLDN5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202442
- MR202442
- MR202442L1
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- MR202442L4
- RC207122
- RC207122L1
- RC207122L2
- RC207122L3
- RC207122L4
- RC225423
- RC225423L1
- RC225423L2
- RC225423L3
- RC225423L4
- RG207122
- RG225423
- RR202322
- RR202322L3
- RR202322L4
- MR202442L1V
- MR202442L2V
- MR202442L3V
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- RC207122L1V
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- RC225423L1V
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- RC225423L3V
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- RR202322L3V
- RR202322L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CLDN5
- Addgene plasmids for CLDN5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLDN5
Cell Line Products
-
Horizon Cell Lines for CLDN5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLDN5 Gene
Localization for CLDN5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLDN5 Gene
- Cell junction, tight junction. Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA,IDA | 25978380 |
| GO:0005911 | cell-cell junction | IMP | 25753039 |
| GO:0005923 | bicellular tight junction | IEA,ISS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,TAS | 9192844 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN5 Gene
Pathways & Interactions for CLDN5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling | ||
| 2 | Cell junction organization | ||
| 3 | Blood-Brain Barrier: Anatomy | ||
| 4 | Sertoli-Sertoli Cell Junction Dynamics |
Sertoli-Sertoli Cell Junction Dynamics
.38
|
Epithelial Tight Junctions
.36
|
| 5 | Cell adhesion molecules (CAMs) | ||
Pathways by source for CLDN5 Gene
1 BioSystems pathway for CLDN5 Gene
4 Reactome pathways for CLDN5 Gene
5 KEGG pathways for CLDN5 Gene
2 GeneGo (Thomson Reuters) pathways for CLDN5 Gene
- Cell adhesion Tight junctions
- Cell adhesion_Endothelial cell contacts by junctional mechanisms
6 R&D Systems pathways for CLDN5 Gene
- Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling
- Blood-Brain Barrier and Immune Cell Transmigration: Overview
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling
- Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling
3 Qiagen pathways for CLDN5 Gene
- Epithelial Tight Junctions
- Sertoli-Sertoli Cell Junction Dynamics
- Transendothelial Migration of Leukocytes
Interacting Proteins for CLDN5 Gene
Selected Interacting proteins:
O00501-CLD5_HUMAN
ENSP00000385477
for CLDN5 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CLDN5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003151 | outflow tract morphogenesis | TAS | 9192844 |
| GO:0007043 | cell-cell junction assembly | IMP | 23288152 |
| GO:0007155 | cell adhesion | IBA | 21873635 |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 21168935 |
| GO:0007612 | learning | TAS | 9192844 |
No data available for SIGNOR curated interactions for CLDN5 Gene
Transcripts for CLDN5 Gene
mRNA/cDNA for CLDN5 Gene
- 4 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000406028 2548 nts (view in UCSC)
- ENST00000618236 1374 nts (view in UCSC)
- ENST00000403084 2357 nts (view in UCSC)
- ENST00000413119 1760 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLDN5 - Select products 50% OFF >
- * CLDN5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CLDN5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLDN5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLDN5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLDN5
- Browse OriGene Inhibitory RNA Products For CLDN5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN5
Clone Products
- Applied Biological Materials (abm): Clones for CLDN5 - Select products 50% OFF >
- * CLDN5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202442
- MR202442
- MR202442L1
- MR202442L2
- MR202442L3
- MR202442L4
- RC207122
- RC207122L1
- RC207122L2
- RC207122L3
- RC207122L4
- RC225423
- RC225423L1
- RC225423L2
- RC225423L3
- RC225423L4
- RG207122
- RG225423
- RR202322
- RR202322L3
- RR202322L4
- MR202442L1V
- MR202442L2V
- MR202442L3V
- MR202442L4V
- RC207122L1V
- RC207122L2V
- RC207122L3V
- RC207122L4V
- RC225423L1V
- RC225423L2V
- RC225423L3V
- RC225423L4V
- RR202322L3V
- RR202322L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CLDN5
- Addgene plasmids for CLDN5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLDN5
Relevant External Links for CLDN5 Gene
- GeneLoc Exon Structure for
- CLDN5
Expression for CLDN5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Atrioventricular Canal Cells Atrioventricular Canal
- Heart Tube
- Brain (Nervous System)
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Endothelial cells(Lippmann ES et. al. 2012)
- Brain microvascular endothelial cells (Lippmann ES et. al. 2012)
- Kidney (Urinary System)
- Adipose (Muscoskeletal System)
- Gonad
- NULL (Uncategorized)
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
-
Tooth
- Dental Mesenchymal Cells Branchial Arch 1
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
- Intermediate Mesoderm (Gastrulation Derivatives)
- Lung (Respiratory System)
- Germ Cells (Reproductive System)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Testis (Reproductive System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for CLDN5 Gene
This gene is overexpressed in Adipose - Subcutaneous (x4.1).
This gene is overexpressed in Peripheral blood mononuclear cells (21.6), Platelet (15.6), and Lung (15.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLDN5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLDN5
SOURCE GeneReport for Unigene cluster for CLDN5 Gene:
Hs.505337Evidence on tissue expression from TISSUES for CLDN5 Gene
- Nervous system(4.9)
- Lung(4.7)
- Heart(3.6)
- Blood(3.1)
- Muscle(2.9)
- Intestine(2.8)
- Eye(2.7)
- Kidney(2.6)
- Skin(2.6)
- Stomach(2.2)
- Liver(2.2)
- Spleen(2.2)
- Lymph node(2.1)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for CLDN5
-
OriGene qPCR primer pairs and template standards for CLDN5
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN5 Gene
Orthologs for CLDN5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CLDN5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CLDN5 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | CLDN5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cldn5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cldn5 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CLDN5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CLDN5 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cldn5 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cldn5a 30 31 |
|
OneToMany | |
| cldn5b 31 |
|
OneToMany | |||
| cldnk 31 |
|
OneToMany | |||
| FP102191.1 31 |
|
OneToMany |
- Species where no ortholog for CLDN5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CLDN5 Gene
- ENSEMBL:
- Gene Tree for CLDN5 (if available)
- TreeFam:
- Gene Tree for CLDN5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CLDN5: view image
Paralogs for CLDN5 Gene
Paralogs for CLDN5 Gene
(18) SIMAP similar genes for CLDN5 Gene using alignment to 2 proteins:
- CLD5_HUMAN
- D3DX19_HUMAN
Variants for CLDN5 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4478n100 | CNV | loss | 25217958 |
| esv2751940 | CNV | gain | 17911159 |
| esv3575418 | CNV | gain | 25503493 |
| esv3893434 | CNV | gain | 25118596 |
| nsv588216 | CNV | gain | 21841781 |
| nsv834127 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.81;
83.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLDN5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CLDN5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLDN5 Gene
Disorders for CLDN5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| velocardiofacial syndrome |
|
|
| brain edema |
|
|
| lymphocytic colitis |
|
|
| meningoencephalitis |
|
|
| demyelinating polyneuropathy |
|
|
Search CLDN5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CLDN5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN5 Gene
Publications for CLDN5 Gene
- Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. (PMID: 9192844) Sirotkin H … Kucherlapati R (Genomics 1997) 2 3 4 23
- Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma. (PMID: 20044634) Turunen M … Santala M (Anticancer research 2009) 3 23
- Expression pattern of claudins 5 and 7 distinguishes solid-pseudopapillary from pancreatoblastoma, acinar cell and endocrine tumors of the pancreas. (PMID: 19194274) Comper F … Scarpa A (The American journal of surgical pathology 2009) 3 23
- Diagnostic utility of expression of claudins in non-small cell lung cancer: different expression profiles in squamous cell carcinomas and adenocarcinomas. (PMID: 19231096) Jung JH … Lee KY (Pathology, research and practice 2009) 3 23
- Structure and function of extracellular claudin domains. (PMID: 19538285) Krause G … Müller SL (Annals of the New York Academy of Sciences 2009) 3 23
ExternalLinks
Products for CLDN5 Gene
- Custom Antibody ServicesOriGene Antibodies for CLDN5
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CLDN5
- Search Origene for MassSpec and Protein Over-expression Lysates for CLDN5
- Origene Custom Protein Services for CLDN5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLDN5
- Browse OriGene Inhibitory RNA Products For CLDN5
- OriGene qPCR primer pairs for CLDN5
- OriGene qPCR primer pairs and template standards for CLDN5
- OriGene CRISPR knockouts for CLDN5
- MG202442
- MR202442
- MR202442L1
- MR202442L2
- MR202442L3
- MR202442L4
- RC207122
- RC207122L1
- RC207122L2
- RC207122L3
- RC207122L4
- RC225423
- RC225423L1
- RC225423L2
- RC225423L3
- RC225423L4
- RG207122
- RG225423
- RR202322
- RR202322L3
- RR202322L4
- MR202442L1V
- MR202442L2V
- MR202442L3V
- MR202442L4V
- RC207122L1V
- RC207122L2V
- RC207122L3V
- RC207122L4V
- RC225423L1V
- RC225423L2V
- RC225423L3V
- RC225423L4V
- RR202322L3V
- RR202322L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CLDN5
- Sino Biological Human cDNA Clone for CLDN5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CLDN5
- Novus Biologicals proteins and lysates for CLDN5
- Novus Biologicals ELISA Kits for CLDN5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CLDN5
- Abcam proteins for CLDN5
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CLDN5 (AFLGC-CLDN5)
- VectorBuilder Custom and pre-made DNA vectors for CLDN5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CLDN5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CLDN5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CLDN5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CLDN5
- Addgene plasmids for CLDN5
- antibodies-online: Show 26 available CLDN5 Antibodies ranked by validation data
- Compare Top CLDN5 Antibodies
- Recommended
- 47 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 41 WB Antibodies (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 36 WB Antibodies (anti-rat)
- 8 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Show 47 available CLDN5 Elisa Kits ranked by validation data
- Compare Top CLDN5 Elisa Kits
- Quality Products:
- ABIN831363
- ABIN420914
- ABIN1569031
- ABIN5520334
- ABIN4993381
- ABIN1381027
- ABIN5652989
- ABIN2543006
- ABIN1742872
- ABIN6203382
- ABIN831364
- ABIN428291
- ABIN2851062
- ABIN2543007
- ABIN1745312
- ABIN5652990
- ABIN6203383
- ABIN2683828
- ABIN2043163
- ABIN831365
- ABIN435187
- ABIN1569032
- ABIN5520337
- ABIN4993382
- ABIN2543008
- ABIN1744093
- ABIN5652991
- ABIN6203384
- antibodies-online: Show 8 available CLDN5 Proteins ranked by validation data
- Compare Top CLDN5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CLDN5
- Search Santa Cruz Biotechnology (SCBT) for CLDN5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CLDN5
- Horizon Cell Lines for CLDN5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLDN5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLDN5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CLDN5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN5
- Boster Bio Antibodies for CLDN5
- Boster Bio ELISA Kits for CLDN5
- Signalway ELISA kits for CLDN5
Sources for CLDN5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB