This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal t... See more...

Aliases for CLDN25 Gene

Aliases for CLDN25 Gene

  • Claudin 25 2 3 5
  • Putative Claudin-25 3 4
  • CLDN25 5

External Ids for CLDN25 Gene

Previous GeneCards Identifiers for CLDN25 Gene

  • GC11P113158
  • GC11P113650
  • GC11P109579

Summaries for CLDN25 Gene

Entrez Gene Summary for CLDN25 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN25 Gene

CLDN25 (Claudin 25) is a Protein Coding gene. Diseases associated with CLDN25 include Craniofacial-Deafness-Hand Syndrome. Among its related pathways are Cell adhesion molecules and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is CLDN22.

UniProtKB/Swiss-Prot Summary for CLDN25 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLDN25 Gene

Genomics for CLDN25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CLDN25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J113777 Enhancer 0.9 Ensembl ENCODE 250.7 -1.6 -1572 1.5 CEBPA THAP11 FOXA2 SMAD4 MAFF SAP130 ZNF341 RXRA ZBTB33 ZNF316 CLDN25 ATF4P4 DRD2 ZW10 lnc-ZW10-1
GH11J114031 Enhancer 0.6 FANTOM5 Ensembl 10.8 +252.8 252754 2.2 FOXA2 FOXA1 PKNOX1 HLF EZH2 NNMT CLDN25 USP28 lnc-USP28-2 FJ601666-017 ZBTB16 HSALNG0087286 HTR3A
GH11J113505 Enhancer 0.9 FANTOM5 Ensembl ENCODE 5.5 -273.4 -273431 2.4 CEBPA SOX5 CEBPG GATA2 CEBPB SOX13 NFIL3 HLF HSALNG0087252 HSALNG0087253 DRD2 CLDN25 lnc-ANKK1-4 TMPRSS5
GH11J113767 Enhancer 0.4 FANTOM5 Ensembl 8.7 -12.6 -12582 0.3 CLDN25 LOC100288385 piR-58929-017 ZW10 lnc-ZW10-1 TMPRSS5
GH11J114152 Promoter/Enhancer 2.3 UCNEbase FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.2 +383.9 383876 22.1 ZSCAN16 FEZF1 CEBPA MNT IKZF1 BHLHE40 ZEB1 ELF1 ZIC2 ZNF610 ZBTB16 NNMT TTC12 CLDN25 ENSG00000286463 LOC101928875 HSALNG0087292 MN298678-016 RF00017-1033
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLDN25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLDN25

Genomic Locations for CLDN25 Gene

Latest Assembly
chr11:113,779,747-113,780,500
(GRCh38/hg38)
Size:
754 bases
Orientation:
Plus strand

Previous Assembly
chr11:113,650,518-113,651,207
(GRCh37/hg19 by Entrez Gene)
Size:
690 bases
Orientation:
Plus strand

chr11:113,650,469-113,651,222
(GRCh37/hg19 by Ensembl)
Size:
754 bases
Orientation:
Plus strand

Genomic View for CLDN25 Gene

Genes around CLDN25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN25 Gene

Proteins for CLDN25 Gene

  • Protein details for CLDN25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JDP6-CLD25_HUMAN
    Recommended name:
    Putative claudin-25
    Protein Accession:
    C9JDP6

    Protein attributes for CLDN25 Gene

    Size:
    229 amino acids
    Molecular mass:
    25394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN25 Gene

Post-translational modifications for CLDN25 Gene

No Post-translational modifications

Other Protein References for CLDN25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN25 Gene

Domains & Families for CLDN25 Gene

Gene Families for CLDN25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLDN25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLDN25 Gene

GenScript: Design optimal peptide antigens:
  • Putative claudin-25 (CLD25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

C9JDP6

UniProtKB/Swiss-Prot:

CLD25_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN25: view

Function for CLDN25 Gene

Molecular function for CLDN25 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Phenotypes From GWAS Catalog for CLDN25 Gene

Gene Ontology (GO) - Molecular Function for CLDN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with CLDN25: view

miRNA for CLDN25 Gene

miRTarBase miRNAs that target CLDN25

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN25

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLDN25 Gene

Localization for CLDN25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN25 Gene

Cell junction, tight junction. Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN25 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CLDN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0005923 bicellular tight junction IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN25 Gene

Pathways & Interactions for CLDN25 Gene

genes like me logo Genes that share pathways with CLDN25: view

Interacting Proteins for CLDN25 Gene

Gene Ontology (GO) - Biological Process for CLDN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0070830 bicellular tight junction assembly IBA 21873635
genes like me logo Genes that share ontologies with CLDN25: view

No data available for SIGNOR curated interactions for CLDN25 Gene

Drugs & Compounds for CLDN25 Gene

No Compound Related Data Available

Transcripts for CLDN25 Gene

mRNA/cDNA for CLDN25 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN25

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN25 Gene

No ASD Table

Relevant External Links for CLDN25 Gene

GeneLoc Exon Structure for
CLDN25

Expression for CLDN25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLDN25 Gene

mRNA differential expression in normal tissues according to GTEx for CLDN25 Gene

This gene is overexpressed in Pituitary (x22.4), Muscle - Skeletal (x8.8), Testis (x5.4), Skin - Sun Exposed (Lower leg) (x5.0), and Liver (x4.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLDN25

SOURCE GeneReport for Unigene cluster for CLDN25 Gene:

Hs.705360
genes like me logo Genes that share expression patterns with CLDN25: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN25 Gene

Orthologs for CLDN25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN25 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CLDN25 30 31
  • 99.42 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CLDN25 30 31
  • 86.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CLDN25 30 31
  • 85.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100360390 30
  • 80.79 (n)
Oppossum
(Monodelphis domestica)
Mammalia CLDN25 31
  • 59 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cldn13 31
  • 27 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves CLDN25 30 31
  • 59.1 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CLDN25 31
  • 43 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CLDN22 31
  • 35 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10090 31
  • 25 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
Species where no ortholog for CLDN25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CLDN25 Gene

ENSEMBL:
Gene Tree for CLDN25 (if available)
TreeFam:
Gene Tree for CLDN25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLDN25: view image

Paralogs for CLDN25 Gene

(13) SIMAP similar genes for CLDN25 Gene using alignment to 1 proteins:

  • CLD25_HUMAN
genes like me logo Genes that share paralogs with CLDN25: view

Variants for CLDN25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLDN25 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs35111413 - p.His219Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CLDN25 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for CLDN25 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDN25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDN25

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CLDN25 Gene

Disorders for CLDN25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLDN25 Gene - From: COP

Disorder Aliases PubMed IDs
craniofacial-deafness-hand syndrome
  • cdhs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CLDN25

genes like me logo Genes that share disorders with CLDN25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN25 Gene

Publications for CLDN25 Gene

  1. Tight junction proteins at the blood-brain barrier: far more than claudin-5. (PMID: 30734065) Berndt P … Haseloff RF (Cellular and molecular life sciences : CMLS 2019) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The claudins. (PMID: 19706201) Lal-Nag M … Morin PJ (Genome biology 2009) 3
  4. Structure and function of claudins. (PMID: 18036336) Krause G … Blasig IE (Biochimica et biophysica acta 2008) 3
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

Products for CLDN25 Gene

Sources for CLDN25 Gene