External Ids for CLDN25 Gene
Previous GeneCards Identifiers for CLDN25 Gene
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]
GeneCards Summary for CLDN25 Gene
CLDN25 (Claudin 25) is a Protein Coding gene. Diseases associated with CLDN25 include Craniofacial-Deafness-Hand Syndrome. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Pathogenic Escherichia coli infection. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is CLDN22.
UniProtKB/Swiss-Prot Summary for CLDN25 Gene
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.