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Aliases for CLDN34 Gene

Aliases for CLDN34 Gene

  • Claudin 34 2 3 5
  • Claudin-34 3

External Ids for CLDN34 Gene

Summaries for CLDN34 Gene

GeneCards Summary for CLDN34 Gene

CLDN34 (Claudin 34) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CLDN34 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Additional gene information for CLDN34 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN34 Gene

Genomics for CLDN34 Gene

GeneHancer (GH) Regulatory Elements for CLDN34 Gene

Promoters and enhancers for CLDN34 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ009910 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 13.7 -49.0 -49030 2.9 ZNF316 JUN ZSCAN4 SIN3A MAFK SHROOM2 CLDN34 ENSG00000206844 GC0XM009878
GH0XJ010118 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.1 +159.3 159328 4.5 HDGF PKNOX1 FOXA2 CLOCK ARNT ARID4B SIN3A ZNF2 IRF4 YY1 CLCN4 CLDN34 ENSG00000202469 WWC3
GH0XJ010003 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 0.3 +42.7 42661 1.4 PKNOX1 FOXA2 SMAD1 SIN3A ATF7 FOS RUNX3 DEK JUNB REST WWC3 CLDN34
GH0XJ009980 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.3 +20.1 20097 2.2 HDGF SOX5 SOX13 PKNOX1 ZNF687 TFE3 NR2F1 ELF1 ZNF217 IKZF1 WWC3 CLDN34
GH0XJ009942 Enhancer 0.8 ENCODE 0.4 -18.9 -18916 0.7 PKNOX1 SMAD1 STAT5A BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 SHROOM2 CLDN34 GC0XM009878 ENSG00000206844
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLDN34 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CLDN34 Gene

Genomic Locations for CLDN34 Gene
7,015 bases
Plus strand

Genomic View for CLDN34 Gene

Genes around CLDN34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN34 Gene

Proteins for CLDN34 Gene

  • Protein details for CLDN34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for CLDN34 Gene

    214 amino acids
    Molecular mass:
    24226 Da
    Quaternary structure:
    • Can form homo- and heteropolymers with other CLDN.

neXtProt entry for CLDN34 Gene

Post-translational modifications for CLDN34 Gene

No Post-translational modifications

Other Protein References for CLDN34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN34 Gene

Domains & Families for CLDN34 Gene

Gene Families for CLDN34 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLDN34 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the claudin family.
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN34: view

No data available for Suggested Antigen Peptide Sequences for CLDN34 Gene

Function for CLDN34 Gene

Molecular function for CLDN34 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with CLDN34: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN34

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN34 Gene

Localization for CLDN34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN34 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN34 gene
Compartment Confidence
plasma membrane 5
lysosome 1

Gene Ontology (GO) - Cellular Components for CLDN34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN34: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN34 Gene

Pathways & Interactions for CLDN34 Gene

SuperPathways for CLDN34 Gene

No Data Available

Interacting Proteins for CLDN34 Gene

Gene Ontology (GO) - Biological Process for CLDN34 Gene


No data available for Pathways by source and SIGNOR curated interactions for CLDN34 Gene

Drugs & Compounds for CLDN34 Gene

No Compound Related Data Available

Transcripts for CLDN34 Gene

mRNA/cDNA for CLDN34 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN34

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN34 Gene

No ASD Table

Relevant External Links for CLDN34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN34 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLDN34 Gene:

genes like me logo Genes that share expression patterns with CLDN34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN34 Gene

Orthologs for CLDN34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN34 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC100686536 33
  • 71.05 (n)
-- 34
  • 43 (a)
(Bos Taurus)
Mammalia LOC100847650 33
  • 70.21 (n)
-- 34
  • 46 (a)
(Rattus norvegicus)
Mammalia LOC680489 33
  • 62.24 (n)
(Mus musculus)
Mammalia Gm6927 33
  • 60.51 (n)
Gm7157 34
  • 39 (a)
4930412D23Rik 34
  • 38 (a)
Gm4937 34
  • 36 (a)
4930428D18Rik 34
  • 36 (a)
Gm16390 34
  • 36 (a)
1700042B14Rik 34
  • 36 (a)
4930468A15Rik 34
  • 34 (a)
Gm6604 34
  • 30 (a)
Gm5167 34
  • 29 (a)
3110007F17Rik 34
  • 29 (a)
Cldn34-ps 16
(Monodelphis domestica)
Mammalia -- 34
  • 39 (a)
(Gallus gallus)
Aves LOC101749507 33
  • 57.65 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
-- 34
  • 20 (a)
-- 34
  • 19 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732192 33
  • 51.44 (n)
(Danio rerio)
Actinopterygii LOC101882682 33
  • 48.4 (n)
CABZ01080074.1 34
  • 33 (a)
CABZ01007930.1 34
  • 23 (a)
Species where no ortholog for CLDN34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN34 Gene

Gene Tree for CLDN34 (if available)
Gene Tree for CLDN34 (if available)
Evolutionary constrained regions (ECRs) for CLDN34: view image

Paralogs for CLDN34 Gene

No data available for Paralogs for CLDN34 Gene

Variants for CLDN34 Gene

Sequence variations from dbSNP and Humsavar for CLDN34 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000190810 -- 9,962,495(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000647472 -- 9,961,989(+) A/G genic_upstream_transcript_variant, intron_variant
rs1001254145 -- 9,963,762(+) A/G genic_upstream_transcript_variant, intron_variant
rs1001418516 -- 9,968,398(+) A/C downstream_transcript_variant
rs1002662249 -- 9,965,415(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Additional Variant Information for CLDN34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CLDN34 Gene

Disorders for CLDN34 Gene

Additional Disease Information for CLDN34

No disorders were found for CLDN34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN34 Gene

Publications for CLDN34 Gene

  1. Phylogenetic revision of the claudin gene family. (PMID: 23726886) Baltzegar DA … Borski RJ (Marine genomics 2013) 2 3 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58

Products for CLDN34 Gene

Sources for CLDN34 Gene

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