Aliases for CLDN3 Gene
External Ids for CLDN3 Gene
Previous HGNC Symbols for CLDN3 Gene
Previous GeneCards Identifiers for CLDN3 Gene
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLDN3 Gene
CLDN3 (Claudin 3) is a Protein Coding gene. Diseases associated with CLDN3 include Papillary Carcinoma and Williams-Beuren Syndrome. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview and Cell junction organization. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN4.
UniProtKB/Swiss-Prot Summary for CLDN3 Gene
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.