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This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]
CLDN25 (Claudin 25) is a Protein Coding gene. Diseases associated with CLDN25 include Craniofacial-Deafness-Hand Syndrome. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Pathogenic Escherichia coli infection. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is CLDN22.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005198 | structural molecule activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA,IBA | 21873635 |
GO:0005923 | bicellular tight junction | IEA,IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030054 | cell junction | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell adhesion molecules (CAMs) | ||
2 | Toll-like Receptor Signaling Pathway |
.34
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3 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling | ||
4 | Pathogenic Escherichia coli infection | ||
5 | Tight junction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IBA | 21873635 |
GO:0070830 | bicellular tight junction assembly | IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CLDN25 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CLDN25 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CLDN25 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC100360390 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CLDN25 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cldn13 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | CLDN25 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CLDN25 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | CLDN22 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10090 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35111413 | - | p.His219Tyr |
Disorder | Aliases | PubMed IDs |
---|---|---|
craniofacial-deafness-hand syndrome |
|
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